Local Therapies for Glioma: Present Status and Future Developments (Acta Neurochirurgica Supplement Book 88)

In addition to surgery and radiotherapy, local treatment modalities for the management of brain tumours are increasingly being developed and clinically tested. This book describes for the first time basic tumour biology as well as all current procedures in progress at the most recent level of knowledge, presented by leading experts in the respective fields. Image guided resection procedures, fluorescence guided surgery, developments in interstitial radiosurgery are addressed, just as intracavitary chemotherapy and all current concepts and studies of interstitial targeted therapy. Owing to its topicality this book will remain for long the standard for this comprehensively treated subject. Front Matter....Pages I-IX Intraoperative imaging — MRI....Pages 1-4 Stereotactic volumetric resection of gliomas....Pages 5-8 Fluorescence-guided resections of malignant gliomas — an overview....Pages 9-12 Postoperative Imaging after Brain Tumor Resection....Pages 13-20 Preliminary Experience in Glioma Surgery with Intraoperative High-Field MRI....Pages 21-29 Awake Craniotomy in Glioma Surgery....Pages 31-35 External beam and conformal radiotherapy in the management of gliomas....Pages 37-43 Interstitial stereotactic radiosurgery....Pages 45-50 Implantable drug-releasing biodegradable microspheres for local treatment of brain glioma....Pages 51-55 Non-invasive transcranial High Intensity Focused Ultrasound (HIFUS) under MRI thermometry and guidance in the treatment of brain lesions....Pages 57-60 Intracavitary Chemotherapy for Glioblastoma: Present Status and Future Directions....Pages 61-67 Intralesional radioimmunotherapy in the treatment of malignant glioma: clinical and experimental findings....Pages 69-75 Intracavitary Treatment of Malignant Gliomas: Radioimmunotherapy Targeting Fibronectin....Pages 77-82 Comparing monoclonal antibodies and small peptidic hormones for local targeting of malignant gliomas....Pages 83-91 Local convection enhanced delivery of IL4-Pseudomonas exotoxin (NBI-3001) for treatment of patients with recurrent malignant glioma....Pages 93-103 Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies....Pages 105-111 Oncolytic viruses for treatment of malignant brain tumours....Pages 113-123 Gene therapy of gliomas....Pages 125-135 Cell therapy using encapsulated cells producing endostatin....Pages 137-141 Stem cells in neuro-oncology — development, regeneration and treatment....Pages 143-151 Glioma invasion — Pattern of dissemination by mechanisms of invasion and surgical intervention, pattern of gene expression and its regulatory control by tumorsuppressor p53 and proto-oncogene ETS-1....Pages 153-162 Mechanisms of glioma cell invasion....Pages 163-167 Invasion as limitation to anti-angiogenic glioma therapy....Pages 169-177 Back Matter....Pages 179-186