Macromolecules and Behavior

In the five years since the publication of the First Edition, a tremendous amount of research has been conducted attempting to relate macromolecules and behavior. New approaches to the overall problem have developed. Several chapters of the First Edition were not continued in this edition; most of those which were included have been revised thoroughly. A number of chapters by other contributors were invited to help round out the volume. New chapters are those by Glassman and Wilson; Squire and Barondes; Ungar; Jankovic; Hyden and Lange; Koenig; Appel; Rosenzweig, Bennett, and Diamond; and Deutsch. This edition should provide a representative view of the important research and theorizing which is occurring in this area. This volume is built around two important topics: Products of DNA Activa tion (Section II) and Macromolecules and Intracellular, Intercellular, and Synaptic Events (Section III). The Introduction (Section I) leads to these topics, and Models of Memory (Section IV) attempts to provide an integration of these topics with brain function. The preparation of this volume was facilitated by grants from the National Research Council (Canada) and by Contract No. Nom 4935(00) with the Physiological Psychology Division of the Office of Naval Research (U .S.A.) Front Matter....Pages i-xi Front Matter....Pages 1-1 Introduction....Pages 3-9 Front Matter....Pages 11-11 Macromolecules—Functional and Biochemical Correlates....Pages 13-38 Brain Function and RNA....Pages 39-46 Macromolecules and Brain Function....Pages 47-59 Inhibitors of Cerebral Protein or RNA Synthesis and Memory....Pages 61-82 Biological Assays for the Molecular Coding of Acquired Information....Pages 83-98 Biological Activity of Antibrain Antibody—An Introduction to Immunoneurology....Pages 99-130 Correlation of the S-100 Brain Protein with Behavior....Pages 131-143 Front Matter....Pages 145-145 Axoplasmic Flow—the Fast Transport System in Mammalian Nerve Fibers....Pages 147-166 A Molecular Basis for Regional Differentiation of the Excitable Membrane....Pages 167-183 Macromolecular Synthesis in Synapses....Pages 185-203 Chemical and Anatomical Plasticity of Brain: Replications and Extensions, 1970....Pages 205-277 Macromolecular Change and the Synapse....Pages 279-303 Autoradiographic Examination of Behaviorally Induced Changes in the Protein and Nucleic Acid Metabolism of the Brain....Pages 305-334 Macromolecular Changes Within Neuron-neuroglia Unit during Behavioral Events....Pages 335-358 Front Matter....Pages 359-359 Molecular Biological Approaches to the Study of Memory....Pages 361-366 Some Dimensions of Remembering: Steps Toward a Neuropsychological Model of Memory....Pages 367-393 Erratum to: Chemical and Anatomical Plasticity of Brain: Replications and Extensions, 1970....Pages 398-399 Back Matter....Pages 395-397 I. Introduction.- 1. Introduction.- II. Products of DNA Activation.- 2. Macromolecules-Functional and Biochemical Correlates.- 3. Brain Function and RNA.- 4. Macromolecules and Brain Function.- 5. Inhibitors of Cerebral Protein or RNA Synthesis and Memory.- 6. Biological Assays for the Molecular Coding of Acquired Information.- 7. Biological Activity of Antibrain Antibody-an Introduction to Immunoneurology.- 8. Correlation of the S-100 Brain Protein with Behavior.- III. Macromolecules and Intracellular, Intercellular, and Synaptic Events.- 9. Axoplasmic Flow-The Fast Transport System in Mammal