Malaria: Drugs, Disease and Post-genomic Biology (Current Topics in Microbiology and Immunology (295))

Despite rapid increases in knowledge, malaria continues to kill more than a million people each year and causes symptomatic disease in a further 300 million individuals. This volume brings some of the world's best investigators to describe recent advances in both the scientific and clinical aspects of malaria, and bridges between the two. Quinolines And Artemisinin:chemistry, Biology And History / P.g. Bray, S.a. Ward, And P.m. O'neill -- Antimalarial Multi-drug Resistance In Asia: Mechanisms And Assessment / A.-c. Uhlemann And S. Krishna -- Antimalarial Drug Resistance In Africa: Strategies For Monitoring And Deterrence / C.v. Polwe -- Uncomplicated Malaria / M.p. Grobusch And P.g. Kremsner -- Metabolic Complications Of Severe Malaria / T. Planche, A. Dzeing, E. Ngou-milama, M. Kombila, And P.w. Stacpoole -- The Clinical And Pathophysiological Features Of Malarial Anaemia / D.j. Roberts, C. Casals-pascual, And D.j. Weatherall -- Malaria In The Pregnant Woman / P.e. Duffy And M. Fried -- Host Receptors In Malaria Merozoite Invasion / S.s. Oh And A.h. Chishti -- A Post-genomic View Of The Mitochondrion In Malaria Parasites/ A.b Vaidya And M.w. Mather -- The Plastid Of Plasmodium Spp.: A Target For Inhibitors / S. Sato And R.j.m. Wilson -- Hemoglobin Degradation / D.e. Goldberg -- Bioavailable Iron And Heme Metabolism In Plasmodium Falciparum / P.f. Scholl, A.k. Tripathi, And D.j. Sullivan -- Plasmodium Permeomics: Membrane Transport Proteins In The Malaria Parasite / K. Kirk, R.e. Martin, S. Broer, S.m. Howitt, And K.j. Saliba -- Plasmodium Ookinete Invasion Of The Mosquito Midgut / J.m. Vinetz -- Molecular Genetics Of Mosquito Resistance To Malaria Parasites/ K.d. Vernick, . F. Oduol, B.p. Lazzaro, J. Glazebrook, J. Xu, M. Riehle, And J. Li -- Functional Proteome And Expression Analysis Of Sporozoites And Hepatic Stages Of Malaria Development / P.l. Blair And D.j. Carucci. D.j. Sullivan And S. Krishna (eds.). Includes Bibliographical References And Index. ".....Brings together some of the world's best investigators to describe recent advances both in the scientific and clinical aspects of malaria and bridges the two. The opening chapters discuss anti-malarials and resistance to them in Africa and Asia. The next section comprises reviews of the different clinical manifestations of malaria, ranging from uncomplicated infections to severe disease and its complications. This is followed by detailed reviews of what the new "omics" offer to investigators of Plasmodium biology and is completed by descriptions of advances in understanding the biology of Plasmodium in the mosquito."