Lung Biology in Health and Disease Volume 179 Acute Respiratory Distress Syndrome

Forty-seven international specialists contribute 23 chapters documenting recent progress made in the research of the acute respiratory distress syndrome (ARDS) and clinical acute lung injury (ALI) at the molecular, cellular, and physiological levels, and current pharmacological and ventilatory appro 1. Overview / Thomas L. Petty 2. Definitions and clinical risk factors / Marc Moss and B. Taylor Thompson 3. Epidemiology of acute lung injury: a public health perspective / Gordon D. Rubenfeld and Margaret J. Neff 4. Radiographic findings of the acute respiratory distress syndrome / Desireé M. Quiñones, Maymi and Philip C. Goodman 5. Pulmonary pathology of the acute respiratory distress syndrome: diffuse alveolar damage / Joseph F. Tomashefski, Jr. 6. Pathogenesis of acute lung injury: experimental studies / Nicholas David Manzo and Aaron B. Waxman 7. Pathogenesis of acute lung injury: clinical studies / Lorraine B. Ware and Timothy W. Evans 8. Is apoptosis important in the pathogenesis and resolution of the acute respiratory distress syndrome? / Gustavo Matute-Bello and Thomas R. Martin 9. Pathogenesis of ventilator-induced lung injury / James A. Frank, Yumiko Imai, and Arthur S. Slutsky 10. Pathogenesis of sepsis and septic-induced lung injury / Guy A. Zimmerman, Kurt H. Albertine, and Thomas M. McIntyre 11. Heat shock response, heat shock proteins, and acute lung injury / Hyon Lee, Michaela C. Godzich, and Jean-Franc̦ois Pittet 12. Mechanisms of fibroproliferation in acute lung injury / Mitchell A. Olman 13. Genetic factors in acute lung injury / Richard P. Marshall 14. Approach to the genetic epidemiology of acute lung injury / Michelle Ng Gong and David C. Christiani 15. Resolution of alveolar edema: mechanisms and relationship to clinical acute lung injury / Michael A. Matthay ... [et al.] 16. Sepsis in the acute respiratory distress syndrome: treatment implications / Arthur P. Wheeler and Gordon R. Bernard 17. Modulation of pulmonary vascular tone in the acute respiratory distress syndrome / Udo Kaisers ... [et al.] 18. Glucocorticoid therapy for the acute respiratory distress syndrome / Richard B. Goodman and Leonard D. Hudson 19. Surfactant therapy in the acute respiratory distress syndrome / Roger G. Spragg and James F. Lewis 20. Prone position in the acute respiratory distress syndrome / Antonio Anzueto and Luciano Gattinoni 21. Mechanical ventilation in the acute respiratory distress syndrome / Roy G. Brower and Laurent J. Brochard 22. Severe acute respiratory syndrome / Lorraine B. Ware 23. Acute lung injury: recent progress and promising directions for future research / Michael A. Matthay. Book Cover......Page 1 Half-Title......Page 2 Series-Title......Page 3 Title......Page 14 Copyright......Page 15 Introduction......Page 16 Preface......Page 17 Contributors......Page 19 Contents......Page 23 1 Overview......Page 27 2 Definitions and Clinical Risk Factors......Page 32 3 Epidemiology of Acute Lung Injury......Page 56 4 Radiographic Findings of the Acute Respiratory Distress Syndrome......Page 70 5 Pulmonary Pathology of the Acute Respiratory Distress Syndrome......Page 88 6 Pathogenesis of Acute Lung Injury......Page 129 7 Pathogenesis of Acute Lung Injury......Page 155 8 Is Apoptosis Important in the Pathogenesis and Resolution of the Acute Respiratory Distress Syndrome?......Page 184 9 Pathogenesis of Ventilator-Induced Lung Injury......Page 204 10 Pathogenesis of Sepsis and Septic-Induced Lung Injury......Page 243 11 Heat Shock Response, Heat Shock Proteins, and Acute Lung Injury......Page 280 12 Mechanisms of Fibroproliferation in Acute Lung Injury......Page 301 13 Genetic Factors in Acute Lung Injury......Page 337 14 Approach to the Genetic Epidemiology of Acute Lung Injury......Page 361 15 Resolution of Alveolar Edema......Page 383 16 Sepsis in the Acute Respiratory Distress Syndrome......Page 407 17 Modulation of Pulmonary Vascular Tone in the Acute Respiratory Distress Syndrome......Page 428 18 Glucocorticoid Therapy for the Acute Respiratory Distress Syndrome......Page 466 19 Surfactant Therapy in the Acute Respiratory Distress Syndrome......Page 485 20 Prone Position in the Acute Respiratory Distress Syndrome......Page 510 21 Mechanical Ventilation in the Acute Respiratory Distress Syndrome......Page 533 22 Severe Acute Respiratory Syndrome......Page 570 23 Acute Lung Injury......Page 581 Index......Page 589 Includes a timely update on the SARS epidemic.The latest volume in the prestigious Lung Biology in Health and Disease series chronicles recent progress made in understanding ARDS at the molecular, cellular, and physiological levels and in discovering pharmacologic and ventilatory approaches to better treat and resolve the condition. Showcases the role of apoptosis in the pathogenesis and resolution of lung injury. New data is presented on the potential role of heat-shock proteins in the pathophysiology of acute lung injury, as well as the influence of genetic factors in determining which patients are most susceptible to the development of this condition.