Iron-Sulfur Clusters in Chemistry and Biology. Volume 2: Biochemistry, Biosynthesis and Human Diseases 2

This volume on iron-sulfur proteins includes chapters that discuss how microbes, plants, and animals synthesize these complex prosthetic groups, and why it is important to understand the chemistry and biogenesis of iron sulfur proteins. In addition to their vital importance in mitochondrial respiration, numerous iron sulfur proteins are important in maintenance of DNA integrity. Multiple rare human diseases with different clinical presentations are caused by mutations of genes in the iron sulfur cluster biogenesis pathway. Understanding iron sulfur proteins is important for understanding a rapidly expanding group of metabolic pathways important in all kingdoms of life, and for understanding processes ranging from nitrogen fixation to human disease. Mechanisms of FeS cluster interaction with oxygen. Overview of FeS protein synthesis in model organisms. Relationship of FeS proteins role in human diseases and drug discovery. Preface Tracey A. Rouault biography Contents List of contributing authors 1 A retrospective on the discovery of [Fe-S] cluster biosynthetic machineries in Azotobacter vinelandii 2 The ISC system and the different facets of Fe-S biology in bacteria 3 A stress-responsive Fe-S cluster biogenesis system in bacteria – the suf operon of Gammaproteobacteria 4 Sensing the cellular Fe-S cluster demand: a structural, functional, and phylogenetic overview of Escherichia coli IscR 5 Fe-S assembly in Gram-positive bacteria 6 Fe-S cluster assembly and regulation in yeast 7 The role of Fe-S clusters in regulation of yeast iron homeostasis 8 Biogenesis of Fe-S proteins in mammals 9 Delivery of iron-sulfur clusters to recipient proteins: the role of chaperone and cochaperone proteins 10 Iron-sulfur proteins and human diseases 11 Friedreich ataxia 12 Connecting the biosynthesis of the molybdenum cofactor, Fe-S clusters, and tRNA thiolation in humans 13 Iron-sulphur proteins and genome stability 14 Eukaryotic iron-sulfur protein biogenesis and its role in maintaining genomic integrity 15 DNA signaling by iron-sulfur cluster proteins 16 Iron-sulfur cluster assembly in plants 17 Origin and evolution of Fe-S proteins and enzymes Index