Lipid metabolism in the normoxic and ischaemic heart

Scientific progress with respect to the important role of various lipids in myocardial function and the dearrangements of lipid metabolism underlying ischaemic heart disease(s) has been con­ siderable in recent years. In 1986 alone, an overall number ofl 044 full papers covering the topics "Lipids-Heart-Heart Disease", have been published in a variety of biochemistry, physiology, pharmacology and cardiology journals (source: Index Medicus). They have broadened our in­ sight into the molecular basis of myocardial lipidology and the lipido-chemical basis of car­ diology in health and disease, and have narrowed the gap between promising pharmacological intervention in experimental animals and clinical treatment of patients suffering from an ischaemic heart. Furthermore, they illustrate the fundamental significance of the product of the union between basic and clinical science. The rapid development of knowledge in the "Lipids-Heart-Heart Disease" triad prompted us to organize the International Symposium on Lipid Metabolism in the Normoxic and lschaemic Heart, held in Rotterdam (The Netherlands) on September 22 and 23, 1986. This meeting was a coproject of the Department of Biochemistry I (Medical Faculty, Erasmus University Rotter­ dam) and the Department of Physiology (Medical Faculty, University of Limburg) and was held under the auspices of the GerritJan Mulder Foundation (named after a famous Rotterdam physi­ cian and chemist who lived from 1802-1880) whom we thank for their co-operation. The present volume is a compendium of invited papers and contributions selected from the posters presented during the symposium. Front Matter....Pages I-IX Front Matter....Pages 1-1 Substrates for energy metabolism in the heart: the role of the interstitial compartment....Pages 3-9 Uptake and transport of lipid substrates in the heart....Pages 11-18 Synthesis, storage and degradation of myocardial triglycerides....Pages 19-28 Stimulation of myocardial neutral triglyceride lipase activity by adenosine-3’:5’-monophosphate: involvement of glycogenolysis....Pages 29-35 Triacylglycerol lipase activities in isolated myocardial cells from chronically diabetic rat hearts....Pages 37-43 Lipoprotein lipase activity in ischaemic and anoxic myocardium....Pages 45-52 Myocardial carnitine transport....Pages 53-62 The role of the carnitine system in myocardial fatty acid oxidation: carnitine deficiency, failing mitochondria and cardiomyopathy....Pages 63-73 The effect of exogenous L-carnitine on biochemical parameters in serum and in heart of the hyperlipidaemic rat....Pages 75-81 Front Matter....Pages 83-83 Physico-chemical properties and organization of lipids in membranes: their possible role in myocardial injury....Pages 85-91 Modulation of membrane protein function by bilayer lipids....Pages 93-97 Serum factors which alter cell membranes....Pages 99-105 Phospholipases of the myocardium....Pages 107-112 Phospholipid alterations in canine cardiac sarcoplasmic reticulum induced by an acid-active phospholipase C....Pages 113-119 Membrane phospholipid metabolism during myocardial ischaemia: past, present and future....Pages 121-125 The effects of ischaemia, lysophosphatidylcholine and palmitoylcarnitine on rat heart phospholipase A 2 activity....Pages 127-135 Cholesterol and myocardial membrane function....Pages 137-145 Front Matter....Pages 147-147 Lipid and carbohydrate metabolism in the ischaemic heart....Pages 149-153 Metabolic disturbances during acute lack of oxygen: a short overview....Pages 155-155 Accumulation of lipids and lipid-intermediates in the heart during ischaemia....Pages 157-167 Front Matter....Pages 147-147 Free fatty acid metabolism in “stunned” myocardium....Pages 169-176 Raised plasma non-esterified fatty acids (NEFA) during ischaemia: implications for arrhythmias....Pages 177-186 Detrimental actions of endogenous fatty acids and their derivatives. A study of ischaemic mitochondrial injury....Pages 187-196 Front Matter....Pages 197-197 Lysophospholipids, long chain acylcarnitines and membrane dysfunction in the ischaemic heart....Pages 199-208 Dietary fatty acids and myocardial function....Pages 209-221 The effects of dietary mackerel oil on the recovery of cardiac function after acute ischaemic events in the pig....Pages 223-234 Eicosanoids and myocardial ischaemia....Pages 235-243 Influence of intracellular Ca 2+ -overload in eicosanoid synthesis of the myocardium....Pages 245-251 Lipid peroxidation and myocardial ischaemic damage: cause or consequence?....Pages 253-260 Effects of free fatty acids, lysophosphatides and phospholipase treatment on lipid peroxidation of myocardial homogenates and membrane fractions....Pages 261-269 Back Matter....Pages 271-274