Lung Development

Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ. Front Matter....Pages i-xv Lung Branching Morphogenesis: Role of Growth Factors and Extracellular Matrix....Pages 1-27 Development of Lung Elastic Matrix....Pages 28-45 Differentiation and Maturation of Airway Epithelial Cells: Role of Extracellular Matrix and Growth Factors....Pages 46-76 Gene Expression in Alveolar Development....Pages 77-121 Lung Development and Pulmonary Angiogenesis....Pages 122-151 Development of the Pulmonary Vasculature....Pages 152-195 Nitric Oxide and Endothelin in the Developing Pulmonary Circulation: Physiologic and Clinical Implications....Pages 196-220 Development of Cellular Host Defense Mechanisms....Pages 221-254 Development of Lung Epithelial Ion Transport: Implications for Neonatal Lung Disease....Pages 255-281 Mechanisms of Cell Growth and Tissue Repair....Pages 282-303 Bioactive Peptides and Lung Development....Pages 304-326 Transgenic Models of Lung Development and Disease....Pages 327-346 Nutritional Aspects of Lung Development....Pages 347-363 Pulmonary Hypoplasia: Role of Mechanical Factors in Prenatal Lung Growth....Pages 364-394 Pulmonary Antioxidant Defense Mechanisms....Pages 395-424 Lung Development after Transplantation....Pages 425-439 Back Matter....Pages 441-451