Lung Biology in Health & Disease Volume 182 Pharmacotherapy in Chronic Obstructive Pulmonary Disease

Placing specialists at the cutting-edge of therapeutic and biotechnological research, this reference reviews the extensive array of pharmaceutical options available for the management of patients with COPD. The book considers disease severity, dosing regimens, administration methods, and monitoring procedures, as well as medication-related side-effects for improved lung function, reduction of disease symptoms, and enhanced quality of life. Contributions from world-renowned authorities reflect recent practices, controversies, and procedures in the control of COPD symptoms and detail the development and efficacy of therapies such as anticholinergics, beta adrenergics, and corticosteroids. Providing evidence of therapeutic benefit in clinical drug development / Steven Kesten and Theodore J. Witek Use of expiratory airflows and lung volumes to assess outcomes in COPD / Gary T. Ferguson Exercise testing / Denis E. O'Donnell and Katherine A. Webb Sleep-related breathing disturbances in COPD / Walter T. McNicholas Airway and alveolar determinants of airflow limitation in COPD / Noe Zamel Gas exchange / Antoni Ferrer, Joan Albert Barberá, and Roberto Rodriguez-Roisin Genetics of COPD / Jian-Quing He, Ikuma Kasuga, and Peter D. Paré Dyspnea / Donald A. Mahler Exacerbations of COPD / Jadwiga A. Wedzicha Health status measurement in COPD / Paul W. Jones Health resource utilization / Mitchell Friedman Anticholinergics / Peter J. Barnes gbs-adrenergic receptor agonist bronchodilators in the treatment of COPD / Stephen I. Rennard Theophylline and phosphodiesterase inhibitors in COPD / Alicia R. ZuWallack and Richard L. ZuWallack Corticosteroids in COPD / Mario Cazzola, Maria Gabriella Matera, and Romain Pauwels Antioxidants and protease inhibitors / Mario Cazzola and Maria Gabriella Matera An integrated approach to the pharmacological therapy of COPD / Bartolome R. Celli. Reviews an array of pharmaceutical options available for the management of patients with COPD. This book considers disease severity, dosing regimens, administration methods, and monitoring procedures, as well as medication-related side-effects for improved lung function, reduction of disease symptoms, and enhanced quality of life. This volume considers the application of clinical assessment to the drug development process. Important topics include genetics and sleep-related breathing disturbances in COPD The primary goal of the clinical development of pharmacological therapeutics is to provide useful agents for clinical practice.