Malassezia and the Skin : Science and Clinical Practice

It has been known for many years that the Malassezia yeasts are associated with a n- ber of different human diseases ranging from pityriasis versicolor to seborrhoeic d- matitis. However the evolving history of their taxonomy and pathogenicity, and the management of the diseases that they cause has been a long, and often diffcult, jou- ney. Their fastidious growth requirements defed the initial attempts to culture these organisms on laboratory media and their true identifcation and the relationship between different species only became apparent with the application of modern molecular techniques. Likewise although recognised in the 19th century as potential causes of human infection, piecing together the complex and, in certain cases, still uncertain relationships to different human diseases has taken many years. Recognised initially as causes of infection of the skin, they are now known to be superfcial c- mensals as well as potential causes of infections in domestic animals and more serious human conditions such as fungemia. They have also been implicated in the pathog- esis of allergic and other infammatory diseases. Given this complex, yet fascinating, history it seems appropriate to bring together current thought on these yeasts, their structure and function and their association with both human and animal disease states. This book provides such a view of the genus Malassezia and the diseases caused by its members. Front Matter....Pages i-xi Introduction: Malassezia Yeasts from a Historical Perspective....Pages 1-16 Biodiversity, Phylogeny and Ultrastructure....Pages 17-63 Epidemiology of Malassezia -Related Skin Diseases....Pages 65-119 Physiology and Biochemistry....Pages 121-137 Malassezia Species and Immunity: Host–Pathogen Interactions....Pages 139-173 Pityriasis Versicolor and Other Malassezia Skin Diseases....Pages 175-199 Malassezia Yeasts in Seborrheic and Atopic Eczemas....Pages 201-228 Malassezia Fungemia, Antifungal Susceptibility Testing and Epidemiology of Nosocomial Infections....Pages 229-251 Genomics and Pathophysiology: Dandruff as a Paradigm....Pages 253-269 Malassezia Yeasts in Animal Disease....Pages 271-299 Malassezia Database....Pages 301-311 Back Matter....Pages 313-319 From the reviews: “In this book, the authors, all experts in Malassezia research, cover the history of the fungal species, associated skin conditions, epidemiology, genomic data and current treatment options. ... the book is extremely well-written, with a consistent format and inclusion of clear and informative figures and tables. ... This book would be an ideal purchase for researchers, clinicians ... with a specialist interest in Malassezia, but also, as the first book to comprehensively review current scientific and clinical Malassezia knowledge, would be a worthwhile institutional purchase.” (Donna MacCallum, Microbiology Today, 2010) This book, written by a group of acknowledged experts, is the first comprehensive overview on the very unusual yeasts of the genus Malassezia. All relevant aspects of the genus and its 13 species are covered in detail within 11 chapters. The first chapter reviews the long and controversial history of the genus, while the second describes all mycological characteristics of the different species, including media and techniques adapted to their isolation, description, and maintenance. Subsequent chapters methodically address issues such as the effect of Malassezia yeasts on human and animal healt This book covers all necessary aspects on the global epidemiology of Malassezia species and their effect on various diseases. Valuable treatment advice is given in order to improve the treatment outcome of affected patients.