Leucine-Rich Repeat Kinase 2 (LRRK2) (Advances in Neurobiology Book 14)

This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration. Front Matter....Pages i-xvii Front Matter....Pages 1-1 Leucine-Rich Repeat Kinase (LRRK2) Genetics and Parkinson’s Disease....Pages 3-30 Clinical Features of LRRK2 Carriers with Parkinson’s Disease....Pages 31-48 Front Matter....Pages 49-49 LRRK2 Phosphorylation....Pages 51-70 Understanding the GTPase Activity of LRRK2: Regulation, Function, and Neurotoxicity....Pages 71-88 LRRK2 and Autophagy....Pages 89-105 Molecular Insights and Functional Implication of LRRK2 Dimerization....Pages 107-121 LRRK2 and the Immune System....Pages 123-143 Regulation of LRRK2 by Phosphatases....Pages 145-160 Front Matter....Pages 161-161 Models of LRRK2-Associated Parkinson’s Disease....Pages 163-191 LRRK2 and the “LRRKtosome” at the Crossroads of Programmed Cell Death: Clues from RIP Kinase Relatives....Pages 193-208 Interaction of LRRK2 and α-Synuclein in Parkinson’s Disease....Pages 209-226 Mechanisms of Mutant LRRK2 Neurodegeneration....Pages 227-239 Small-Molecule Inhibitors of LRRK2....Pages 241-264 Back Matter....Pages 265-271