Lung Cancer Metastasis : Novel Biological Mechanisms and Impact on Clinical Practice

Lung cancer is the leading cause of cancer related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic disease, to the systems biology approach for gaining insights into the mechanisms of metastasis. Some of the subjects covered will include: defining basic hallmarks of a metastatic cell, the concept of tumor stem cells, epithelial-mesenchymal transitions, evasion of immune-surveillance, tumor-stromal interactions, angiogenesis, molecular imaging and biomarker discovery. The primary audience for this book are physicians involved in the management of lung cancer in the clinic, clinical investigators and basic scientists focused on lung cancer research, cancer biologists investigating mechanisms of metastasis, pharmaceutical and biotechnology industry professionals with an interest in development of metastasis-targeted diagnostics and therapeutics, and graduate students and postdoctoral fellows in cancer biology programs. Front Matter....Pages i-xiii Lung Cancer: Overview....Pages 1-27 Hallmarks of Metastasis....Pages 29-46 Tumor Stem Cells and Metastasis....Pages 47-63 Epithelial–Mesenchymal Transition as a Mechanism of Metastasis....Pages 65-92 Mechanisms of Tumor Cell Migration and Invasion in Lung Cancer Metastasis....Pages 93-109 Immunologic Mechanisms in Lung Carcinogenesis and Metastasis....Pages 111-134 Angiogenesis and Angiogenic Diversity in Lung Cancer Metastasis....Pages 135-154 Chemokines in Lung Cancer Metastasis....Pages 155-172 Molecular Control of Lymphatic Metastasis in Lung Cancer....Pages 173-191 Carcinoma-Associated Fibroblasts in Lung Cancer....Pages 193-215 The Role of Tumor-Associated Macrophages and Other Innate Immune Cells in Metastatic Progression of Lung Cancer....Pages 217-239 Experimental Animal Models for Studying Lung Cancer....Pages 241-265 Molecular Imaging in Lung Cancer Metastases....Pages 267-287 Biomarker Discovery for Metastatic Disease....Pages 289-315 Current Clinical Management of Metastatic Lung Cancer....Pages 317-350 Site-Directed Therapy for Lung Cancer Metastases....Pages 351-381 Systems Approach for Understanding Metastasis....Pages 383-394 Back Matter....Pages 395-409