Kucers' The Use of Antibiotics Sixth Edition: A Clinical Review of Antibacterial, Antifungal and Antiviral Drugs

'I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!'From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA- Written by a top international editorial team - Extensively updated to include new, existing and emerging drugs - Divided into 4 sections, 258 chapters and presented in 2-volumes - Presented and packaged in 2-volumes plus an e-bookKucers' The Use of Antibiotics is the leading major reference work in this vast andrapidly developing field. More than doubled in length compared to the fifth edition, thesixth edition comprises 3000 pages over 2-volumes in order to cover all new and existingtherapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs,anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title.Compiled by an expanded team of internationally renowned and respected editors, witha vast number of contributors spanning Europe, Africa, Asia, Australia, South America,the US and Canada, the sixth edition adopts a truly global approach. It will remaininvaluable for anyone using antimicrobial agents in their clinical practice and provides ina systematic and concise manner all the information required when treating infectionsrequiring antimicrobial therapy.Now Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: - It provides access to the entire 2-volume print material - It is fully searchable, so you can find the relevant information you need quickly - Live references are linked to PubMed referring you to the latest journal material - Customise the contents - you can highlight sections and make notes - Comments can be shared with colleagues/tutors for discussion, teaching and learning - The text can also be reflowed for ease of reading - Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics Front Cover......Page 1 Kucers' the use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs, Volume 1, 6th Edition......Page 4 Copyright......Page 5 Table of Contents......Page 6 Contributors......Page 10 Foreword to Kucers' "The Use of Antibiotics"......Page 20 Obituary......Page 22 Preface......Page 24 Abbreviations......Page 26 Section I: Antibiotics......Page 28 Part 1: Penicillins and Related Drugs......Page 30 1. Benzylpenicillin (Penicillin G)......Page 32 2. Phenoxypenicillins......Page 86 3. Ampicillin, Amoxicillin and Other Ampicillin-Like Penicillins......Page 92 4. Methicillin......Page 120 5. Isoxazolyl Penicillins: Oxacillin, Cloxacillin, Dicloxacillin and Flucloxacillin......Page 127 6. Nafcillin......Page 142 7. Carbenicillin, Carindacillin, Carfecillin and Ticarcillin......Page 150 8. Mezlocillin, Azlocillin, Apalcillin and Piperacillin......Page 162 9. Mecillinam (Amdinocillin) and Pivmecillinam......Page 179 10. Temocillin......Page 187 Beta-Lactamase Inhibitors and Combinations......Page 192 11. Clavulanic Acid......Page 194 12. Sulbactam......Page 202 13. Tazobactam and Brobactam......Page 207 14. Amoxicillin–Clavulanic Acid (Co-Amoxiclav)......Page 214 15. Ampicillin–Sulbactam......Page 231 16. Ticarcillin–Clavulanic Acid......Page 248 17. Piperacillin–Tazobactam......Page 265 Part 2: Cephalosporins and Related Drugs......Page 282 18. Cephalothin and Cefazolin......Page 284 19. Cephalexin......Page 295 20. Cephadroxil, Cephaloridine, Cephacetrile, Cephapirin, Cephradine, and Other Rarely Used First-Generation Cephalosporins......Page 302 21. Cefaclor, Cefprozil, and Loracarbef......Page 307 22. Cefuroxime......Page 313 23. Cefotiam, Cefuzonam, Cefamandole, Cefonicid and Ceforanide......Page 322 24. Cefoxitin, Cefotetan and Other Cephamycins (Cefmetazole and Flomoxef)......Page 328 25. Cefoperazone and Cefoperazone–Sulbactam......Page 338 26. Cefotaxime......Page 346 27. Ceftriaxone......Page 378 28. Ceftizoxime, Cefdinir, Cefditoren, Cefpodoxime, Ceftibuten, Cefsulodin, and Cefpiramide......Page 417 29. Cefixime......Page 425 30. Ceftazidime......Page 432 31. Cefpirome......Page 449 32. Cefepime......Page 454 33. Ceftaroline......Page 469 34. Ceftobiprole......Page 475 35. Aztreonam......Page 485 Part 3: Carbapenems......Page 496 36. Imipenem......Page 498 37. Meropenem......Page 527 38. Doripenem......Page 541 39. Ertapenem......Page 553 40. Biapenem......Page 569 41. Faropenem......Page 574 42. Panipenem......Page 580 43. Ritipenem......Page 585 44. Sulopenem......Page 589 Part 4: Glycopeptides and Lipopeptides......Page 594 45. Vancomycin......Page 596 46. Teicoplanin......Page 628 47. Daptomycin......Page 648 48. Oritavancin......Page 665 49. Dalbavancin......Page 672 50. Telavancin......Page 681 51. Ramoplanin......Page 688 Part 5: Aminoglycosides......Page 692 52. Kanamycin......Page 694 53. Gentamicin......Page 701 54. Tobramycin......Page 726 55. Amikacin......Page 739 56. Sisomicin and Netilmicin......Page 754 57. Isepamicin......Page 763 58. Neomycin......Page 769 Part 6: Macrolides and Ketolides......Page 776 59. Erythromycin......Page 778 60. Roxithromycin......Page 797 61. Clarithromycin......Page 806 62. Azithromycin......Page 828 63. Josamycin and Rosaramicin......Page 846 64. Telithromycin......Page 852 65. Cethromycin......Page 861 Part 7: Tetracyclines and Related Drugs......Page 868 66. Tetracycline......Page 870 67. Doxycycline......Page 878 68. Minocycline......Page 897 69. Tigecycline......Page 908 Part 8: Other Antibiotics......Page 920 70. Linezolid......Page 922 71. Quinupristin–Dalfopristin......Page 947 72. Pristinamycin......Page 957 73. Fosfomycin......Page 962 74. Fusidic Acid (Fusidate Sodium)......Page 972 75. Polymyxins......Page 982 76. Novobiocin......Page 998 77. Bacitracin and Gramicidin......Page 1002 78. Mupirocin......Page 1007 79. Lincomycin and Clindamycin......Page 1014 80. Chloramphenicol and Thiamphenicol......Page 1035 81. Spectinomycin......Page 1057 Part 9. Anti-Folate Agents and Other Synthetic Antibacterials......Page 1062 82. Sulfonamides......Page 1064 83. Trimethoprim, Co-Trimoxazole (Co-T) and Related Agents......Page 1103 84. Pyrimethamine......Page 1177 85. Dapsone......Page 1191 86. Trimetrexate......Page 1209 87. Iclaprim......Page 1214 88. Nitrofurans: Nitrofurazone, Furazolidone and Nitrofurantoin......Page 1222 89. Methenamine Mandelate and Methenamine Hippurate......Page 1232 Part 10. Nitroimidazoles......Page 1236 90. Metronidazole......Page 1238 91. Tinidazole......Page 1265 Part 11: Quinolones and Fluoroquinolones......Page 1274 92. Nalidixic Acid and Other Older Quinolones......Page 1276 93. Ciprofloxacin......Page 1292 94. Norfloxacin......Page 1374 95. Ofloxacin......Page 1389 96. Levofloxacin......Page 1423 97. Moxifloxacin......Page 1439 98. Gatifloxacin......Page 1456 99. Garenoxacin......Page 1479 100. Gemifloxacin......Page 1493 101. Sitafloxacin......Page 1502 102. Enoxacin......Page 1509 103. Pefloxacin......Page 1517 104. Sparfloxacin......Page 1528 105. Lomefloxacin......Page 1536 106. Rufloxacin......Page 1544 107. Tosufloxacin......Page 1548 108. Fleroxacin......Page 1553 109. Newer, Discontinued Fluoroquinolones: Temafloxacin, Trovafloxacin, Grepafloxacin, and Clinafloxacin......Page 1565 Part 12: Anti-Tuberculous Drugs......Page 1574 110. Isoniazid......Page 1576 111. Ethambutol......Page 1597 112. Pyrazinamide......Page 1608 113. Rifampicin (Rifampin)......Page 1614 114. Rifabutin......Page 1654 115. Rifaximin......Page 1664 116. Rifapentine......Page 1672 117. Streptomycin......Page 1677 118. Para-Aminosalicylic Acid (PAS)......Page 1689 119. Ethionamide and Prothionamide......Page 1693 120. Thiacetazone......Page 1699 121. Capreomycin......Page 1704 122. Cycloserine......Page 1708 123. Viomycin......Page 1714 Kucers' the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic and Antiviral Drugs, Volume 2, 6th Edition......Page 1717 Section II: Anti-Fungal Drugs......Page 1718 Part 1: Polyenes......Page 1719 124. Amphotericin B (AMB): Deoxycholate and Lipid Formulations......Page 1720 125. Nystatin......Page 1755 126. Natamycin (Pimaricin)......Page 1760 Part 2: Echinocandins, Allylamines and Benzylamine Derivatives......Page 1764 127. Echinocandins – Caspofungin, Anidulafungin and Micafungin......Page 1766 128. Terbinafine......Page 1790 129. Butenafine......Page 1799 130. Naftifine......Page 1803 Part 3: Systemic Azoles......Page 1806 131. Ketoconazole......Page 1808 132. Fluconazole......Page 1833 133. Itraconazole......Page 1851 134. Miconazole......Page 1871 135. Voriconazole......Page 1879 136. Posaconazole......Page 1889 137. Ravuconazole......Page 1898 138. Albaconazole......Page 1904 139. Isavuconazole......Page 1909 Part 4: Topical Azoles......Page 1914 140. Bifonazole......Page 1916 141. Butoconazole......Page 1920 142. Clotrimazole......Page 1923 143. Croconazole......Page 1930 144. Eberconazole......Page 1932 145. Econazole......Page 1934 146. Enilconazole......Page 1938 147. Fenticonazole......Page 1939 148. Flutrimazole......Page 1942 149. Isoconazole......Page 1944 150. Lanoconazole......Page 1946 151. Neticonazole......Page 1948 152. Oxiconazole......Page 1950 153. Sertaconazole......Page 1953 154. Sulconazole......Page 1957 155. Terconazole......Page 1960 156. Tioconazole......Page 1963 157. KP-103......Page 1966 Part 5: Topical Agents - Thiocarbamates, Hydroxypridones and Morpholine......Page 1968 158. Tolnaftate......Page 1970 159. Amorolfine......Page 1972 160. Ciclopirox......Page 1976 161. Rilopirox......Page 1980 Part 6: Other Antifungal Agents and New Agents in Development......Page 1982 162. Flucytosine (5-Fluorocytosine; 5-FC)......Page 1984 163. Griseofulvin......Page 1991 164. Haloprogin......Page 1997 165. New Agents in Development – Nikkomycin Z, CAY-1, Sodarins, Butenolides, Enfungumab, Inositol Phosphoceramide Synthase Inhibitors......Page 1999 Section III: Anti-Parasitic Drugs......Page 2012 Part 1: Anti-Malarial Agents......Page 2014 166. Chloroquine......Page 2016 167. Amodiaquine......Page 2030 168. Quinine and Quinidine......Page 2038 169. Mefloquine......Page 2051 170. Halofantrine......Page 2063 171. Lumefantrine......Page 2069 172. Primaquine......Page 2076 173. Piperaquine......Page 2086 174. Tafenoquine......Page 2095 175. Atovaquone......Page 2100 176. Proguanil and Chloroproguanil......Page 2109 177. Artemisinins......Page 2117 Part 2: Agents Active Against Intestinal and Intra-Abdominal Protozoa......Page 2132 178. Iodoquinol and Quinacrine......Page 2134 179. Fumagillin......Page 2137 180. Furazolidone (Furazolidine)......Page 2141 181. Diloxanide Furoate......Page 2148 182. Spiramycin......Page 2152 183. Nitazoxanide......Page 2159 184. Paromomycin......Page 2167 Part 3: Agents Active Against American Trypanosomiasis......Page 2176 185. Benznidazole......Page 2178 186. Nifurtimox......Page 2182 Part 4: Agents Active Against African Trypanosomiasis......Page 2192 187. Suramin......Page 2194 188. Melarsoprol......Page 2204 189. Eflornithine......Page 2216 Part 5: Agents Active Against Leishmania and Other Pathogens......Page 2228 190. Pentamidine......Page 2230 191. Antimonial Agents......Page 2235 192. Miltefosine......Page 2241 Part 6: Agents Active Against Helminths......Page 2252 193. Albendazole......Page 2254 194. Mebendazole......Page 2267 195. Thiabendazole......Page 2273 196. Triclabendazole......Page 2277 197. Ivermectin......Page 2281 198. Diethylcarbamazine (DEC)......Page 2290 199. Pyrantel Pamoate......Page 2299 200. Praziquantel......Page 2303 201. Oxamniquine......Page 2312 202. Metrifonate......Page 2316 203. Niclosamide......Page 2320 Part 7: Agents Active Against Ectoparasites......Page 2324 204. Permethrin......Page 2326 205. Piperonyl Butoxide......Page 2333 206. Lindane......Page 2337 207. Malathion......Page 2345 208. Crotamiton......Page 2352 Section IV: Anti-Viral Drugs......Page 2356 Part 1: Agents Active Against Herpesviruses......Page 2358 209. Aciclovir......Page 2360 210. Valaciclovir......Page 2388 211. Famciclovir and Penciclovir......Page 2397 212. Ganciclovir and Valganciclovir......Page 2405 213. Cidofovir......Page 2430 214. Vidarabine......Page 2456 215. Foscarnet......Page 2460 216. Maribavir......Page 2483 217. Trifluridine (Trifluorothymidine)......Page 2488 218. Idoxuridine......Page 2492 219. Fomivirsen......Page 2497 Part 2: Agents Active Against the Human Immunodeficiency Virus......Page 2502 Inhibitors of Reserve Transcriptase......Page 2504 220. Zidovudine......Page 2506 221. Didanosine......Page 2539 222. Zalcitabine......Page 2560 223. Lamivudine......Page 2572 224. Stavudine......Page 2590 225. Abacavir......Page 2602 226. Emtricitabine......Page 2622 227. Tenofovir......Page 2640 228. Amdoxovir......Page 2654 229. Apricitabine......Page 2663 Non-Nucleoside Reverse TranscriptaseInhibitors (NNRTIs)......Page 2670 230. Nevirapine......Page 2672 231. Efavirenz......Page 2702 232. Delavirdine......Page 2729 233. Etravirine......Page 2738 234. Rilpivirine......Page 2750 Inhibitors of HIV Protease......Page 2756 235. Saquinavir......Page 2758 236. Ritonavir......Page 2786 237. Indinavir......Page 2803 238. Nelfinavir......Page 2815 239. Lopinavir......Page 2824 240. Amprenavir and Fosamprenavir......Page 2836 241. Darunavir......Page 2851 242. Atazanavir......Page 2857 243. Tipranavir......Page 2869 Other Anti-HIV Agents......Page 2886 244. Enfuvirtide......Page 2888 245. Maraviroc......Page 2896 246. Raltegravir and Other HIV Integrase Inhibitors......Page 2904 Part 3: Agents Active Against Hepatitis Viruses......Page 2916 247. Entecavir......Page 2918 248. Adefovir Dipivoxil......Page 2926 249. Telbivudine......Page 2935 250. Torcitabine and Valtorcitabine......Page 2942 251. Clevudine......Page 2945 252. Ribavirin and Viramidine......Page 2950 253. Interferon Alfa......Page 2986 254. Protease and Polymerase Inhibitors for the Treatment of Hepatitis C Virus Infection......Page 3003 Part 4: Agents Active Against Respiratory Viruses......Page 3018 255. Amantadine and Rimantadine......Page 3020 256. Zanamivir and Polymeric Zanamivir Conjugates......Page 3040 257. Oseltamivir......Page 3056 258. Peramivir......Page 3070 'I am unaware of any textbook which provides such comprehensive coverage of the field and doubt that this work will be surpassed in the foreseeable future, if ever!' From the foreword by Robert C. Moellering, Jr., M.D, Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical School, USA Written by a top international editorial team Extensively updated to include new, existing and emerging drugs Divided into 4 sections, 258 chapters and presented in 2-volumes Presented and packaged in 2-volumes plus an e-book Kucers' The Use of Antibiotics is the leading major reference work in this vast and rapidly developing field. More than doubled in length compared to the fifth edition, the sixth edition comprises 3000 pages over 2-volumes in order to cover all new and existing therapies, and emerging drugs not yet fully licensed. Concentrating on the treatment of infectious diseases, the content is divided into 4 sections: antibiotics, anti-fungal drugs,anti-parasitic drugs and anti-viral drugs, and is highly structured for ease of reference.Within each section, each chapter is structured to cover susceptibility, formulations and dosing (adult and paediatric), pharmacokinetics and pharmacodynamics, toxicity and drug distribution, detailed discussion regarding clinical uses, a feature unique to this title. Compiled by an expanded team of internationally renowned and respected editors, with a vast number of contributors spanning Europe, Africa, Asia, Australia, South America, the US and Canada, the sixth edition adopts a truly global approach. It will remain invaluable for anyone using antimicrobial agents in their clinical practice and provides in a systematic and concise manner all the information required when treating infections requiring antimicrobial therapy. Now Kucers' The Use of Antibiotics is available free to purchasers of the books as an electronic version on line or on your desktop: It provides access to the entire 2-volume print material It is fully searchable, so you can find the relevant information you need quickly Live references are linked to PubMed referring you to the latest journal material Customise the contents - you can highlight sections and make notes Comments can be shared with colleagues/tutors for discussion, teaching and learning The text can also be reflowed for ease of reading Text and illustrations copied will be automatically referenced to Kucers' The Use of Antibiotics
Firmly established through previous editions as the leading and most authoritative work in this vast field, providing all the information that the clinician requires when treating infections and diseases that respond to antibiotic therapy