Male Fertility and Its Regulation (Advances in Reproductive Health Care, 5)

Uncontrolled population growth, a significant problem for many countries, depresses real living standards in all developing areas. As a corollary, un­ controlled population growth also stresses the ability to deliver adequate reproductive health care on both national and individual levels. To focus on this and related problems an International Congress to examine many aspects of male and female Reproductive Health Center Care was held on 10-15 October 1982 in Maui, Hawaii, USA. This volume is a result of the proceedings from the 'Symposium on Male Fertility and its Regulation' which was a part of the Reproductive Health Care Congress. The organizers of this symposium recognized the need to focus male reproductive understanding on contraceptive development. The ultimate objective was and still is to produce a variety of safe and effective male contraceptives similar to that accomplished in the female. Speakers were invited to review the state of the art in several areas related to male contra­ ception, reproductive toxicity and reproductive biology. The abstracts of these sessions were published as a special issue of Archives of Andrology (Vol. 9, No.1, August, 1982). Subsequently, this volume was assembled from key papers presented at the Symposium. Additionally, invited man­ uscripts from leaders in specific areas were solicited to provide additional range to the topics covered. Front Matter....Pages i-xiv Front Matter....Pages 1-1 3-Indazole-carboxylic acids as male antifertility agents....Pages 3-11 Chemotherapeutic agents and male reproduction....Pages 13-24 Effects of 5-thio-D-glucose on male fertility....Pages 25-36 Front Matter....Pages 37-37 Therapeutic drug effects on male reproductive function....Pages 39-48 Reversible male infertility induced by sulphasalazine....Pages 49-54 Effects of illicit drugs on male reproduction....Pages 55-76 Effects of abused substances on male reproductive development....Pages 77-89 Front Matter....Pages 91-91 Gossypol chemistry and plant distribution....Pages 93-110 Toxicological effects of gossypol....Pages 111-133 Biochemical and nutritional considerations of gossypol intake....Pages 135-154 Gossypol contraception and mechanism of action....Pages 155-174 Gossypol inhibition of boar spermatozoal enzymes....Pages 175-184 Gossypol modulation of testosterone secretion and metabolism....Pages 185-191 Gossypol inhibition of LDH-X....Pages 193-199 Front Matter....Pages 201-201 Environmental chemical effects on testicular function....Pages 203-223 Consequences to the progeny of paternal drug exposure....Pages 225-243 Animal tests employed to assess the effects of drugs and chemicals on reproduction....Pages 245-267 Effects of phenoxy acid herbicides and TCDD on male reproduction....Pages 269-286 Human spermatogenesis and fertility following exposure to dibromochloropropane (DBCP)....Pages 287-300 Front Matter....Pages 301-301 LHRH and its analogues: potential for male contraception and for therapy of androgen-dependent syndromes....Pages 303-318 Front Matter....Pages 301-301 Direct regulation of Leydig cell functions by neuropeptides....Pages 319-330 Non-steroidal inhibitors of androgen transport and metabolism....Pages 331-342 Danazol plus testosterone enanthate in male langur monkey....Pages 343-349 Inhibin and male contraception....Pages 351-368 Front Matter....Pages 369-369 The blood-epididymis barrier....Pages 371-382 The tenacity of the blood-testis and blood-epididymal barriers....Pages 383-393 Front Matter....Pages 395-395 Sperm maturation and transport....Pages 397-409 Ionic mechanisms of sperm motility initiation....Pages 411-416 Reproductive effects of sperm surface antibodies....Pages 417-436 Sperm calcium homeostasis during maturation....Pages 437-449 The zona-free hamster egg sperm penetration assay....Pages 451-465 Back Matter....Pages 467-479 Uncontrolled population growth, a significant problem for many countries, depresses real living standards in all developing areas. As a corollary, un controlled population growth also stresses the ability to deliver adequate reproductive health care on both national and individual levels. To focus on this and related problems an International Congress to examine many aspects of male and female Reproductive Health Center Care was held on 10-15 October 1982 in Maui, Hawaii, USA. This volume is a result of the proceedings from the 'Symposium on Male Fertility and its Regulation' which was a part of the Reproductive Health Care Congress. The organizers of this symposium recognized the need to focus male reproductive understanding on contraceptive development. The ultimate objective was and still is to produce a variety of safe and effective male contraceptives similar to that accomplished in the female. Speakers were invited to review the state of the art in several areas related to male contra ception, reproductive toxicity and reproductive biology. The abstracts of these sessions were published as a special issue of Archives of Andrology (Vol. 9, No. 1, August, 1982). Subsequently, this volume was assembled from key papers presented at the Symposium. Additionally, invited man uscripts from leaders in specific areas were solicited to provide additional range to the topics covered