Latent Herpes Virus Infections in Veterinary Medicine : A Seminar in the CEC Programme of Coordination of Research on Animal Pathology, Held at Tübingen, Federal Republic of Germany, September 21–24, 1982

This seminar referred to latent herpes virus infections in veterinary medicine, with emphasis on the domestic animals. The phenomenon of latency is of particular importance in veterinary medicine because it can jeopardize the successful control and eradication of diseases such as Aujeszky's disease and infectious bovine rhinotracheitis, diseases which are often the cause of great economic losses. For this reason, the Commission of the European Communities (CEC) realized the importance of summarizing the present state of knowledge on latent herpes virus infections in veterinary medicine. A seminar was therefore organized by the Federal Research Institute for Animal Virus Diseases in Ttibingen, Federal Republic of Germany, from September 21 to 23, 1982, as a part of the 'Animal Pathology Programme' of the CEC. The seminar was attended by 50 participants not only from the countries of the CEC, and 38 papers were selected for presentation. In veterinary medicine, more intensive investigations on the latency of animal herpes viruses have only relatively recently been initiated. In contrast, great efforts have been made for many years to elucidate latency in human and primate herpes viruses, and consequently the most considerable advances have been made in this field. Some of the most experienced scientists working on both systems were therefore invited. As a result, this seminar was the first occasion on which scientists from different countries and faculties investigating herpes virus latency had the opportunity to present and exchange their latest results. The. Front Matter....Pages I-X Front Matter....Pages 1-1 Herpes Simplex Virus Type 1 Thymidine Kinase Gene Activity Controls Virus Latency and Neurovirulance in Mice....Pages 3-19 Latency of Herpes Simplex Virus in Tree Shrew; Generation of Intertypic Recombinants of Herpes Simplex Virus in Vivo....Pages 21-31 A Review of HSV Latency in Experimental Animals....Pages 33-39 The Influence of Immunity, Natural Resistance and Virulence on the Persistency of Herpes Simplex Virus Following the Infection of the Non-Injured Mucous Membranes of Mice....Pages 41-50 Differences of HSV2 Strains in Their Efficiency of Establishing Latent Infections in Ganglia of Guinea Pigs....Pages 51-61 Herpes Simplex Virus Types 1 and 2 Genes Affecting Latency in Mouse Footpad and Sensory Ganglia....Pages 63-72 New Results on the Biology of Epstein-Barr-Virus....Pages 75-90 Tree Shrew Herpesvirus: Pathogenicity and Latency....Pages 91-102 Oncogenic Herpesviruses of Non-Human Primates — Persistence of Viral DNA in Transformed Lymphoid Cells....Pages 103-103 Characterization of Herpesvirus Saimiri and Herpesvirus Ateles Induced Proteins....Pages 105-126 Factors Involved in Persistent Murine Cytomegalovirus Infections — A Review....Pages 127-147 Quantitative Analysis of Activated Cytolytic T Lymphocytes Present in Vivo After Infection with the Murine Cytomegalovirus....Pages 149-158 Front Matter....Pages 159-159 DNA of Bovine IPV-Virus (BHV-1, IPV Strain) in the Sacral Ganglia of Latently Infected Calves....Pages 161-161 On the Latency of Infectious Bovine Rhinotracheitis Virus Infection and its Significance, Especially with Regard to the Possibility of Controlling Infection....Pages 163-170 Herpesviruses of Bovidae: The Characterization, Grouping and Role of Different Types, Including Latent Viruses....Pages 171-189 Infectious Bovine Rhinotracheitis Virus Excretion after Vaccination, Challenge and Immunosuppression....Pages 191-209 The Role of Latency in the Epizootiology of Infectious Bovine Rhinotracheitis....Pages 211-227 Biology and Molecular Biology of Latent Bovine Herpes Virus Type 1 (BHV-1)....Pages 229-239 The Establishment of IBR-IPV Virus Latency in Cattle Following the Application of an Inactivated IBR-IPV Vaccine....Pages 241-249 Use of Restriction Analysis for the Study of Bovid Herpesvirus 1 Latency....Pages 251-256 Front Matter....Pages 159-159 Recovery of BHV2 from the Nervous System of Experimentally Infected Calves....Pages 259-267 Caprine Herpesvirus I Infection of Young Lambs....Pages 269-277 Malignant Catarrhal Fever Virus: A Lymphotropic Herpesvirus of Ruminants....Pages 279-305 Studies of Persistent and Latent Equid Herpesvirus 1 and Herpesvirus 3 Infections in the Pirbright Pony Herd....Pages 307-319 Characterization of the Feline Herpesvirus Genome and Molecular Epidemiology of Isolates from Natural Outbreaks and Latent Infections....Pages 321-336 The Epizootiology of Feline Viral Rhinotracheitis with Particular Reference of the Nature and Role of the Carrier State....Pages 337-349 Immunity to Felid Herpesvirus 1....Pages 351-362 Front Matter....Pages 363-363 Latency of Pseudorabies Virus....Pages 365-383 Restriction Endonuclease Patterns of the Genome of Aujeszky’s Disease Virus Isolated from Latently Infected Pigs....Pages 385-386 Pseudorabies Viruses from Clinical Outbreaks and Latent Infections Grouped into Four Major Genome Types....Pages 387-401 The Role of the Carrier Pig in the Epidemiology of Aujeszkys Disease....Pages 403-415 Latency of Virulent Aujeszky’s Disease Virus in Pigs is not Prevented by Passive or Active Immunization....Pages 417-427 Occurence of Pseudorabiesvirus DNA in Latently Infected Pigs....Pages 429-444 Latency of Aujeszky’s Disease Virus (ADV) Following Challenge in Previously Vaccinated Pigs....Pages 445-455 Front Matter....Pages 457-457 Ubiquity and Persistence of Marek’s Disease Virus in Tumoural and Non-Tumorous Explants....Pages 459-468 Experimental Marek’s Disease in Turkeys and the Establishment of Turkey Lymphoid Cell Lines....Pages 469-479 Persistence of Viral DNA in Marek’s Disease Virus-Transformed Lymphoblastoid Cell Lines....Pages 481-488 Latency of Pigeon Herpesvirus 1 (PHV1)....Pages 489-499 Summary....Pages 501-518 Back Matter....Pages 519-522 A Seminar in the CEC Programme of Coordination of Research on Animal Pathology, held at Tübingen, F.R.G., September 21-24, 1982