Male Sterility And Motility Disorders: Etiological Factors And Treatment (serono Symposia Usa)

This conference, dedicated to the etiology and treatment of motility disor­ ders in spermatozoa and male sterility, attracted some of the finest investiga­ tors in the field. Standards were immensely high throughout, and discussions were meaningful and detailed. Analyses on disorders in sperm motility de­ mand a broad-based approach, involving cytologists, geneticists, andrologists, and embryologists, because the topic has many clinical and scientific over­ tones. Human spermatozoa are at the mercy of so many factors as they form and mature in the testis and epididymis. Their survival and fundamental char­ acteristics are essential for fertilization, and the male genome imposes its influence on the embryo as it becomes active in male pronuclei very soon after sperm entry into the oocyte. All of these fundamental aspects of sperm biology demanded a broad breadth of topics in the symposium. The opening session quickly got down to fundamentals with contributions from J.-L. Gatti, J.G. Alvarez, C. Gagnon, and H. Breitbart. They discussed the mechanism and regulation of motility, the metabolic strategy of human spermatozoa, the effects of exogenous fac­ tors such as antibodies, infections, and toxins, and finally the role of intracel­ lular calcium on sperm motility. To these topics, the postcoffee session on the first morning described the genetics of motility disorders and the etiology and management of necrozoospermia. The excellent presentation provided the background detail of the symposium and opened the way for the discus­ sion of various clinical aspects of the topic. Front Matter....Pages i-xx Front Matter....Pages 1-1 Motility Update....Pages 3-24 Metabolic Strategy in Human Spermatozoa: Its Impact on Sperm Motility....Pages 25-36 Extrinsic Factors Affecting Sperm Motility: Immunological and Infectious Factors and Reactive Oxygen Species....Pages 37-44 Intracellular Calcium and Sperm Motility....Pages 45-53 Genetic Aspects of Sperm Motility Disorders....Pages 54-64 Necrospermia: Etiology and Management....Pages 65-78 Front Matter....Pages 79-79 In Vivo Therapies for Asthenozoospermia....Pages 81-94 In Vitro Therapy for Sperm Motility: Specific and Nonspecific Treatments....Pages 95-115 Front Matter....Pages 117-117 Injection Procedures of Immotile Sperm: Selection, Tail Breakage, and Viscous Solutions....Pages 119-127 Fertilizing Capability of Frozen-Thawed Immotile Sperm....Pages 128-134 Clinical Aspects of ICSI with Immotile Sperm....Pages 135-140 Intracytoplasmic Sperm Injection in Difficult Cases: The Egyptian Experience....Pages 141-147 Difficult Cases in ICSI (Male Factors)....Pages 148-155 ICSI in Difficult Cases: Total Absence of Both Motile and Normal Spermatozoa....Pages 156-161 Difficult ICSI Cases: An Israeli Survey....Pages 162-170 Front Matter....Pages 171-171 Growth Factors in Testis Development and Function....Pages 173-188 Microinsemination Using Spermatogenic Cells in Mammals....Pages 189-202 Cell Loss During Spermatogenesis: Apoptosis or Necrosis?....Pages 203-214 Regulation of Apoptosis in the Testis....Pages 215-224 Front Matter....Pages 225-225 Thermic and Metabolic Microsensors for Testicular Sperm Extraction (TESE) Before ICSI....Pages 227-238 Front Matter....Pages 225-225 ICSI with Epididymal and Testicular Sperm Retrieval....Pages 239-242 Pathophysiologic Changes after Testicular Sperm Extraction: Patterns and Avoidance of Testicular Injury....Pages 243-252 Cytological Evaluation of Germinal Populations as Part of a Testicular Sperm Retrieval Strategy....Pages 253-258 Front Matter....Pages 259-259 Genetic Aspects of Male Sterility....Pages 261-274 Conceptus Quality from ICSI with Testicular Sperm....Pages 275-281 Genetic Problems and Congenital Malformations in 1987 ICSI Children....Pages 282-297 Ethical Dilemmas in Assisted Reproduction....Pages 298-305 Back Matter....Pages 307-320 This volume is the proceedings of the International Symposium on Male Sterility for Motility Disorders, held in Paris, January 30-31, 1998. The internationally recognized faculty present the latest research on etiologic factors and treatment of male sterility for motility disorders, including the etiology of immobile sperm; therapeutic possibilities for immotile sperm; ICSI option; testicular sperm, physiological and pathological aspects and retrieval; and conceptus quality in ICSI and ethical problems with ART