Lung Biology in Health & Disease Volume 120 Five-Lipoxygenase Products in Asthma

Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma ·highlights agents and products of the 5-LO pathway and its relationship to other pathways ·explores the enzymology of the 5-LO pathway with focus on leukotriene transport, degradation, and excretion ·details the role of protein identification in the 5-LO pathway ·describes human cell types that produce leukotrienes and their activation ·outlines pharmacological and binding study evidence for leukotriene receptors ·discusses the recovery of leukotrienes in lung disease ·analyzes leukotriene receptor antagonists and synthesis inhibitors by specific agent ·provides a by entity summary of individual drug information in exercise-induced, allergen-induced, aspirin-induced, and chronic stable asthma ·profiles the use of agents active on the 5-LO pathway in asthma treatment ·and more! With complete discussions of the recovery of leukotrienes in induced and spontaneous asthma and other conditions, Five-Lipoxygenase Products in Asthma, will benefit pulmonologists and pulmonary disease specialists; clinical allergists; internists; chest, intensive care, primary care, and family practice physicians; respiratory therapists; physiologists; pathologists; cell and molecular biologists; and graduate and medical school students in these disciplines. Overview Of The 5-lipoxygenase Pathway / Jesper Z. Haeggstrom And Bengt Samuelson -- 5-lipoxygenase And 5-lipoxygenase-activating Protein / Jilly F. Evans -- Leukotriene C4 Synthase : A Pivotal Enzyme In The Biosynthesis Of Cysteinyl Leukotrienes / John F. Penrose And K. Frank Austen -- Leukotriene A4 Hydrolase / Jesper Z. Haeggstrom -- Leukotriene Export In Human Leukocytes / Bing K. Lam -- Pathways Of Leukotriene Metabolism In Isolated Cell Models And Human Subjects / Robert C. Murphy And Pat Wheelan -- Cell Biology Of The 5-lipoxygenase Pathway Amplification And Generation Of Leukotrienes And Lipoxins By Transcellular Biosynthesis / Timothy D. Bigby, Bruce D. Levy, And Charles N. Serhan -- Leukotriene Receptors: Incompletely Defined Targets For Treatment Of Asthma And Inflammation / Sven-erik Dahlen -- Physiological Effects Of The Leukotrienes In Humans / Neil C. Barnes And Lewis J. Smith -- Analysis Of Leukotrienes And Lipoxins / Graham W. Taylor -- Measurement Of Leukotrienes From Human Biological Fluids / Jay W. Westcott And Ian K. Taylor -- Cysteinyl-leukotriene Receptor Antagonism And 5-lipoxygenase Inhibition In Asthma / S.m. Shuaib Nasser And Tak H. Lee -- Leukotriene Receptor Antagonism And Synthesis Inhibition In Chronic Stable Asthma / Elliot Israel And Jeffrey M. Drazen -- Montelukast : An Antileukotriene Treatment For Asthma : Changing The Asthma-treatment Paradigm / Beth C. Seidenberg And Theodore F. Reiss -- Pranlukast : The First Orally Active Cysteinyl Leukotriene Receptor Antagonist Marketed For The Treatment Of Asthma / Jeffrey W. Dubb And Anthony S. Rebuck -- Zafirlukast / Catherine M. Bonuccelli And Trevor J.c. Higgins -- Zileuton : The First Leukotriene Synthesis Inhibitor For Use In The Management Of Chronic Asthma / Louise M. Dube [and Others] -- Antileukotrienes In The Management Of Asthma / Paul M. O'byrne. Edited By Jeffrey M. Drazen, Sven-erik Dahlén, Tak H. Lee. Includes Bibliographical References And Index. "Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthmahighlights agents and products of the 5-LO pathway and its relationship to other pathways explores the enzymology of the 5-LO pathway with focus on leukotriene transport, degradation, and excretion details the role of protein identification in the 5-LO pathway describes human cell types that produce leukotrienes and their activation outlines pharmacological and binding study evidence for leukotriene receptors discusses the recovery of leukotrienes in lung disease analyzes leukotriene receptor antagonists and synthesis inhibitors by specific agent provides a by entity summary of individual drug information in exercise-induced, allergen-induced, aspirin-induced, and chronic stable asthma profiles the use of agents active on the 5-LO pathway in asthma treatment and more! With complete discussions of the recovery of leukotrienes in induced and spontaneous asthma and other conditions, Five-Lipoxygenase Products in Asthma, will benefit pulmonologists and pulmonary disease specialists; clinical allergists; internists; chest, intensive care, primary care, and family practice physicians; respiratory therapists; physiologists; pathologists; cell and molecular biologists; and graduate and medical school students in these disciplines."--Provided by publisher INTRODUCTION......Page 11 PREFACE......Page 13 CONTRIBUTORS......Page 15 CONTENTS......Page 19 Overview of the 5-Lipoxygenase Pathway......Page 27 5-Lipoxygenase and 5-Lipoxygenase–Activating Protein......Page 37 Leukotriene C4 Synthase......Page 59 Leukotriene A4 Hydrolase......Page 77 Leukotriene Export in Human Leukocytes......Page 103 Pathways of Leukotriene Metabolism in Isolated Cell Models and Human Subjects......Page 113 Cell Biology of the 5-Lipoxygenase Pathway......Page 151 Leukotriene Receptors: Incompletely Defined Targets for Treatment of Asthma and Inflammation......Page 201 Physiological Effects of the Leukotrienes in Humans......Page 219 Analysis of Leukotrienes and Lipoxins......Page 237 Measurement of Leukotrienes from Human Biological Fluids......Page 271 Cysteinyl-Leukotriene Receptor Antagonism and 5-Lipoxygenase Inhibition in Asthma......Page 309 Leukotriene Receptor Antagonism and Synthesis Inhibition in Chronic Stable Asthma......Page 333 Montelukast—An Antileukotriene Treatment for Asthma......Page 353 Pranlukast—The First Orally Active Cysteinyl Leukotriene Receptor Antagonist Marketed for the Treatment of Asthma......Page 373 Zafirlukast......Page 391 Zileuton: The First Leukotriene Synthesis Inhibitor for Use in the Management of Chronic Asthma......Page 417 Antileukotrienes in the Management of Asthma......Page 455 AUTHOR INDEX......Page 465 SUBJECT INDEX......Page 507 Offers an examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. This book explores the enzymology of the 5-LO pathway with focus on leukotriene transport, degradation, and excretion. It is for respiratory therapists; physiologists; pathologists; and others. Lipoxygenases are enzymes that catalyze a stereospecific dehydrogenation and subsequent dioxygenation of polyunsaturated fatty acids with a 1,4-cis-pentadiene structure. This work offers an examination of the biochemistry, basic pharmacology and clinical pharmacology of the leukotrienes, with special emphasis on their role in asthma