Lung Metabolism : Proteolysis and Antioproteolysis Biochemical Pharmacology Handling of Bioactive Substances

Lung Metabolism: Proteolysis and Antiproteolysis Biochemical Pharmacology Handling of Bioactive Substances focuses on studies on the response of the lung relative to the management of bioactive substances. Divided into three sections with 35 chapters, the book focuses first on proteolysis and antiproteolysis in the lung. Concerns include properties and role of antiproteases; role of leucoproteases in the development of emphysema; and the genetic and clinical considerations of alpha1-antitrypsin deficiencies. The second section focuses on biochemical pharmacology of the lung. Concerns include pulmonary drug-metabolizing enzymes; carrier for oxygen and carbon monoxide in the lung; and metabolism of drugs administered by aerosol. The last section looks at the handling of bioactive substances by the lung. Covered areas include the pharmacokinetic function of the lung; biosynthesis and metabolism of prostaglandins in the lung; and importance and nature of the mechanism of inactivation of prostaglandins in the lung. The book is a vital source of information for readers interested in studying the metabolism of the lung. Content: Academic Press Rapid Manuscript Reproduction , Page ii Front Matter , Page iii Copyright , Page iv List of Contributors , Pages ix-xii Preface , Pages xiii-xiv , A.F. Junod, R. de Haller PROPERTIES AND ROLE OF ANTIPROTEASES , Pages 3-24 , N. Heimburger ROLE OF LEUCOPROTEASES IN THE GENESIS OF EMPHYSEMA , Pages 25-41 , P. Kimbel, G. Weinbaum BACTERIAL PROTEOLYTIC ENZYMES , Pages 43-56 , H. Zuber MYCOTIC PROTEOLYTIC ENZYMES , Pages 57-65 , J. Nicolet, Elizabeth S.N. Bannerman, R. de Haller GENETIC CONSIDERATIONS ON ALPHA 1 -ANTITRYPSIN DEFICIENCY , Pages 67-82 , F. Kueppers CLINICAL SPECTRUM OF ALPHA 1 -ANTITRYPSIN DEFICIENCY , Pages 83-100 , J. Lieberman THE ANTIPROTEOLYTIC SYSTEM OF THE UPPER RESPIRATORY TRACT , Pages 101-105 , K. Hochstrasser, R. Reichert, K. Schorn STUDIES OF ALPHA 1 -ANTITRYPSIN IN AMNIOTIC FLUID, MECONIUM AND CORD SERUM OF A HOMOZYGOTE NEWBORN INFANT , Pages 107-122 , D. Kaiser, D. Sidiropoulos, P. Kehrli, O.M. Rennert INFLUENCE OF INTRAVENOUS INJECTION OF D-PENICILLAMINE AND TRASYLOL R ON THE SERUM LEVELS OF ALPHA 1 -ANTITRYPSIN IN HUMAN SUBJECTS , Pages 123-129 , U.H. Cegla PULMONARY DRUG-METABOLIZING ENZYMES , Pages 133-158 , H. Remmer A SPECIFIC CARRIER FOR OXYGEN AND CARBON MONOXIDE IN THE LUNG , Pages 159-184 , B. Burns, G.H. Gurtner, H. Peavy, Y.N. Cha PULMONARY METABOLISM OF INHALED SUBSTANCES AND POSSIBLE RELATIONSHIP WITH CARCINOGENICITY AND TOXICITY , Pages 185-200 , G.M. Cohen METABOLISM OF DRUGS ADMINISTERED BY AEROSOL , Pages 201-217 , D.S. Davies MECHANISMS OF DRUG ACCUMULATION IN THE LUNG , Pages 219-231 , A.F. Junod HORMONE RECEPTORS IN THE LUNG , Pages 233-249 , M.E. Conolly, J.K. Greenacre LUNG AND COAGULATION , Pages 251-261 , F. Duckert DRUG-INDUCED PULMONARY CHANGES , Pages 263-273 , D. Heath PARAQUAT POISONING - Possible Therapeutic Approach , Pages 275-277 , D.S. Davies, M.E. Conolly GENERAL DISCUSSION , Pages 279-289 THE PHARMACOKINETIC FUNCTION OF LUNG , Pages 293-299 , Y.S. Bakhle BIOSYNTHESIS AND METABOLISM OF PROSTAGLANDINS IN THE LUNG , Pages 301-313 , E. Änggård CONDITIONS OF RELEASE OF PROSTAGLANDINS FROM THE LUNG , Pages 315-324 , Priscilla J. Piper IMPORTANCE AND NATURE OF THE MECHANISM OF INACTIVATION OF PROSTAGLANDINS IN THE LUNG , Pages 325-335 , Priscilla J. Piper DIPEPTIDYL CARBOXYPEPTIDASE IN LUNG AND BLOOD PLASMA , Pages 337-346 , M. Roth, D. Depierre BRADYKININASE AND CONVERTING ENZYME IN LUNG , Pages 347-363 , Y.S. Bakhle MEASUREMENT OF PROSTAGLANDINS E 1, E 2 AND Fα, HISTAMINE AND SEROTONIN, UPSTREAM AND DOWNSTREAM THE LUNG DURING PULMONARY VASOPRESSOR RESPONSE TO HYPOXIA IN MAN. EFFECTS OF PROSTAGLANDIN SYNTHESIS INHIBITORS , Pages 365-385 , P. Even, F. Dray, F. Ruff, P. Duroux, MC. Santais, H. Sors MECHANISM OF UPTAKE OF BIOGENIC AMINES IN THE PULMONARY CIRCULATION , Pages 387-398 , A.F. Junod METABOLIC ACTIVITIES OF PLASMA MEMBRANE AND CAVEOLAE OF PULMONARY ENDOTHELIAL CELLS, WITH A NOTE ON PULMONARY PROSTAGLANDIN SYNTHETASE , Pages 399-424 , J.W. Ryan, U.S. Ryan SEVERAL PLASMA PROTEINS DEMONSTRATED IN LUNG TISSUE BY IMMUNOELECTRON MICROSCOPY USING THE PEROXIDASE COUPLING TECHNIQUE , Pages 425-433 , J. Bignon CARDIOPULMONARY BYPASS AND CONVERSION OF ANGIOTENSIN I IN MAN , Pages 435-444 , L. Favre, M.B. Vallotton, A.F. Muller CLINICAL ASPECTS OF HYDROLYSIS OF VASOACTIVE PEPTIDES IN THE PULMONARY CIRCULATION , Pages 445-457 , B. Friedli SOME CHANGES IN THE LUNGS ASSOCIATED WITH CARDIOPULMONARY BYPASS , Pages 459-479 , D.J. Parker SERUM COMPLEMENT STUDIES DURING AND FOLLOWING CARDIOPULMONARY BYPASS , Pages 481-487 , D.J. Parker, S. Cook, Margaret Turner-Warwick SERUM COMPLEMENT STUDIES: GENERAL DISCUSSION , Pages 489-491 CONCLUDING REMARKS , Pages 493-494 , A.F. Junod AUTHOR INDEX , Pages 495-496 Subject Index , Pages 497-501