Lung And Heart-lung Transplantation (lung Biology In Health And Disease)

A comprehensive review of clinical and exploratory aspects of lung (LT) and heart-lung transplantation (HLT), this reference focuses on cumulative data from the International Registry with data on outcomes associated with LT and HLT worldwide. Collecting in-depth discussions on graft dysfunction, infectious complications, and indications of LT for specific disease states including emphysema, cystic fibrosis, myriad interstitial lung diseases, and pulmonary hypertension, this guide explores the most current technologies and best practices affecting lung and heart-lung transplant surgeries Front Cover......Page 1 Introduction......Page 14 Preface......Page 16 Contributors......Page 22 Contents......Page 30 1. Historical Overview of Lung and Heart–Lung Transplantation......Page 44 2. Basic Immunological Concepts in Lung Transplantation: The Role of Regulatory T Cells and Dendritic Cells......Page 64 3. Allogeneic Recognition and Immune Tolerance in Lung Transplantation......Page 90 4. Lung Transplantation for Chronic Obstructive Pulmonary Disease......Page 104 5. Lung Transplant in Cystic Fibrosis......Page 164 6. Pulmonary Arterial Hypertension and Lung Transplantation......Page 190 7. Lung Transplantation for Interstitial Lung Disorders......Page 208 8. Pulmonary Langerhans Cell Histiocytosis and Lymphangioleiomyomatosis......Page 248 9. Pediatric Lung Transplantation......Page 276 10. Living Lobar Lung Transplantation......Page 298 11. Heart–Lung Transplantation: Is It a Viable Option in the 21st Century?......Page 312 12. Lung Allocation in the United States......Page 328 13. Organ Allocation and Donor Availability—The European Experience......Page 344 14. Allocation of Donor Organs for Lung Transplantation: The Australian Experience......Page 350 15. Lung Preservation Techniques......Page 368 16. Operative Techniques Utilized in Lung Transplantation and Strategies to Increase the Donor Pool......Page 392 17. Immunosuppressive Drugs: Cyclosporine, Tacrolimus, Sirolimus, Azathioprine,Mycophenolate Mofetil, and Corticosteroids......Page 406 18. Lympholytic Agents (Polyclonal Antilymphocyte Antibodies, Anti-CD3 Monoclonal Antibodies, Anti-CD25 Monoclonal Antibodies)......Page 444 19. Novel and Future Approaches to Immunosuppression......Page 464 20. Primary Graft Dysfunction Following Lung Transplantation: Pathogenesis and Impact on Early and Late Outcomes......Page 480 21. Airway Complications in Lung Transplantation......Page 508 22. Viral Infections Complicating Lung and Solid Organ Transplantation......Page 528 23. Coccidioidomycosis After Solid Organ Transplantation......Page 570 24. Histoplasmosis and Blastomycosis After Solid Organ Transplantation......Page 592 25. Invasive Fungal Infections Complicating Lung and Solid Organ Transplantation: Aspergillosis, Cryptococcosis, and Molds......Page 600 26. Bacterial Infections and Pneumocystis Infections......Page 630 27. Legionella in Solid Organ Transplantation......Page 650 28. Mycobacterial Infections Complicating Organ Transplantation......Page 666 29. Acute Allograft Rejection......Page 704 30. Pathology of the Lung Transplant......Page 726 31. Obliterative Bronchiolitis......Page 766 32. The Role for Alloimmune and Nonalloimmune Injury and Cytokine Responses in the Pathogenesis of Bronchiolitis Obliterans Syndrome......Page 796 33. Pulmonary Physiology Posttransplant......Page 832 34. Imaging of the Posttransplant Lung......Page 866 35. Cardiac, Lipid, and Atherosclerotic Complications Among Lung and Heart–Lung Recipients......Page 924 36. Metabolic Bone Disease in Lung Transplant Recipients......Page 938 37. Lymphoproliferative Disorders Complicating Solid Organ Transplantation......Page 944 Index......Page 978 A comprehensive review of clinical and exploratory aspects of lung (LT) and heart-lung transplantation (HLT), this reference focuses on cumulative data from the International Registry with data on outcomes associated with LT and HLT worldwide. Collecting in-depth discussions on graft dysfunction, infectious complications, and indications for LT for specific disease states including emphysema, cystic fibrosis, myriad interstitial lung diseases, and pulmonary hypertension, this guide explores the most current technologies and best practices affecting lung and heart-lung transplant surgeries