Malaria: Drugs, Disease and Post-genomic Biology (Current Topics in Microbiology and Immunology Book 295)

This volume brings some of the worlds best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two. The opening chapters discuss antimalarials and resistance to them in Africa and Asia. Then there are reviews of the different clinical manifestations of malaria, ranging from uncomplicated infections to severe disease and its complications. This section is followed by detailed reviews of what the new ‘omics’ offer to investigators of Plasmodium biology and is completed by descriptions of advances in understanding the biology of Plasmodium in the mosquito. If this volume attracts new students and provokes existing investigators to explore new directions, then it will have achieved much of what it has set out to do. Quinolines And Artemisinin:chemistry, Biology And History / P.g. Bray, S.a. Ward, And P.m. O'neill -- Antimalarial Multi-drug Resistance In Asia: Mechanisms And Assessment / A.-c. Uhlemann And S. Krishna -- Antimalarial Drug Resistance In Africa: Strategies For Monitoring And Deterrence / C.v. Polwe -- Uncomplicated Malaria / M.p. Grobusch And P.g. Kremsner -- Metabolic Complications Of Severe Malaria / T. Planche, A. Dzeing, E. Ngou-milama, M. Kombila, And P.w. Stacpoole -- The Clinical And Pathophysiological Features Of Malarial Anaemia / D.j. Roberts, C. Casals-pascual, And D.j. Weatherall -- Malaria In The Pregnant Woman / P.e. Duffy And M. Fried -- Host Receptors In Malaria Merozoite Invasion / S.s. Oh And A.h. Chishti -- A Post-genomic View Of The Mitochondrion In Malaria Parasites/ A.b Vaidya And M.w. Mather -- The Plastid Of Plasmodium Spp.: A Target For Inhibitors / S. Sato And R.j.m. Wilson -- Hemoglobin Degradation / D.e. Goldberg -- Bioavailable Iron And Heme Metabolism In Plasmodium Falciparum / P.f. Scholl, A.k. Tripathi, And D.j. Sullivan -- Plasmodium Permeomics: Membrane Transport Proteins In The Malaria Parasite / K. Kirk, R.e. Martin, S. Broer, S.m. Howitt, And K.j. Saliba -- Plasmodium Ookinete Invasion Of The Mosquito Midgut / J.m. Vinetz -- Molecular Genetics Of Mosquito Resistance To Malaria Parasites/ K.d. Vernick, . F. Oduol, B.p. Lazzaro, J. Glazebrook, J. Xu, M. Riehle, And J. Li -- Functional Proteome And Expression Analysis Of Sporozoites And Hepatic Stages Of Malaria Development / P.l. Blair And D.j. Carucci. D.j. Sullivan And S. Krishna (eds.). Includes Bibliographical References And Index. Molecular Evolution Of Adenoviruses / M. Benkö, B. Harrach -- Novel Partner Proteins Of Adenovirus Penton / J. Chroboczek ... [et Al.] -- Structural Studies On Adenoviruses / C. San Martín, R. M. Burnett -- The Multifunctional Role Of E1a In The Transcriptional Regulation Of Creb/cbp-dependent Target Genes / D. Brockmann, H. Esche -- Adenovirus Dna Replication / H. Liu, J. H. Naismith, R. T. Hay -- Regulation Of Adenovirus Packaging / P. Ostapchuk, P. Hearing -- Adenovirus Dna Replication : Protein Priming, Jumping Back And The Role Of The Dna Binding Protein Dbp / R. N. De Jong, P. C. Van Der Vliet, A. B. Brenkman -- The Structure And Function Of The Adenovirus Major Late Promoter / C. S. H. Young -- Remodelling Of The Host Cell Rna Splicing Machinery During An Adenovirus Infection / G. Akusjärvi, J. Stévenin -- Regulation Of Mrna Production By The Adenoviral E1b 55--kda And E4 Orf6 Proteins / S. J. Flint, R. A. Gonzalez -- Adenovirus Interaction With Its Cellular Receptor Car / J. Howitt, C. W. Anderson, P. Freimuth -- Transactivation Of Human Cdc2 Promoter By Adenovirus E1a / R. Padmanabhan, A. Tanimoto, Y. Sasaguri -- Nuclear Perturbations Following Adenovirus Infection / W. C. Russell, D. A. Matthews -- The Abortive Infection Of Syrian Hamster Cells With Human Adenovirus Type 12 / M. Hösel ... [et Al.] W. Döerfler, P. Böhm (eds.). Includes Bibliographical References And Index. Quinolines and Artemisinin: Chemistry, Biology and History....Pages 3-38 Antimalarial Multi-Drug Resistance in Asia: Mechanisms and Assessment....Pages 39-53 Antimalarial Drug Resistance in Africa: Strategies for Monitoring and Deterrence....Pages 55-79 Uncomplicated Malaria....Pages 81-104 Metabolic Complications of Severe Malaria....Pages 105-136 The Clinical and Pathophysiological Features of Malarial Anaemia....Pages 137-168 Malaria in the Pregnant Woman....Pages 169-200 Host Receptors in Malaria Merozoite Invasion....Pages 203-232 A Post-genomic View of the Mitochondrion in Malaria Parasites....Pages 233-250 The Plastid of Plasmodium spp.: A Target for Inhibitors....Pages 251-273 Hemoglobin Degradation....Pages 275-291 Bioavailable Iron and Heme Metabolism in Plasmodium falciparum ....Pages 293-324 Plasmodium Permeomics: Membrane Transport Proteins in the Malaria Parasite....Pages 325-356 Plasmodium Ookinete Invasion of the Mosquito Midgut....Pages 357-382 Molecular Genetics of Mosquito Resistance to Malaria Parasites....Pages 383-415 Functional Proteome and Expression Analysis of Sporozoites and Hepatic Stages of Malaria Development....Pages 417-438 ".....Brings together some of the world's best investigators to describe recent advances both in the scientific and clinical aspects of malaria and bridges the two. The opening chapters discuss anti-malarials and resistance to them in Africa and Asia. The next section comprises reviews of the different clinical manifestations of malaria, ranging from uncomplicated infections to severe disease and its complications. This is followed by detailed reviews of what the new "omics" offer to investigators of Plasmodium biology and is completed by descriptions of advances in understanding the biology of Plasmodium in the mosquito." Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two. Although adenoviruses have been isolated from every class of vertebrates including fishes, amphibians and reptiles (RUSSELL and BENKÖ 1999), according to the International Committee on Taxonomy of Viruses-approved official taxonomy (BENKÖ et al. 2000) the family Adenoviridae contains only two genera (Mastadenovirus and Aviadenovirus). After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens.