Lung Biology in Health & Disease Volume 170 Disease Markers in Exhaled Breath

With nearly 1700 references, Disease Markers in Exhaled Breath is essential reading for pulmonologists; anesthesiologists; physiologists; chest, pulmonary, thoracic, and cardiovascular physicians and surgeons; asthmologists; and upper-level undergraduate, graduate, and medical school students in these disciplines. It discusses the potential diagnostic value of markers in several disorders including cancer, asthma, transplant rejection, and heart disease. INTRODUCTION......Page 11 PREFACE......Page 13 CONTRIBUTORS......Page 19 CONTENTS......Page 25 Nitric Oxide as a Biological Mediator......Page 35 Physiology of Exhaled Nitric Oxide......Page 61 Molecular and Cellular Sources of Exhaled Nitric Oxide......Page 105 Determinants of Exhaled Nitric Oxide Influence of Ventilation and Pulmonary Blood Flow......Page 123 Heme Oxygenase-1 in Lung Disease......Page 149 Carbon Monoxide A Gaseous Molecule with Anti-Inflammatory Properties......Page 165 Role of Reactive Oxygen and Nitrogen Species in Lung Injury......Page 191 Exhaled Nitric Oxide, Carbon Monoxide, and Breath Condensate......Page 231 Analysis of Volatile Organic Compounds in the Breath......Page 251 Regulation of Nitric Oxide Synthases and Gas-Phase Nitric Oxide by Oxygen......Page 267 Exhaled Markers in Interstitial Lung Disease and Pulmonary Hypertension......Page 279 Exhaled Nitric Oxide in Human Lung Ischemia-Reperfusion......Page 291 Monitoring Distant Organ Reperfusion Injury by Measurement of Volatile Organic Compounds......Page 313 Exhaled Nitric Oxide, Carbon Monoxide, and Breath Condensate in Inflammatory Lung Disease and Response to Medical Treatment......Page 339 Exhaled Gas Disease Markers in Septicemia A Possible Role for Nitric Oxide in Lung Injury......Page 375 Exhaled Breath Markers in Acute Respiratory Distress Syndrome......Page 395 Exhaled Nitric Oxide in Human Lung Transplant Recipients......Page 413 Nitric Oxide in Cystic Fibrosis......Page 435 Exhaled Nitric Oxide in Rheumatic Diseases......Page 453 The Disturbance of Metabolism of Oxides of Nitrogen in Liver Disease Exhaled Nitric Oxide as a Measure of Severity......Page 477 AUTHOR INDEX......Page 495 This reference examines recent revelations in the diagnostic roles of nitric oxide, carbon monoxide, and volatile organic compounds in lung disease -- emphasizing the merits of a noninvasive assessment of airway inflammation and oxidative stress through the analysis of exhaled breath and condensate to monitor disease severity and responsiveness to medication at a molecular level. Discusses the potential diagnostic value of markers in several disorders, including cancer, asthma, transplant rejection, and heart disease Since its discovery as an endothelial-derived relaxant factor (EDRF), nitric oxide (NO) has been demonstrated to play a critical role in numerous physiological processes, as well as in the pathophysiology of many diseases.