Lessons from Animal Diabetes VI: 75th Anniversary of the Insulin Discovery (Rev.Ser.Advs.Research Diab.Animals (Birkhäuser) Book 6)

Front Matter....Pages i-xiii Expression of glutamic acid decarboxylase (GAD) and its role as an autoantigen in insulin-dependent diabetes....Pages 1-32 Molecular genetics of insulin-dependent diabetes mellitus: Analysis of congenic strains....Pages 33-46 Role of macrophages and cytokines in B-cell death....Pages 47-56 Immunotherapy of insulin-dependent diabetes mellitus: Tolerance after short-term anti—;IL-2 receptor/cyclosporine therapy in BB/OK rats....Pages 57-76 Role of retroviruses in the pathogenesis of diabetes with emphasis on the NOD mouse....Pages 77-82 Occurrence of pretype I diabetes (pre-IDDM) and type II diabetes (NIDDM) in BC1 [(NOD x Mus spretus) F1 x NOD] mice....Pages 83-95 Okamoto model for B-cell damage: Recent advances....Pages 97-111 Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan....Pages 113-122 Role of glucokinase in regulation of insulin secretion: Lessons from transgenic mice....Pages 123-130 Consequences of human IAPP expression in transgenic mice....Pages 131-148 Immunostimulatory versus immunosuppressive roles of IL-10 in IDDM: Analysis with IL-10—Producing transgenic NOD mice....Pages 149-173 Polyol accumulation versus diabetic retinopathy and nephropathy in transgenic mice expressing human aldose reductase....Pages 175-200 Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obesity....Pages 201-224 Spontaneously diabetic rat “OLETF” as a model for NIDDM in humans....Pages 225-236 Glucose and lipid metabolism in the gold thioglucose injected mouse model of diabesity....Pages 237-265 Diabetes in the Chinese hamster....Pages 267-298 Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) rat....Pages 299-315 Role of immune and non-immune aspects of genetics in different expressions of diabetes in db/db mice....Pages 317-332 Inositols—Potential roles in insulin action and in diabetes: Evidence from insulin-resistant nonhuman primates....Pages 333-348 Antidiabetic characteristics of dehydroepiandrosterone in animal and human studies....Pages 349-373 Endoneurial vessel abnormalities in diabetic animal models....Pages 375-393 Dog and rat models of diabetic retinopathy....Pages 395-408 Glucose homeostasis in three interstrains (LA/N-BN/Crl cp/cp; Zuc13M-BN/Crl fa/fa; and Zuc13m-LA/N fa/cp) of genetically obese rats....Pages 409-416 Back Matter....Pages 417-420 Genic constructs. Five articles are devoted to this topic ranging from the B-cell function in transgenic animals to the various effects on diabetes complications. The section on NIDDM, comprising of 10 articles, deals both with new and existing models, their particular widely varying pathogenesis, genetic character istics and complications. The animals reviewed include: spontaneously diabetic OLETF rats, Chinese hamsters, Goto-Kakizaki rats, db/db mice, rhesus monkeys, dogs and an article demonstrating the genetic link between the Zucker fa/fa and corpulent cp/cp obese interstrains. We wish to welcome the new members to our Editorial Board, Dr. Hubert Kolb from Dusseldorf, Dr. Alex Rabinovitch from Edmonton, Dr. Takayoshi Toyota from Sendai and Dr. Soroku Yagihashi from Hirosaki. At the same time we would like to thank Dr. Douglas L. Coleman from Bar Harbor and Dr. George Eisenbarth from Denver for their editorial contribution to the previous LAD Vol umes who have retired from the Editorial Board. With great sadness we have to mention Dr. Otho Michaelis IV from Beltsville, MD who suddenly passed away this year. Otho, or Mike as he was called by friends, made a significant contribution in developing and metabolically defin ing several strains of corpulent cp rats and was extremely helpful in the editor ial work of the LAD series. His contribution will remain in a lasting memory of all researchers of animal diabetes