Limitation of infarct size [proceedings of a symposium held in Berlin, June 1987

Effective treatment of acute myocardial infarction remains one of the major issues in cardiology and internal medicine. The present monograph summarizes the relevant experimental data and the results of major clinical trials in the treatment of myocardial infarction. There are contributions of fundamental anatomical and physiological concepts of vascular occlusion and myocardial damage due to ischemia as well as discussions of therapeutic strategies involving thrombolytic agents, adjuvant drug therapy for limitation of myocardial damage, improvement in myocardial tolerance to ischemia and prevention of coronary reocclusion. In this regard, there is an extensive discussion of the role of coronary angioplasty and bypass surgery in the setting of acute myocardial infarction. Front Matter....Pages I-XVI Introduction....Pages 1-3 Front Matter....Pages 5-5 Can Infarct Size Be Limited? Prospects for “Injury-Delaying” Therapy....Pages 7-15 Factors Determining the Size of an Experimental Infarct....Pages 17-17 The Pathogenesis of Thrombosis in Human Atherosclerotic Coronary Arteries....Pages 19-23 Thrombogenesis and Vascular Occlusion....Pages 25-29 Evaluation of Myocardial Perfusion by Means of Contrast Echocardiography....Pages 31-38 Back Matter....Pages 39-41 Front Matter....Pages 43-43 Estimation of Acute Infarct Size In Vivo....Pages 45-53 Pharmacology of Cardioprotection....Pages 55-64 Calcium Antagonists and Ischaemia: A Critical Evaluation....Pages 65-69 Can Myocardial Infarction Be Prevented or Limited by Nonthrombolytic Drugs?....Pages 71-74 Newer Aspects of Drug Therapy: Free Radical Scavengers....Pages 75-82 Stimulation of Vascular Prostacyclin Formation by Defibrotide: A New Strategy for Treatment of Acute Myocardial Ischaemia....Pages 83-93 Back Matter....Pages 95-99 Front Matter....Pages 101-101 Thrombolytic Therapy: State of the Art....Pages 103-105 Early and Prehospital Thrombolytic Therapy in Acute Myocardial Infarction....Pages 107-129 Status of Thrombolytic Therapy in Acute Myocardial Infarction in France....Pages 131-135 Adjuvant Therapy for Coronary Reperfusion in Evolving Acute Myocardial Infarction....Pages 137-146 Perspectives on Newer Thrombolytic Agents....Pages 147-155 Back Matter....Pages 157-160 Front Matter....Pages 161-161 Is Immediate Angioplasty Required to Restore Coronary Blood Flow at Rest After Recanalisation with Intravenous Recombinant Tissue-type Plasminogen Activator in Patients with Acute Myocardial Infarction?....Pages 163-176 Angioplasty After Thrombolysis: Early and Late Angiographic Results....Pages 177-177 PTCA in Acute Myocardial Infarction....Pages 179-187 Back Matter....Pages 207-209 Front Matter....Pages 161-161 What is the Place of Surgery Soon After Thrombolysis?....Pages 189-197 The Use of Cardiovascular Drugs Following Thrombolysis in Humans....Pages 199-205 Back Matter....Pages 207-209 Front Matter....Pages 211-211 Factors Influencing the Rate of Coronary Artery Occlusion and Reocclusion....Pages 213-221 Which Antithrombotic Therapy Has Proven Most Effective for the Treatment of Deep Arterial Injury, Ruptured Plaque, and Post-thrombolysis?....Pages 223-233 Agents Effective in the Limitation of Myocardial Ischaemic Damage: Present Concepts and Future Possibilities....Pages 235-245 Back Matter....Pages 247-251 Front Matter....Pages 253-253 Therapeutic Strategies for Limitation of Infarct Size....Pages 255-275 Back Matter....Pages 276-279