Lung Biology in Health & Disease Volume 191 Long-Term Intervention in Chronic Obstructive Pulmonary Disease

Reviewing current strategies and methods to treat and manage patients suffering with ventilatory dysfunction, this reference provides a critical overview of the epidemiology, pathophysiology, diagnosis, and outcomes of COPD-describing techniques to prevent and reduce the development of symptoms, improve patient quality of life, and slow the progression of disease. Front cover 1 INTRODUCTION 12 PREFACE 14 CONTRIBUTORS 18 Contents 22 Chapter 1. Definitions of Chronic Obstructive Pulmonary Disease 30 Chapter 2. COPD: Worldwide Prevalence 44 Chapter 3. Worldwide Mortality from COPD 66 Chapter 4. Risk Factors for the Development of COPD 82 Chapter 5. Risk Factors for the Progression of COPD 100 Chapter 6. Socioeconomic Burden of COPD 130 Chapter 7. Pathology of COPD 148 Chapter 8. Inflammatory Mechanisms 168 Chapter 9. Defective Repair in COPD: The American Hypothesis 194 Chapter 10. Proteinases in COPD 230 Chapter 11. Oxidative Stress and COPD 252 Chapter 12. Pathogenesis of Infections in COPD Patients 300 Chapter 13. Extrapulmonary Effects of COPD 324 Chapter 14. Smoking Cessation 344 Chapter 15. Anticholinergics 382 Chapter 16. Long-Acting Beta-Adrenoreceptor Agonists for the Treatment of COPD 412 Chapter 17. The Role of Glucocorticosteroids in the Management of COPD 436 Chapter 18. Antibiotics in COPD 452 Chapter 19. Long-Term Intervention Studies: a1-Antitrypsin Substitution 474 Chapter 20. Surgery and Transplantation for COPD 492 Chapter 21. New Therapies for COPD 508 INDEX 532 Back cover 550 "Reviewing current strategies and methods to treat and manage patients suffering with ventilatory dysfunction, this reference provides a critical overview of the epidemiology, pathophysiology, diagnosis, and outcomes of COPD - describing techniques to prevent and reduce the development of symptoms, improve patient quality of life, and slow the progression of disease."--Jacket