Lung Biology in Health & Disease Volume 177 Therapeutic Targets in Airway Inflammation

This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction, progression, and exacerbation of disease. INTRODUCTION......Page 13 PREFACE......Page 15 CONTRIBUTORS......Page 17 CONTENTS......Page 25 Pathophysiology of Airway Inflammation in Asthma......Page 41 Primary Human Lung Cells in the Evaluation of Airway Inflammation......Page 95 Airway pH Homeostasis in Asthma and Other Inflammatory Lung Diseases......Page 103 Monitoring of Exhaled Breath to Assess Airway Inflammation in Asthma......Page 121 The Modulatory Effects of Carbon Monoxide on the Inflammatory Response......Page 133 Reactive Nitrogen Species and Tyrosine Nitration in Airway Inflammation......Page 141 S-Nitrosothiols in Lung Inflammation......Page 163 Contribution of Nitric Oxide Synthase Isoforms to Allergen-Induced Airway Hyperresponsiveness and Inflammation......Page 183 Molecular Mechanisms of Increased Nitric Oxide in Airway Inflammation......Page 207 Regulation of Nitric Oxide Synthesis by Inducible Nitric Oxide Synthase......Page 221 Novel Strategies for Selective Inhibition of Inducible Nitric Oxide Synthase......Page 239 Leukocyte Recruitment in Allergic Pulmonary Inflammation......Page 263 Neutrophil Emigration in the Lungs......Page 289 Dendritic Cells......Page 321 Roles of Mast Cells in Airway Hyperreactivity, Inflammation and Remodeling, and Immunoregulation in Asthma......Page 339 Mast Cell Exocytosis in Airway Inflammation......Page 367 Mast Cell Proteases......Page 389 Peroxidases and Asthma......Page 413 Chemokines in Allergic Airway Inflammation......Page 437 Role of the Eotaxin Subfamily of Chemokines in Allergic Eosinophilic Inflammation......Page 461 Interleukin-4 and Interleukin-13 in Human and Experimental Asthma......Page 505 Interleukin-5 and Eosinophils as Therapeutic Targets for the Treatment of Asthma......Page 519 Modulating the Interleukin-5 Response in Asthma......Page 535 The Role of Interleukin-9 in Allergic Inflammation of Asthma......Page 559 Epithelial Production of IL-12 p80 During Viral Infection and Asthma Supports an Altered Paradigm for Airway Inflammation......Page 575 Interleukin-16 and Airway Hyperresponsiveness in Asthma......Page 603 Modulation of the Allergic Response......Page 621 Inhibition of Cytokine Signaling......Page 639 Eicosanoids as Mediators and Therapeutic Targets in Airway Inflammation......Page 667 Nitric Oxide, Reactive Nitrogen Species, and Lipid Mediator Generation in the Lung......Page 697 Adenosine Signaling and Lung Inflammation......Page 721 Complement Factor 5 in Asthma......Page 739 Complement Anaphylatoxin Receptors in Asthma......Page 755 Inflammatory and Structural Changes in Airway Remodeling of Asthma......Page 763 The Role of Proteases in Airway Remodeling......Page 789 Airway Smooth Muscle......Page 807 Cellular Trafficking of Beta2-Adrenergic Receptors......Page 821 Genetic Targets in Asthma......Page 837 Application of Pharmacogenetics to the Therapeutics of Asthma......Page 863 DNA-Based Immunotherapy for Asthma......Page 879 Allergen Immunotherapy......Page 907 Peptide-Based Therapy for Asthma......Page 931 Reducing IgE Levels as a Strategy for the Treatment of Asthma......Page 947 Strategies to Reduce Excessive Mucus Secretion in Airway Inflammation......Page 963 INDEX......Page 991