Iutam Symposium On Cellular, Molecular And Tissue Mechanics: Proceedings Of The Iutam Symposium Held At Woods Hole, Mass., Usa, June 18-21, 2008 (iutam Bookseries)

These are the proceedings of an IUTAM Symposium on Cellular, Molecular and Tissue Mechanics, held in the summer of 2008 at Woods Hole, Mass, USA. This groundbreaking meeting brought together mechanicians having an interest in biological systems, with biophysicists and biologists in order to address the mechanical basis of biology at the molecular, cellular and tissue scales. The meeting explored a wealth of phenomena in cell and molecular biology all of which display a breadth of mechanical influences that may seem surprising at first glance to the traditional mechanician. This arena for the application of methods developed in mechanics has not drawn as much attention as more traditional tissue biomechanics. However, biophysicists, and even biologists apply ideas of elasticity and structural mechanics quite widely in studying molecules and cells. Many critical functions of biomolecules and cells are fundamentally mechanical in origin, and the mechanics of many biomolecules demonstrate scaling laws that are non-classical to traditional structural mechanics and elasticity. This compilation of the scientific papers presented at the meeting will prove invaluable to researchers in the mechanics of biology as this field develops in the decades to come and takes its place as an acknowledged and central area in biology. Front Matter....Pages i-ix Front Matter....Pages 1-1 Experimental and Computational Investigation of Viscoelasticity of Native and Engineered Ligament and Tendon....Pages 3-17 A Comparison of a Nonlinear and Quasilinear Viscoelastic Anisotropic Model for Fibrous Tissues....Pages 19-29 Hysteretic Behavior of Ligaments and Tendons: Microstructural Analysis of Damage, Softening and Non-Recoverable Strain....Pages 31-43 On Measuring Stress Distributions in Epithelia....Pages 45-54 A Viscoelastic Anisotropic Model for Soft Collageneous Tissues Based on Distributed Fiber–Matrix Units....Pages 55-65 Front Matter....Pages 68-68 Chemical and Mechanical Micro-Diversity of the Extracellular Matrix....Pages 69-79 Tissue-to-Cellular Deformation Coupling in Cell-Microintegrated Elastomeric Scaffolds....Pages 81-89 Orientational Polarizability and Stress Response of Biological Cells....Pages 91-101 Universal Temporal Response of Fibroblasts Adhering on Cyclically Stretched Substrates....Pages 103-109 Front Matter....Pages 112-112 Elastic and Electrostatic Model for DNA in Rotation–Extension Experiments....Pages 113-122 Shape and Energetics of DNA Plectonemes....Pages 123-138 Front Matter....Pages 140-140 Constitutive Models for the Force-Extension Behavior of Biological Filaments....Pages 141-159 Small Strain Topological Effects of Biopolymer Networks with Rigid Cross-Links....Pages 161-169 Front Matter....Pages 172-172 An Observation on Bell’s Model for Molecular Bond Separation Under Force....Pages 173-180 A Theoretical Study of the Thermodynamics and Kinetics of Focal Adhesion Dynamics....Pages 181-192 Tension-Induced Growth of Focal Adhesions at Cell–Substrate Interface....Pages 193-201 Pattern Formation and Force Generation by Cell Ensembles in a Filamentous Matrix....Pages 203-213 Mechano-Chemical Coupling in Shell Adhesion....Pages 215-225 Catch-to-Slip Bond Transition in Biological Bonds by Entropic and Energetic Elasticity....Pages 227-233 Front Matter....Pages 236-236 Dilation and Hypertrophy: A Cell-Based Continuum Mechanics Approach Towards Ventricular Growth and Remodeling....Pages 237-244 Front Matter....Pages 236-236 A Morpho-Elastic Model of Hyphal Tip Growth in Filamentous Organisms....Pages 245-255 Extracellular Control of Limb Regeneration....Pages 257-266 Front Matter....Pages 268-268 Bone Composite Mechanics Related to Collagen Hydration State....Pages 269-276 Back Matter....Pages 277-285 Annotation These Proceedings reflect the state of current understanding of the role played by mechanics in biological systems at the molecular, cellular and tissue levels. The invited papers will be notable for the expressed viewpoints of biologists, biophysicists and mechanicians. The topics addressed will range from tissue engineering and tissue mechanics, through cell mechanics, down to the mechanics of biomolecules The invited papers in this book reflect the current understanding of the role mechanics play in the biological system at the molecular, cellular and tissue levels. Topics range from tissue engineering and mechanics to mechanics of cells and biomolecules.