Iron Acquisition by the Genus Mycobacterium: History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development (SpringerBriefs in Molecular Science)

Iron Acquisition by the Genus __Mycobacterium__ summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by __M. tuberculosis__ is featured. Because new drugs for __M. tuberculosis__ are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates. Front Matter....Pages i-v Introduction to the Book....Pages 1-2 A History of Iron Metabolism in the Mycobacteria....Pages 3-39 Mycobacterial Iron Acquisition Mechanisms....Pages 41-52 Siderocalin Combats Mycobacterial Infections....Pages 53-64 Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis ....Pages 65-88 Back Matter....Pages 89-92