Lung Biology in Health and Disease Volume 153 Environmental Asthma

Combating the rising prevalence and morbidity of asthma around the globe, this critical reference investigates environmental factors and prescribes preventive measures for the pathogenesis and treatment of asthma. Extensive analyses of allergens and pollutants document the causal relationships between environmental exposure and asthmatic problems. Systematically highlighting numerous environmental determinants, Environmental Asthma ·identifies key methods to recognize, measure, and monitor environmental aspects impacting asthma management ·examines the stages of antigen-induced airway disease, various allergic responses, and the role of inflammatory mediators and cells ·profiles the biology, molecular characteristics, and assessment of dust mite allergens and acute airway responses ·focuses on the relationship between fungal sensitivity and asthma, and details fungal allergens, their environments, and prophylactic procedures ·pinpoints efforts to screen sources of air pollution, including sulfur and nitrogen dioxides, acid aerosols, and ozone ·considers a variety of diagnostic approaches such as pulmonary function testing, radiology, arterial blood gases, and atopy ·explores the objectives, indications, and contraindications of immunotherapy for asthma ·forecasts future directions encompassing risk factors, population studies, and containment ·and much more! Written by renowned experts and containing over 1000 literature references, drawings, photographs, and x-rays, Environmental Asthma is an outstanding reference for pulmonologists, clinical immunologists, allergists, primary care physicians, internists, pediatricians, and medical school students in these disciplines. Cover Page......Page 1 Title Page......Page 2 ISBN 0824703014......Page 3 INTRODUCTION......Page 4 PREFACE......Page 6 CONTRIBUTORS......Page 8 2. Antigen-Induced Airway Disease......Page 12 5. The Role of Fungal Allergens: Assessment and Control......Page 13 8. Indoor Environment and Asthma......Page 14 11. Occupational Asthma: Role of High Molecular Weight Agents......Page 15 14. Speci c Immunotherapy in Asthma......Page 16 15. Future Directions......Page 17 I. Increasing Asthma Prevalence and the Environment......Page 18 II. Immune Mechanisms in Allergic Asthma......Page 19 III. Diagnostic Approaches......Page 20 IV. House Dust Mite Allergens......Page 21 V. Animal Allergens......Page 22 VII. Inner City Problems......Page 23 VIII. Pollen Allergens......Page 24 X. Occupational Asthma......Page 25 XI. Immunotherapy......Page 26 References......Page 27 I. Introduction......Page 30 II. Antigen Sensitization......Page 31 III. The Early-Phase Response......Page 34 V. The Role of In ammatory Mediators......Page 37 VI. The Role of In ammatory Cells......Page 38 VII. Airway Remodeling......Page 40 References......Page 42 I. Introduction......Page 50 II. Taxonomy and Biology of Mites......Page 51 III. Assessment of Mite Allergens......Page 53 IV. Molecular Characteristics of Mite Allergens......Page 54 V. Relationship of Allergen Exposure to Airway Disease Chronic Exposure......Page 57 VI. Acute Airway Response......Page 61 VII. Environmental Control Measures......Page 62 References......Page 63 I. Introduction......Page 70 II. The Allergens......Page 71 III. Environmental Distribution......Page 73 IV. Clinical Aspects......Page 75 V. Environmental Control of Animal Allergens......Page 77 VI. Immunotherapy......Page 79 References......Page 80 I. Introduction......Page 86 II. Prevalence of Fungal Sensitivity......Page 88 III. Association of Fungal Sensitivity with Asthma......Page 90 IV. Asthma and Fungi in the Indoor Environment......Page 92 V. Fungal Species Found in Indoor Environments......Page 95 VI. Fungal Allergens......Page 98 VII. Fungal Cell Wall Components and Their Relation to Asthma......Page 99 VIII. Assessment of Fungal Allergen Exposure......Page 100 IX. Fungal Allergen Avoidance Measures......Page 101 XI. Summary......Page 102 References......Page 103 I. Introduction......Page 108 II. Nature and Travels of Airborne Pollen......Page 109 III. Pollen Allergens and Their Distribution......Page 112 IV. Evaluation of Exposure......Page 119 V. The Case for Pollen-Induced Asthma......Page 121 VI. Prevention and Mitigation of Pollen-Related Asthma......Page 123 References......Page 129 I. Introduction......Page 136 II. Sulfur Dioxide and Acid Aerosols......Page 137 III. Nitrogen Dioxide......Page 139 IV. Ozone......Page 141 V. Particulate Matter......Page 145 References......Page 148 I. Introduction......Page 158 II. Determinants of the Air in Indoor Environments......Page 160 III. Terminology......Page 161 IV. The Modern Indoor Environment and Asthma......Page 162 V. Why There Are Problems with Indoor Air Quality......Page 164 VI. Environmental Hygienics: Ef ciency, Comfort, and Health......Page 176 References......Page 178 I. Introduction......Page 182 II. Estimating Exposures Relevant to Asthma......Page 183 III. Risk Factors for Asthma in Urban Populations......Page 184 References......Page 192 I. Introduction......Page 200 III. Differential Diagnosis......Page 201 IV. Pulmonary Function Testing......Page 202 V. Radiology......Page 210 VII. Other Testing......Page 212 VIII. Atopy......Page 213 IX. Summary......Page 216 References......Page 217 II. Frequency......Page 222 III. Common High Molecular Weight Agents Causing Occupational Asthma......Page 223 IV. Asthma Caused by High Molecular Weight Agents as a Satisfactory Model for Common Asthma......Page 226 References......Page 233 Appendix: High Molecular Weight Agents Causing Occupational Asthma......Page 239 Appendix......Page 241 I. Introduction......Page 256 II. Nonimmunological Asthma: Reactive Airways Dysfunction Syndrome......Page 257 III. Immunological Asthma......Page 258 References......Page 271 I. Introduction......Page 282 II. Occupational History......Page 283 III. Differential Diagnosis......Page 288 IV. Immunological Assessment......Page 289 V. Physiological Assessment......Page 291 VI. Clinical Assessment of Occupational Asthma......Page 294 VIII. Prevention......Page 298 References......Page 299 I. Introduction......Page 302 II. Objectives of Immunotherapy......Page 303 III. Mechanisms of SIT in Asthma......Page 304 V. Ef cacy and Safety of Subcutaneous SIT......Page 308 VI. Other Routes for Allergen Administration......Page 315 VIII. Can Immunotherapy Alter the Course of Asthma?......Page 317 IX. Indications and Contraindications of Immunotherapy in Asthma According to Recent International Guidelines......Page 318 X. Future Trends......Page 323 References......Page 324 I. Introduction......Page 338 III. Risk Factors......Page 339 IV. Population Studies......Page 340 VI. Exposure Assessment......Page 341 VII. Do Control Measures Work?......Page 342 IX. Conclusion......Page 343 References......Page 344 A......Page 346 B......Page 347 C......Page 350 D......Page 353 F......Page 355 G......Page 357 H......Page 358 J......Page 361 K......Page 362 L......Page 363 M......Page 366 N......Page 369 O......Page 370 P......Page 371 R......Page 373 S......Page 374 T......Page 378 V......Page 379 W......Page 380 Y......Page 382 Z......Page 383 D......Page 384 I......Page 385 P......Page 386 W......Page 387 Back Page......Page 388

combating The Rising Prevalence And Morbidity Of Asthma Around The Globe, This Critical Reference Investigates Environmental Factors And Prescribes Preventive Measures For The Pathogenesis And Treatment Of Asthma. Extensive Analyses Of Allergens And Pollutants Document The Causal Relationships Between Environmental Exposure And Asthmatic Problems.
systematically Highlighting Numerous Environmental Determinants, Environmental Asthma
• Identifies Key Methods To Recognize, Measure, And Monitor Environmental Aspects Impacting Asthma Management
• Examines The Stages Of Antigen-induced Airway Disease, Various Allergic Responses, And The Role Of Inflammatory Mediators And Cells
• Profiles The Biology, Molecular Characteristics, And Assessment Of Dust Mite Allergens And Acute Airway Responses
• Focuses On The Relationship Between Fungal Sensitivity And Asthma, And Details Fungal Allergens, Their Environments, And Prophylactic Procedures
• Pinpoints Efforts To Screen Sources Of Air Pollution, Including Sulfur And Nitrogen Dioxides, Acid Aerosols, And Ozone
• Considers A Variety Of Diagnostic Approaches Such As Pulmonary Function Testing, Radiology, Arterial Blood Gases, And Atopy
• Explores The Objectives, Indications, And Contraindications Of Immunotherapy For Asthma
• Forecasts Future Directions Encompassing Risk Factors, Population Studies, And Containment
• And Much More!
written By Renowned Experts And Containing Over 1000 Literature References, Drawings, Photographs, And X-rays, Environmental Asthma Is An Outstanding Reference For Pulmonologists, Clinical Immunologists, Allergists, Primary Care Physicians, Internists, Pediatricians, And Medical School Students In These Disciplines.

doody Review Services

reviewer:kathleen F. Maurer, Md, Mph(hartford Hospital)
description:this Volume In The Lung Biology In Health And Disease Series Covers Environmental Asthma.
purpose:the Purpose Is To Provide A Comprehensive Yet Readable Survey Of Research And Clinical Issues Involving Environmental Exposure And Its Relationship To Asthma. Edited By Robert K. Bush And Organized Into 15 Chapters, The Subject Matter Ranges Widely. Several Of The Topics Include The Current Scientific Understanding Of The Etiology And Pathogenesis Of Asthma, The Role Of A Variety Of Occupational And Environmental Exposures In The Pathogenesis Of Asthma, Asthma Treatment Modalities, And An Introduction To The Controversies Surrounding Immunotherapy In The Treatment Of Asthma.
audience:for A Clinician, Student, Or Physician In Training, This Book Provides An Excellent Introduction To The Relationship Of Environmental Exposure And Asthma.
features:the Strength Of This Volume Lies In Its Breadth Of Coverage Of Not Only Environmental Asthma, But Also The Current Scientific Understanding Of The Pathogenic Mechanisms Of The Disease And Its Attention To Clinical Care. Although Not Designed As A Comprehensive Reference Tool, Each Chapter Is Remarkably Thoroughly Referenced.
assessment:the Author's Attention To The Medical Evaluation Of The Asthmatic Patient And The Role Of The Occupational And Environmental History Will Be Especially Useful To The Practicing Physician. As The Prevalence Of Asthma Increases, Effective Means Of Disease Treatment And Intervention Become Increasingly Important. Understanding The Role Of Environmental And Occupational Exposures In The Development And Course Of This Disease, And How To Address Those Impacts From A Clinical Perspective Are Extremely Useful Contributions Of This Volume. This Book Presents An Excellent And Comprehensive Review Of The Current Scientific Literature On Its Subject. While Its Research-focused Content Is Rewarding To Read, The Authors' Abilities To Successfully Integrate Clinical Information With Scientific Research Makes This An Outstanding Text That Is Of Value To A Wide Range Of Medical Practitioners. That The Volume Achieves This Meaningful Practical Application Speaks Highly Of Its Editors And Many Contributors.