Leukemia: Report Of The Dahlem Workshop On Leukemia Berlin 1983, November 13-18 (dahlem Workshop Report)

and how the known vertebrate homologues of these genes are expressed normally in differentiation and proliferation pathways as well as abnormal­ ly in well-defined lymphomagenic and other oncogenic pathways. What emerged from this meeting are a better understanding of the evolution of these gene systems themselves and an elucidation of simpler systems open to more rapid genetic and molecular genetic analysis to reveal the normal functions of these genes and their gene products. Thus we sought new answers to several old questions concerning differenti­ ation, proliferation, and neoplastic transformation. We gathered together in an unusual format - that of the unique Dahlem Workshops - not just to reiterate data which has recently emerged but to think about how these findings might lead to new approaches for the understanding and therapy of the leukemias and lymphomas. We deliberately chose experts from several different disciplines, ranging from the clinicians who diag­ nose, describe, and treat these maladies, to the molecular geneticists trying to reduce the analysis of the problem to its simplest variables in the simplest systems possible. Front Matter....Pages i-x Introduction....Pages 1-3 Specificity of Hemopoietic Growth Factors....Pages 5-20 T Cell Proliferation and Differentiation....Pages 21-30 Regulatory Defects in Leukemia: In Vitro Analysis....Pages 31-67 Induction of B Cell Proliferation and Differentiation....Pages 69-82 Lymphoid Tumor Stem Cells and Their Regulation....Pages 83-94 Phenotypic Heterogeneity and the Origins of Lymphoid Malignancy in Man: Biological and Clinical Implications....Pages 95-110 Differentiation of T Lymphocytes....Pages 111-130 Effects of Acute Leukemia Viruses on the Differentiation of Hematopoietic Cells....Pages 131-145 Multiple Mechanisms of Oncogene Activation in Viral and Nonviral Neoplasia....Pages 147-162 Oncogenes of Avian Leukemia Viruses....Pages 163-178 Significance of Chromosome Rearrangements in Leukemia and Lymphoma....Pages 179-202 Tracing Development and Cell Lineages in Human Hemopoietic Neoplasia....Pages 203-222 The Preleukemic State in Virus-induced Leukemia....Pages 223-234 The Receptor-mediated Leukemogenesis Hypothesis: A Model of Retroviral Oncogenesis by Viral Stimulation of Cell-surface Receptors....Pages 235-250 Regulation of Hematopoietic Differentiation and Its Disruption Group Report....Pages 251-262 Problems in Differentiation Pathways and Cellular Targets for Leukemogens Group Report....Pages 263-274 Genes and Viruses Able to Transform Hematopoietic Cells Group Report....Pages 275-294 Evolution of the Leukemic State Group Report....Pages 295-300 Back Matter....Pages 301-318