Lipid metabolism in the healthy and disease[d] heart

The Third International Symposium on Lipid Metabolism in the Normoxic and Ischemic Heart was held in Rotterdam, the Netherlands, September 9-10, 1991. The topics of this meeting were focused on: 1. Modulation of myocardial lipid metabolism, 2. Biological membranes; structure, functiona and turnover, 3. Pharmacological modification of myocardial fatty acid oxidation, 4. Myocardial vascular endothelium; contribution to myocardial lipid homeostasis. Special attention is given to the interrelationship between carbohydrates and fatty acids as energy substrates for the heart under normoxic and (post) ischemic circumstances, the influence of diets, varying in their fatty acid composition, on cardiac function, and the significance of phospholipid topology, turnover, and methylation in general and the phosphatidylinositol pathway in particular on performance of the heart. The role of carnitine in cardiac function altered by lack of oxygen or by elevated levels of fatty acyl derivatives of carnitine and the modulatory effects of the endothelium on cardiac lipid homeostasis were also extensively discussed during the conference. This focused Issue of Molecular and Cellular Biochemistry is a collection of invited papers based on the lectures and a selection of posters presented during the meeting. It includes contributions of renowned investigators delineating recent results and discussing significant aspects of their data in an attempt to enlarge our insight in the complexity of cardiac lipid transport and metabolism, in the healthy and diseased myocardium. Front Matter....Pages i-vi Paradoxical role of lipid metabolism in heart function and dysfunction....Pages 3-9 Interrelationship between lactate and cardiac fatty acid metabolism....Pages 11-17 Dietary modulation of lipid metabolism and mechanical performance of the heart....Pages 19-25 The substrate specificity of phosphoinositide- phospholipase C in rat heart sarcolemma....Pages 27-31 Long term Incubation of Cardiac Myocytes with Oleic Acid and Very-low Density Lipoprotein Reduces Heparin-releasable Lipoprotein Lipase Activity....Pages 33-37 Carnitine Palmitoyltransferase in the Heart is Controlled by a Different Mechanism than the Hepatic Enzyme....Pages 39-45 Myocardial cell vulnerability to exogenous phospholipase attack....Pages 47-52 Phosphatidylcholine metabolism in ischemic and hypoxic hearts....Pages 53-58 Occurrence and Functions of the Phosphatidylinositol Cycle in the Myocardium....Pages 59-67 Modulation of Phosphatidylethanolamine Biosynthesis by Exogenous Ethanolamine and Analogues in the Hamster Heart....Pages 69-73 Eicosapentaenoic and Docosahexaenoic Acids in Cultured Rat Ventricular Myocytes and Hypoxia-induced Alterations of Phospholipase-A Activity....Pages 75-78 Incorporation of Radioiodinated Fatty Acids into Cardiac Phospholipids of Normoxic Canine Myocardium....Pages 79-87 Kinetic changes of ethanolamine base exchange activity and increase of viscosity in sarcolemmal membranes of hamster heart during development of cardiomyopathy....Pages 89-93 Annexins in cardiac tissue: cellular localization and effect on phospholipase activity....Pages 95-101 Myocardial fatty acid oxidation during ischemia and reperfusion....Pages 103-109 The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia....Pages 111-116 Effects of palmitoyl CoA and palmitoyl carnitine on the membrane potential and Mg 2+ content of rat heart mitochondria....Pages 117-123 Carnitine requirement of vascular endothelial and smooth muscle cells in imminent ischemia....Pages 125-129 Protection of the ischemic diabetic heart by L-propionylcarnitine therapy....Pages 131-137 Functional and metabolic effects of propionyl-L-carnitine in the isolated perfused hypertrophied rat heart....Pages 139-145 L-propionylcarnitine and myocardial performance in stunned porcine myocardium....Pages 147-153 Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man....Pages 155-162 Regulatory functions of the coronary endothelium....Pages 163-169 Lipid metabolism of myocardial endothelial cells....Pages 171-179 Endothelium, the dynamic interface in cardiac lipid transport....Pages 181-191 Malondialdehyde is a biochemical marker of peroxidative damage in the isolated reperfused rat heart....Pages 193-196 Studies on the interaction of leucocytes and the myocardial vasculature....Pages 197-202 Arachidonic acid incorporation in cardiomyocytes, endothelial cells and fibroblast-like cells isolated from adult rat heart....Pages 203-209 Back Matter....Pages 211-213 Proceedings of the Third International Symposium on Lipid Metabolism in the Normoxic and Ischemic Heart, September 9 & 10, 1991, Rotterdam, The Netherlands