Lung Biology in Health & Disease Volume 134 Anticholinergic Agents in the Upper and Lower Airways

This comprehensive collection discusses anticholinergic agents, integrating the treatment of rhinitis, the common cold, and asthma in the upper and lower airways, while updating the latest therapeutic practices. Features assessments of soon-to-be-available medications! Written by expert allergists and pulmonologists as an exploration of the Annotation By addressing both asthma and rhinitis, the collection of ten contributions deals with both the upper and lower airways in an integrated way, especially with regard to cholinergic mechanisms. Although the collection primarily discusses the clinical application of antimuscarinics, chapters are included on the physiological and molecular aspects of anticholinergic therapy in order to provide background for clinical discussion. Among the topics are hyperresponsiveness and the M2 and M3 receptors, the interactions of muscarinic receptors with other substances such as protein kinase C and cytokines, data regarding the combination of beta agonists and antimuscarinics, and the future of tiotropium bromide as a bronchodilator. Annotation c. Book News, Inc., Portland, OR (booknews.com) Introduction......Page 11 Preface......Page 13 Contributors......Page 15 Contents......Page 17 Basics of Muscarinic Physiology......Page 22 Airway Muscarinic Receptors......Page 49 Anticholinergic Agents as Bronchodilators......Page 75 Anticholinergic Drug Therapy in the Management of Acute Severe Asthma......Page 89 Use of Anticholinergics in Perennial Rhinitis......Page 102 Pathogenesis and Treatment of Upper Respiratory Infections......Page 115 Anticholinergics in Combination Bronchodilator Therapy in COPD......Page 132 Tiotropium (Ba 679) Pharmacology and Early Clinical Observations......Page 150 Historical Aspects of Medicinal Uses of Antimuscarinics......Page 166 Interaction of Virus with the Muscarinic Receptor......Page 181 AUTHOR INDEX......Page 198 SUBJECT INDEX......Page 218 By addressing both asthma and rhinitis, the collection of ten contributions deals with both the upper and lower airways in an integrated way, especially with regard to cholinergic mechanisms. Although the collection primarily discusses the clinical application of antimuscarinics, chapters are included on the physiological and molecular aspects of anticholinergic therapy in order to provide background for clinical discussion. Among the topics are hyperresponsiveness and the M2 and M3 receptors, the interactions of muscarinic receptors with other substances such as protein kinase C and cytokines, data regarding the combination of beta agonists and antimuscarinics, and the future of tiotropium bromide as a bronchodilator. Annotation copyrighted by Book News, Inc., Portland, OR Basic Science -- Basics Of Muscarinic Physiology -- Airway Muscarinic Receptors -- Applied Clinical Research -- Anticholinergic Agents As Bronchodilators -- Anticholinergic Drug Therapy In The Management Of Acute Severe Asthma -- Use Of Anticholinergics In Perinnial Rhinitis -- Pathogenesis And Treatment Of Upper Respiratory Infections -- Anticholinergics In Combination Bronchodilator Therapy In Copd -- Tiotropium (ba 769): Pharmacology And Early Clinical Observations -- Topics Of Special Interest -- Historical Aspects Of Medicinal Uses Of Antimuscarinics -- Interaction Of Virus With The Muscarinic Receptor. Edited By Sheldon L. Spector. Includes Bibliographical References And Indexes. Discusses anticholinergic agents, integrating the treatment of rhinitis, the common cold and asthma in the upper and lower airways, while updating up-to-date therapeutic practices. The text features assessments of soon-to-be-available medications at the time of publication Anticholinergic drugs have utility-regulating smooth muscle tone and glandular secretion in chronic obstructive pulmonary disease, asthma, allergic rhinitis, and sinusitis.