Kynurenine and serotonin pathways progress in tryptophan research ; [proceedings of the International Study Group for Tryptophan Research, sixth international meeting, held May 9-12, 1989, in Baltimore, Maryland

Front Matter....Pages i-xvii Front Matter....Pages 1-1 Retro-, Intro- and Perspectives of Trypto-Fun....Pages 3-13 Tryptophan and Related Alkaloids....Pages 15-28 Stability of Tryptophan in Peptides Against Oxidation and Irradiation....Pages 29-40 Mass Spectrometric Determinations of Tryptophan and its Metabolites....Pages 41-50 Signal-to-Noise Optimization of HPLC-Fluorometric Systems and their Application to the Analysis of Indoles....Pages 51-61 Brain Indole Metabolism Assessed Using in Vivo Dialysis....Pages 63-80 Sub-Picogram Determination of Serotonin Using HPLC with Electrochemical Detection for Microdialysis Studies of Serotonin Release....Pages 81-89 Front Matter....Pages 91-91 Autoradiographic Measurement of the Rate of Serotonin Synthesis in the Rat Brain....Pages 93-105 Autoradiographic Studies of 5HT 2 Receptors....Pages 107-113 Ambivalence on the Multiplicity of Mammalian Aromatic L-Amino Acid Decarboxylase....Pages 115-125 Interrelationships of DNA Cycles and Melatonin Synthesis....Pages 127-136 Regulation of Melatonin Synthesis in the Ovine Pineal Gland....Pages 137-148 Melatonin Synthesis: Multiplicity of Regulation....Pages 149-158 Front Matter....Pages 159-159 The Role of Tryptophan and Kynurenine Transport in the Catabolism of Tryptophan Through Indoleamine 2,3-Dioxygenase....Pages 161-166 Kynureninase and Kynurenine 3-Hydroxylase in Mammalian Tissues....Pages 167-176 Relationships Between Pteridine Synthesis and Tryptophan Degradation....Pages 177-184 Quinolinic Acid and Kynurenic Acid in the Mammalian Brain....Pages 185-199 Kynurenate Forming Enzymes in Liver, Kidney and Brain....Pages 201-205 Regulation of Pyridine Nucleotide Coenzyme Metabolism....Pages 207-218 Front Matter....Pages 219-219 Serotonin: Its Role and Receptors in Enteric Neurotransmission....Pages 221-230 Front Matter....Pages 219-219 Mechanisms of Serotonergic Affect Control....Pages 231-243 Neuroendocrine Responses to L-Tryptophan as an Index of Brain Serotonin Function: Effect of Weight Loss....Pages 245-254 Melatonin Receptors in the Central Nervous System....Pages 255-265 Melatonin Interaction with the Benzodiazepine-GABA Receptor Complex in the CNS....Pages 267-277 Front Matter....Pages 279-279 Effects of Tryptophan 2,3-Dioxygenase Inhibitors in the Rat....Pages 281-288 Bidirectional Relationships Between Tryptophan and Social Behavior in Vervet Monkeys....Pages 289-298 The Regulation of Brain Kynurenic Acid Content: Focus on Indole-3-Pyruvic Acid....Pages 299-308 Physiological Role of 3-Hydroxykynurenine and Xanthurenic Acid Upon Crustacean Molting....Pages 309-318 Kynurenines in the Regulation of Behavior in Insects....Pages 319-328 Effects of Quinolinic and Kynurenic Acids on Central Neurons....Pages 329-336 Behavioral Abnormalities in Rats after Single Treatment with Quinolinic Acid During Early Ontogenesis....Pages 337-342 Front Matter....Pages 343-343 Tryptophan Nutrition and Metabolism: An Overview....Pages 345-358 Comparison of Tryptophan Metabolism in Vivo and in Isolated Hepatocytes from Vitamin B6 Deficient Mice....Pages 359-368 Effects of the Diet and other Metabolic Phenomena on Brain Tryptophan Uptake and Serotonin Synthesis....Pages 369-376 Effects of Tryptophan and of 5-Hydroxytryptamine Receptor Subtype Agonists on Feeding....Pages 377-388 The Role of Serotonin (5-HT) in Feeding Responses to Amino Acids....Pages 389-404 Front Matter....Pages 405-405 Cardiovascular and Endocrine Properties of L-Tryptophan in Combination with Various Diets....Pages 407-416 Acute Effects of Meals on Brain Tryptophan and Serotonin in Humans....Pages 417-423 Implications of Interferon-Induced Tryptophan Catabolism in Cancer, Autoimmune Diseases and Aids....Pages 425-435 Induction of Indoleamine 2,3-Dioxygenase in Tumor Cells Transplanted into Allogeneic Mouse: Interferon-γ is the Inducer....Pages 437-444 Front Matter....Pages 445-445 Plasma Free 5HT, Plasma 5HIAA and Whole Blood 5HT in the Rat....Pages 447-450 Effects of Clomipramine on Extracellular Serotonin in the Rat Frontal Cortex....Pages 451-454 Tryptophan Metabolism in Senile Cataract Patients Assessed by High-Performance Liquid Chromatography....Pages 455-457 The Effect of Aluminum on Rat Brain and Liver Quinolinic Acid Concentrations....Pages 459-462 Kynurenine and Lipid Metabolism....Pages 463-466 Content of Tryptophan in Human Hair....Pages 467-470 Detection of a New Intermediate Product of Indolealkylamine Metabolism in the Brain....Pages 471-473 The Excretion of N 1 -Methyl-2-Pyridone-5-Carboxylic Acid and Related Compounds in Human Subjects after Oral Administration of Nicotinic Acid, Trigonalline and N 1 -Methyl-2-Pyridone-5-Carboxylic Acid....Pages 475-479 Stable Isotope-Labeled Tryptophan as a Precursor for Studying the Disposition of Quinolinic Acid in Rabbits....Pages 481-484 Evidence for the Preferential Production of 3-Hydroxyanthranilic Acid from Anthranilic Acid in the Rat Brain....Pages 485-488 Chronobiological Effects of L-Tryptophan in Humans: Influence on Melatonin Secretion....Pages 489-491 Circadian Patterns of Salivary Melatonin and Urinary 6-Sulfatoxy-Melatonin before and after A 9 Hour Time-Shift....Pages 493-496 Tryptophan Metabolism in Mice Infected with Schistosoma Mansoni ....Pages 497-500 Inhibition of Tryptophan → Niacin Metabolism by Dietary Leucine and by Leucine and 2-Oxo-isocaproate in vitro....Pages 501-504 Induction of Indoleamine 2,3-Dioxygenase in Human Cells in Vitro....Pages 505-509 Differential Effects of Estradiol and Hydrocortisone on Liver Tryptophan Pyrrolase in Rats of Various Ages....Pages 511-514 Indole-3-Pyruvic Acid as a Direct Precursor of Kynurenic Acid....Pages 515-518 Tryptophan Metabolism in Healthy Subjects: Influence of Pyridoxine after Single or Repeated Administrations....Pages 519-522 On Kynureninase Activity....Pages 523-526 Rat Skin Tryptophan 2,3-Dioxygenase....Pages 527-529 Front Matter....Pages 445-445 Kynurenine 3-Monooxygenase Activity of Rat Brain Mitochondria Determined by High Performance Liquid Chromatography with Electrochemical Detection....Pages 531-534 Indolic and Kynurenine Pathway Metabolites of Tryptophan in Rat Brain: Effect of Precursor Availability on in Vivo Release....Pages 535-539 Kinetic Properties of Human Liver Tryptophan Pyrrolase....Pages 541-545 Interferon Type I and II Antagonism: A Novel Regulatory Mechanism of Indoleamine Dioxygenase Induction in Human Peripheral Blood Monocytes and Peritoneal Macrophages....Pages 547-553 Quinolinic Acid Concentrations are Increased in Cerebrospinal Fluid of Rhesus Macaques (Macaca Mulatta) Naturally Infected with Simian Retrovirus Type....Pages 555-558 Increased L-Tryptophan, 5-Hydroxyindoleacetic Acid, 3-Hydroxykynurenine and Quinolinic Acid Concentrations in Cerebral Cortex Following Systemic Endotoxin Administration....Pages 559-562 Non-Competitive Inhibition of 3-Hydroxyanthranilate-3, 4-Dioxygenase by 4-Chloro-3-Hydroxyanthranilic Acid in Whole Brain of Rat....Pages 563-565 Kynurenine-Pyruvate Aminotransferase in Rat Kidney and Brain....Pages 567-572 Enzymatic Synthesis of Papiliochrome II....Pages 573-577 4-Halo-3-Hydroxyanthranilates are Potent Inhibitors of 3-Hydroxyanthranilate Oxygenase in the Rat Brain in Vitro and in Vivo....Pages 579-582 On the Disposition of De Novo Synthesized Quinolinic Acid in Rat Brain Tissue....Pages 583-586 Brain-Specific Control of Kynurenic Acid Production by Depolarizing Agents....Pages 587-590 Effects of 5-Hydroxytryptophan on Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects....Pages 591-593 The Involvement of Bulbospinal Serotonergic Neurons in the Effect of 5-Hydroxytryptophan on Alpha and Gamma Motoneurons....Pages 595-598 Quinolinic Acid-Induced Decreases in Acetylcholine Release in the Rat Nucleus Basalis Magnocellularis....Pages 599-602 The Role of Transaminations in the Pharmacological Effects of Indole-3-Pyruvic Acid....Pages 603-605 Endocrine Response of Prolactin, Cortisol, and Growth Hormone to Low Dose Intravenous L-Tryptophan in Healthy Subjects During Day and Night....Pages 607-609 Specific Binding of L-Tryptophan to Serum Albumin and its Function in Vivo....Pages 611-614 Effects of L-Tryptophan on the Brainstem Indole and Catecholamine Metabolites in Spontaneously Hypertensive Rats....Pages 615-617 Effects of Tryptophan on the Development of Deoxycorticosterone Acetate (DOCA)-Induced Hypertension in Rats....Pages 619-623 Front Matter....Pages 445-445 Cytotoxicity of 3-Hydroxykynurenine: Implications for CNS Damage in Neonatal Vitamin B-6 Deficiency....Pages 625-629 Pellagra, Mycotoxins and Tryptophan-Niacin Metabolism....Pages 631-636 Levels of Non-Proteic Tryptophan in Milk and Soybean Formulas....Pages 637-640 Characterization of L-Tryptophan Transport into Liver in Suckling Rats....Pages 641-644 Efficiency of Exogenous Quinolinic Acid, A Metabolite of Tryptophan, as a Niacin Precursor in Rats....Pages 645-647 Why does a Difference in Growth Rate between Rats of the Wistar and Sprague Dawley Strains Occur when a Niacin-Free and Tryptophan-Limiting Diet is Fed?....Pages 649-651 Plasma Free 5HT and Platelet 5HT in Depression: Case-Control Studies and the Effect of Antidepressant Therapy....Pages 653-658 Kynurenine and Mesangial-Proliferative Glomerulonephritis....Pages 659-662 Impairment of Kynurenine Metabolism in Cardiovascular Disease....Pages 663-667 Tryptophan and its Metabolites in a Family with Hartnup Disease....Pages 669-674 Effect of Huntington’s and Alzheimer’s Diseases on the Transport of Nicotinic Acid or Nicotinamide Across the Human Blood-Brain Barrier....Pages 675-678 Effects of Profound Insulin-Induced Hypoglycemia on Quinolinic Acid in Hippocampus and Plasma....Pages 679-682 Brain and Cerebrospinal Fluid Quinolinic Acid Concentrations in Patients with Intractable Complex Partial Seizures....Pages 683-686 Cerebrospinal Fluid Quinolinic Acid Concentrations are Increased in Acquired Immune Deficiency Syndrome....Pages 687-690 Production of Quinolinic Acid and Kynurenic Acid by Human Glioma....Pages 691-695 Back Matter....Pages 697-715