Mammary Tumorigenesis And Malignant Progression: Advances In Cellular And Molecular Biology Of Breast Cancer (cancer Treatment And Research)

The current volume represents the fourth over a period of five years in our series on Advances in the Cellular and Molecular Biology of Breast Cancer. The first three volumes were entitled Breast Cancer: Cellular and Molecular Biology, Regulatory Mechanisms in Breast Cancer, and Genes, Oncogenes, and Hormones, respectively. Throughout this series, we have tried to take a broad look at cutting-edge topics in basic science research into breast cancer. This attempt has resulted in a wide range of subject material, including rodent and human model systems, oncogenes, suppressor genes, growth factors, hormones, tumor-host interactions, and determinants of metastases. Since our last volume, research in breast cancer has continued to proceed at an explosive rate. We hope the current volume will provide the reader with some of the excitement felt by the editors and authors as we begin to understand this all-too-common disease. The first section of this book is devoted to the basic processes of proli­ feration, differentiation, and malignant progression of breast cancer. T.l. Anderson and W.R. Miller lead off with a detailed description of controls on proliferation in the normal human breast and in breast cancer. This chapter strongly emphasizes pathological aspects. The second chapter, by M.R. Stampfer and P. Yaswen, presents a corresponding viewpoint through a presentation of experiments with human mammary epithelial cells in culture. The second section of the book emphasizes the genetic basis for breast cancer onset and malignant progression. Chapter 3, by M.-C. King and S. Front Matter....Pages i-xiv Front Matter....Pages 1-1 Morphological and biological observations relating to the development and progression of breast cancer....Pages 3-27 Growth, differentiation, and transformation of human mammary epithelial cells in culture....Pages 29-48 Front Matter....Pages 49-49 Genetic analysis of breast and ovarian cancer in families....Pages 51-62 The p53 tumor-suppressor gene in human breast cancer....Pages 63-77 Tumor-suppressor genes in breast cancer progression....Pages 79-96 Estrogen receptor variants in breast cancer....Pages 97-109 Hormone ‘resistance’ in breast cancer: The role of normal and mutant steroid receptors....Pages 111-127 Front Matter....Pages 129-129 The epidermal growth factor family in the mammary gland and other target organs for ovarian steroids....Pages 131-160 Molecular and clinical aspects of the Neu/ErbB-2 receptor tyrosine kinase....Pages 161-191 MDGF1: A multifunctional growth factor in human milk and human breast cancer....Pages 193-208 The role of polyamines in the hormonal control of breast cancer cell proliferation....Pages 209-225 Front Matter....Pages 227-227 Modulations of the epithelial phenotype during embryogenesis and cancer progression....Pages 229-249 Cell-cell adhesion in invasion and metastasis of carcinomas....Pages 251-266 Enhancement of tumor growth by basement membrane: Modulation of growth and angiogenesis by laminin-derived synthetic peptides....Pages 267-275 Fetal-like fibroblasts: Their production of migration-stimulating factor and role in tumor progression....Pages 277-298 Urokinase plasminogen activator (uPA) and its type 1 inhibitor (PAI-1): Regulators of proteolysis during cancer invasion and prognostic parameters in Breast cancer....Pages 299-309 Front Matter....Pages 311-311 Molecular mechanisms of chemical carcinogenesis in rodent models....Pages 313-329 Fgf-3, an oncogene in murine breast cancer....Pages 331-343 Back Matter....Pages 345-361

The current volume represents the fourth over a period of five years in the series on advances in the cellular and molecular biology of breast cancer. Throughout this series, a broad view has been taken at what are cutting edge topics in the basic research into breast cancer. Since the last volume, research in breast cancer has continued to proceed at an explosive rate, and the current volume will provide the reader with some of the excitement felt by the editors and authors.
The first section is devoted to the basic process of proliferation, differentiation, and malignant progression of breast cancer. The second section emphasizes the genetic basis for breast cancer onset and malignant progression. The third section deals with growth factors, receptors, and polyamines in proliferation mechanisms. The fourth section is devoted to aspects of metastases and tumor-host interactions. The final section presents recent studies on rodent models of breast cancer.

Genetic basis for cancer onset & progression/growth factors, receptors & polyamines/cancer cell adhesion & migration/etc.