Lipids in Health and Disease (Subcellular Biochemistry (49))

This volume gives an up-to-date account of the properties of the classes of lipids that are located in the membranes of all cells. These lipids form the essential structural components of the plasma membrane responsible for maintaining the distinct identity of the cell from its surroundings and mediating the flow of vital solutes into and out of the cell. The membrane lipids also represent reservoirs of signaling molecules that modulate a variety of physiological processes. The presentation gives a balanced perspective of what is currently known about the function of these lipids in healthy cells and tissues and what consequences follow malfunctions in their synthesis and metabolism. Contents......Page 12 Contributors......Page 15 Part I: Fatty Acids......Page 20 1. Transcriptional Regulation of Hepatic Fatty Acid Metabolism......Page 21 2. Modulation of Protein Function by Isoketals and Levuglandins......Page 66 3. Signalling Pathways Controlling Fatty Acid Desaturation......Page 88 4. Fatty Acid Amide Hydrolase: A Gate-Keeper of the Endocannabinoid System......Page 117 5. Modulation of Inflammatory Cytokines by Omega-3 Fatty Acids......Page 149 6. Eicosanoids in Tumor Progression and Metastasis......Page 160 7. Fatty Acid Synthase Activity in Tumor Cells......Page 184 Part II: Phospholipids......Page 210 8. Lipids in the Assembly of Membrane Proteins and Organization of Protein Supercomplexes: Implications for Lipid-linked Disorders......Page 211 9. Altered Lipid Metabolism in Brain Injury and Disorders......Page 254 10. Lysophospholipid Activation of G Protein-Coupled Receptors......Page 282 11. Phospholipid-Mediated Signaling and Heart Disease......Page 311 12. The Role of Phospholipid Oxidation Products in Inflammatory and Autoimmune Diseases: Evidence from Animal Models and in Humans......Page 337 13. Mediation of Apoptosis by Oxidized Phospholipids......Page 363 Part III: Sphingolipids......Page 380 14. Regulation of Lipid Metabolism by Sphingolipids......Page 381 15. Multiple Roles for Sphingolipids in Steroid Hormone Biosynthesis......Page 396 16. Roles of Bioactive Sphingolipids in Cancer Biology and Therapeutics......Page 422 17. Glycosphingolipid Disorders of the Brain......Page 450 18. Role of Neutral Sphingomyelinases in Aging and Inflammation......Page 477 19. Sphingolipid Metabolizing Enzymes as Novel Therapeutic Targets......Page 495 20. Ceramide-Enriched Membrane Domains in Infectious Biology and Development......Page 531 Part IV: Lipidomics......Page 547 21. MALDI-TOF MS Analysis of Lipids from Cells, Tissues and Body Fluids......Page 548 22. Lipidomics in Diagnosis of Lipidoses......Page 573 B......Page 595 C......Page 596 F......Page 597 I......Page 598 L......Page 599 O......Page 600 P......Page 601 S......Page 602 Z......Page 603 This volume provides an up-to-date account of the properties of the classes of lipids that are located in the membranes of all cells. It gives a balanced perspective of what is currently known about the function of these lipids in healthy cells and tissues and what consequences follow malfunctions in their synthesis and metabolism Offers an account of the properties of the classes of lipids that are located in the membranes of various cells. This title presents a balanced perspective of what is known about the function of these lipids in healthy cells and tissues and what consequences follow malfunctions in their synthesis and metabolism