Management of Hypertension : Current Practice and the Application of Landmark Trials

This book is a valuable tool to assist both cardiovascular physicians and scientists learning the intricacies of hypertension research and its milestone studies. All major hypertension trials have been reviewed in this book in chronological order with extensive discussion of the study population, study design, and outcomes and with a special focus on what knowledge they offered, their strengths and weaknesses, statistical errors, impact on international guidelines and unmet needs. Importantly, the book also offers physicians and young scientists with basic knowledge regarding medical biostatistics. It is of critical importance for a scientist involved in the field to understand deeply the process of analyzing medical data. Moreover, the accurate interpretation of the results is central for applying evidence-based medicine in everyday clinical practice. __Management of Hypertension:__ __Current Practice and the Application of Landmark Trials__is a critical tool to assist in the education of physicians and researchers in the field, providing a separate section on pioneer researchers in hypertension and urging readers to become bright exemplars for scientists wishing to pursue a career in academic medicine and hypertension research. Front Matter ....Pages i-xxiii Front Matter ....Pages 1-1 The Importance of Applying Evidence-Based Medicine in Clinical Practice (Thomas Karagiannis)....Pages 3-17 Medical Biostatistics: Basic Concepts (Konstantinos I. Bougioukas, Anna-Bettina Haidich)....Pages 19-53 Front Matter ....Pages 55-55 Arterial Hypertension and Cardiovascular Risk (Renata Cifkova)....Pages 57-74 The VA Co-operative Studies; The First RCTs in Cardiovascular Disease – A Tribute to Edward D. Freis (Vasilios Papademetriou, Michael Doumas, Costas Tsioufis, Kyriakos Dimitriadis, Charles Faselis)....Pages 75-88 The Role of Dietary Modifications in Controlling Blood Pressure (K. Dimitriadis, C. Filippou, C. Tsioufis)....Pages 89-100 Hypertension Management in the Elderly (Samar A. Nasser, Keith C. Ferdinand)....Pages 101-113 Management of Hypertension in Diabetes Mellitus (Michael Doumas, George L. Bakris)....Pages 115-133 Chronic Kidney Disease and Hypertension (Pedro A. Jose, Van Anthony M. Villar)....Pages 135-143 Hypertension Management in African Americans: The AASK and Other Landmark Trial Application (Ping Li, Annise K. Chung, Samir S. Patel, Vasilios Papademetriou)....Pages 145-154 Comparison Therapies in the Treatment of Hypertension. The ASCOT and ACCOMPLISH Trial (Nikolaos Magkas, Athanasia Kapota, Costas Tsioufis)....Pages 155-182 Outcomes of Different Antihypertensive Regimens (Takeshi Fujiwara, Kazuomi Kario)....Pages 183-214 Advantages and Disadvantages in Clinical Trials (William J. Kostis, Jeanne M. Dobrzynski, John B. Kostis)....Pages 215-238 Arterial Hypertension: What Is the Optimal Goal of Treatment? (Emmanuel A. Andreadis, Charalampia V. Geladari)....Pages 239-252 Front Matter ....Pages 253-253 Methods of Blood Pressure Assessment Used in Milestone Hypertension Trials (Yi Chen, Lei Lei, Ji-Guang Wang)....Pages 255-267 Front Matter ....Pages 269-269 The Life and the Major Scientific Contributions of Irvine Page (Emmanuel A. Andreadis, Charalampia V. Geladari)....Pages 271-273 Neurogenic Mechanisms in Pre-hypertension and Pharmacologic Approaches to the Prevention and Treatment of Hypertension: Highlights of Professor Stevo Julius’ Scientific Contributions (Brent M. Egan)....Pages 275-289 Front Matter ....Pages 291-291 New Frontiers in Cardiovascular Research: Microfluidic Modeling of Cardiovascular Diseases and Applications for Hypertension Research (Iason T. Papademetriou)....Pages 293-302 "This book is a valuable tool to assist both cardiovascular physicians and scientists learning the intricacies of hypertension research and its milestone studies. All major hypertension trials have been reviewed in this book in chronological order with extensive discussion of the study population, study design, and outcomes and with a special focus on what knowledge they offered, their strengths and weaknesses, statistical errors, impact on international guidelines and unmet needs. Importantly, the book also offers physicians and young scientists with basic knowledge regarding medical biostatistics. It is of critical importance for a scientist involved in the field to understand deeply the process of analysing medical data. Moreover, the accurate interpretation of the results is central for applying evidence-based medicine in everyday clinical practice. Management of Hypertension: Current Practice and the Application of Landmark Trials is a critical tool to assist in the education of physicians and researchers in the field, providing a separate section on pioneer researchers in hypertension and urging readers to become bright exemplars for scientists wishing to pursue a career in academic medicine and hypertension research." -- Prové de l'editor This book is a valuable tool to assist both cardiovascular physicians and scientists learning the intricacies of hypertension research and its milestone studies. All major hypertension trials have been reviewed in this book in chronological order with extensive discussion of the study population, study design, and outcomes and with a special focus on what knowledge they offered, their strengths and weaknesses, statistical errors, impact on international guidelines and unmet needs. Importantly, the book also offers physicians and young scientists with basic knowledge regarding medical biostatistics. It is of critical importance for a scientist involved in the field to understand deeply the process of analyzing medical data. Moreover, the accurate interpretation of the results is central for applying evidence-based medicine in everyday clinical practice. Management of Hypertension: Current Practice and the Application of Landmark Trials is a critical tool to assist in the education of physicians and researchers in the field, providing a separate section on pioneer researchers in hypertension and urging readers to become bright exemplars for scientists wishing to pursue a career in academic medicine and hypertension research.