Lung Biology in Health and Disease Volume 95 Tissue Oxygen Deprivation - From Molecular to Integrated Function

Detailing the importance of hypoxia in the expression, genesis, and propagation of human illness - this state-of-the-art reference summarizes current knowledge of responses to hypoxia in a variety of organ systems and in a number of vital processes common to all systems - addressing the effect of oxygen deprivation on fundamental processes such as cellular energetics, ion transport, and receptor function. Organized by cellular and subcellular processes and the effects of hypoxia on these processes, Tissue Oxygen Deprivation raises insightful questions and suggests unique approaches to the study of different types of hypoxic injury...highlights important gaps in our understanding of hypoxia...examines the effect of O[subscript 2] deprivation on the brain, heart, lung, and peripheral systems...elucidates the pathogenesis and consequences of hypoxia and ischemia...investigates advances in gene regulation...emphasizes the influence of development or maturation on responses to hypoxia...discusses the mechanisms of free radical production during reoxygenation...and more Introduction / Claude Lenfant -- 1. Hypoxia: Historical Perspective And Unresolved Issues / Abraham M. Rudolph -- 2. Cellular Energetics And Biochemistry Of Hypoxia / Dean P. Jones -- 3. Atp Supply And Demand: Models And Insights / Peter W. Hochachka -- 4. Membrane Proteins And Transport During Oxygen Deprivation / Gabriel G. Haddad -- 5. Gene Regulation During Hypoxia / Bruce R. Pitt, Margaret A. Schwarz And Paul Davies -- 6. Erythropoietin Response To Hypoxia / Christian M. Bauer -- 7. The Spectrin-actin Cytoskeleton And Membrane Integrity In Hypoxia / Susan B. Glantz And Jon S. Morrow -- 8. Membrane Receptors And Second Messengers In Hypoxia / Daniel Bernstein -- 9. Hypoxia-induced Changes In The Contraction, Growth, And Matrix Synthetic Properties Of Vascular Cells / Edward C. Dempsey, Troy Stevens, Anthony G. Durmowicz And Kurt R. Stenmark -- 10. Free Radicals In Hypoxia And Reoxygenation / Clifford S. Collis And Catherine Rice-evans. Edited By Gabriel G. Haddad, George Lister. Includes Bibliographical References And Indexes.