Laser-Driven Particle Acceleration Towards Radiobiology and Medicine (Biological and Medical Physics, Biomedical Engineering)

This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their application to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols. Front Matter....Pages i-xviii Lasers Offer New Tools to Radiobiology and Radiotherapy....Pages 1-15 Front Matter....Pages 17-17 Laser-Plasma Accelerators Based Ultrafast Radiation Biophysics....Pages 19-50 Cyberknife, Dose Fractioning for Clinical Protocols....Pages 51-65 Radiation Therapy Towards Laser-Driven Particle Beams: An “OMICS” Approach in Radiobiology....Pages 67-98 Radiological Safety in Laser Facilities....Pages 99-132 Front Matter....Pages 133-133 Generation of Multi-GeV Electron Beams and Bio-medical Applications....Pages 135-161 Ionization Induced Electron Injection in Laser Wakefield Acceleration....Pages 163-182 All-Optical X-Ray and γ-Ray Sources from Ultraintense Laser-Matter Interactions....Pages 183-201 Dosimetry of Laser-Driven Electron Beams for Radiobiology and Medicine....Pages 203-218 Front Matter....Pages 219-219 Laser-Driven Ion Accelerators: State of the Art and Applications....Pages 221-247 Biological Responses Triggered by Laser-Driven Ion Beams....Pages 249-269 High Resolution Ion and Electron Beam Radiography with Laser-Driven Clustered Sources....Pages 271-294 Recent Progress in Laser Ion Acceleration....Pages 295-313 Back Matter....Pages 315-320