Ir genes and Ia antigens [recurso electrónico] proceedings of the third Ir Gene Workshop held at Asilomar, California, December 13-16, 1976

Ir Genes and Ia Antigens features papers that were presented at the Third Ir Gene Workshop held in Asilomar, California, December 13-16, 1976. The book is organized into seven parts that correspond to the seven sessions held during the workshop. The first session focused on the definition of the I-E and I-C subregions, and the mapping and cellular expression of complementing Ir genes. The second session included papers on the expression of gene products of the I region. The third session covered two major areas: (1) the biochemical characterization and primary structure of la antigens; and (2) the possible carbohydrate nature of la antigenic determinant. The studies presented in the fourth session focused on the role of I-region gene products in cellular interactions. The fifth session discussed the "recognition" functions controlled by the I region of the major histocompatibility complex (MHC). The sixth session featured papers on la-containing T cell factors. Finally, the seventh session examined the properties of T-cell antigen receptors. Content: Front Matter , Page iii Copyright , Page iv Participants , Pages xi-xvi Preface , Pages xvii-xviii CHAIRMAN'S SUMMARY: SEROLOGY, GENETICS, AND MAPPING OF THE I REGION , Pages 3-7 , Donald C. Shreffler FURTHER SEROLOGICAL AND GENETIC CHARACTERIZATION OF THE I-E and I-C SUBREGIONS , Pages 9-19 , Chella S. David, John F. McCormick, Jack H. Stimpfling EVIDENCE FOR AN I-E SUBREGION , Pages 21-27 , David H. Sachs EVIDENCE FOR THE PRESENCE OF AN Ia MOLECULE DETERMINED BY EACH OF THE Ia-3 and Ia-5 LOCI , Pages 29-35 , T.L. Delovitch, D.B. Murphy, H.O. McDevitt SEROLOGICAL ANALYSIS OF RECOMBINANT STRAIN A.TFR5 , Pages 37-47 , Donal B. Murphy, Patricia P. Jones, Hugh O. McDevitt MAPPING THE Ir-Thy-1 LOCUS TO THE K REGION OF THE H-2 COMPLEX , Pages 49-54 , Marek B. Zaleski, Jan Klein COUPLED COMPLEMENTATION OF Ir GENES , Pages 55-66 , M.E. Dorf, J.H. Stimpfling, N.K. Cheung, B. Benacerraf RESPONSES OF INBRED MICE TO POLY (GLU 60 ALA 30 TYR 10 ), GAT 10 , AND POLY (GLU 55 LYS 37 LEU 8 )--GLLEU 8 - DISCORDANT RESULTS , Pages 67-76 , Paul H. Maurer, Carmen F. Merryman, David Ganfield, Chang-Hai Lai FUNCTIONAL COMPLEMENTATION AND POLYMORPHISM OF H-2 LINKED IMMUNE RESPONSE GENES , Pages 77-86 , INGA MELCHERS, KLAUS RAJEWSKY GENE COMPLEMENTATION IN THE T-LYMPHOCYTE PROLIFERATION ASSAY: AN ANALYSIS OF THE SITES OF EXPRESSION OF THE TWO GENE PRODUCTS , Pages 87-96 , Ronald H. Schwartz, Gustavo Cudkowicz, William E. Paul “INTERACTION” MLR STIMULATING DETERMINANTS EXPRESSED ON F1 CELLS , Pages 97-103 , C.G. Fathman CHAIRMAN'S SUMMARY: SELECTED EXPRESSION OF I REGION GENE PRODUCTS IN FUNCTIONALLY DISTINCT IMMUNOCOMPETENT CELL POPULATIONS , Pages 107-109 , Hugh O. McDevitt EXPRESSION OF Ia ANTIGENS ON T CELL LEUKEMIAS AND THYMOCYTES , Pages 111-120 , C.S. David, B.D. Schwartz, K. Okuda, S.E. Cullen, J. Hilgers, R.H. Schwartz T CELL REACTIVITY of ANTI-Ia SERA , Pages 121-134 , Dietrich Götze EXPRESSION OF AN I REGION LOCUS IN HELPER T LYMPHOCYTES , Pages 135-145 , Ko Okumura, Donal B. Murphy, Leonore A. Herzenberg, Hugh O. McDevitt, Leonard A. Herzenberg TWO LOCI SELECTIVELY EXPRESSED ON FUNCTIONALLY DIFFERENT T CELLS , Pages 147-156 , Ko Okumura, Takeshi Tokuhisa, Toshitada Takemori, Tomio Tada DEMONSTRATION OF T CELL SPECIFIC Ia ANTIGENS CODED FOR BY THE I-J SUBREGION ON IDIOTYPIC SUPPRESSOR T CELLS , Pages 157-162 , G.J. Hämmerling, K. Eichmann EXPRESSION OF Ia ANTIGENS ON MURINE MACROPHAGES , Pages 163-169 , Carol Cowing, Howard B. Dickler SUBPOPULATIONS OF PERITONEAL MACROPHAGES IDENTIFIED WITH ANTI-Ia SERA , Pages 171-174 , Martin E. Dorf, Emil R. Unanue THE FUNCTIONAL EXPRESSION OF Ia ANTIGENS ON T LYMPHOCYTES AND MACROPHAGES IN THE GUINEA PIG , Pages 175-184 , Uki Yamashita, Ethan M. Shevach THE ASSOCIATION BETWEEN Ia ANTIGENS AND Fc RECEPTORS ON MURINE B LYMPHOCYTES IS PROBABLY LIGAND-INDUCED , Pages 185-193 , Howard B. Dickler, Mary T. Kubicek, Robert D. Arbeit, Susan O. Sharrow Ia ANTIGENS ON FcR POSITIVE T LYMPHOCYTES , Pages 195-200 , Bob Stout, Donal Murphy, Hugh McDevitt, Leonard Herzenberg IDENTIFICATION OF SEPARATE I REGION PRODUCTS BY TWO-DIMENSIONAL ELECTROPHORESIS , Pages 203-213 , Patricia P. Jones, Donal B. Murphy, Hugh O. McDevitt THE GUINEA PIG I REGION- A STRUCTURAL, GENETIC AND FUNCTIONAL ANALYSIS , Pages 215-228 , Benjamin D. Sehwartz, Ethan M. Shevach STUDIES OF THE STRUCTURE OF THE HUMAN Ia-LIKE ANTIGEN , Pages 229-234 , Tim Springer, Jim Kaufman, Cox Terhorst, Jack Strominger IMMUNOLOGICAL STUDIES OF HUMAN Ia-LIKE ANTIGENS , Pages 235-241 , Jim Kaufman, Abe Fuks, Marius Giphart, Bjarte Solheim, Jack Strominger EVIDENCE THAT Ia ANTIGENIC SPECIFICITIES ARE DEFINED BY CARBOHYDRATE , Pages 243-253 , C.R. Parish, D.C. Jackson, I.F.C. McKenzie INABILITY TO DETECT Ia ANTIGENS IN MOUSE SERA , Pages 255-261 , Chella S. David, Brian C. Neely, Susan E. Cullen ANTIGENIC STRUCTURE OF THE Ia GLYCOPROTEIN MOLECULES , Pages 263-273 , John H. Freed, Stanley G. Nathenson PARTIAL AMINO ACID SEQUENCE ANALYSES OF Ia MOLECULES , Pages 275-286 , M. Cecka, M. McMillan, L. Hood, D. Murphy, J. Silver, H. McDevitt GENETIC CONTROL OF CELLULAR INTERACTIONS , Pages 289-295 , William E. Paul ANTIGEN PRESENTATION IN THE T-LYMPHOCYTE PROLIFERATION ASSAY: REQUIREMENT FOR GENETIC IDENTITY AT THE MAJOR HISTOCOMPATIBILITY COMPLEX , Pages 297-304 , Ronald H. Schwartz, Akihiko Yano, William E. Paul THE ROLE OF Ia ANTIGENS IN MACROPHAGE-T LYMPHOCYTE INTERACTIONS , Pages 305-314 , David W. Thomas, Ethan M. Shevach IN VITRO RESPONSES UNDER I REGION CONTROL , Pages 315-323 , Marc Feldmann, Sarah Howie, Peter Erb, Paul Maurer, Edna Mozes, Ulrich Hammerling IR-1A GENE INFLUENCE ON CHIMERIC LYMPHOID CELL INTERACTIONS , Pages 325-340 , Joan L. Press, H.O. McDevitt THREE SITUATIONS IN WHICH HELPER T CELLS FAIL TO COLLABORATE WITH H2-NONIDENTICAL B CELLS , Pages 341-350 , J. Sprent THE ROLE OF INHIBITORY T CELLS IN PREVENTING T-B CO-OPERATION BETWEEN HISTOINCOMPATIBLE CELLS , Pages 351-355 , Waldmann H., Pope H., Kenny G., Munro A. H-2 GENE COMPLEX REGULATION OF MACROPHAGE-LYMPHOCYTE INTERACTIONS IN ANTIBODY RESPONSES IN VITRO , Pages 357-366 , Carl W. Pierce, Judith A. Kapp ON THE ROLE OF Ia IN B-T CELL INTERACTION , Pages 367-371 , Claudia Henry, Eva L. Chan, Dankward Kodlin POSSIBLE FUNCTION OF H-2 CODED CELL-SURFACE MARKERS: H-2 STRUCTURES ARE RECEPTORS FOR DIFFERENTIATION SIGNALS , Pages 373-377 , Rolf M. Zinkernagel INVOLVEMENT OF I REGION PRODUCTS IN T-CELL IMMUNITY AGAINST TNP-MODIFIED AUTOLOGOUS CELLS , Pages 379-385 , Anne-Marie Schmitt-Verhulst, Gene M. Shearer SECTION 5: GENES AND IMMUNOCOMPETENT CELL ACTIVATION. NEW I REGION FUNCTIONS CHAIRMAN'S DISCUSSION , Pages 389-391 , Baruj Benacerraf THE REQUIREMENT OF Ia POSITIVE MACROPHAGES IN THE PRIMARY IN-VITRO HUMORAL RESPONSE , Pages 393-404 , John E. Niederhuber, Laura Mayo, Donald C. Shreffler DETERMINANT SELECTION: A MACROPHAGE-MEDIATED IMMUNE RESPONSE GENE FUNCTION , Pages 405-415 , Alan S. Rosenthal, Lanny J. Rosenwasser, Marcello A. Barcinski Ia ANTIGENS ON T AND B LYMPHOCYTE SUBPOPULATIONS , Pages 417-421 , J.A. Frelinger, O. Lukasewycz, S.W. Hill, F. Hibbler H-2 LINKED CONTROL OF THE ANTIBODY AND CELLULAR IMMUNE RESPONSE TO NUCLEASE AT THE LEVEL OF INDIVIDUAL REGIONS OF THE MOLECULE , Pages 423-431 , Jay A. Berzofsky, Ronald H. Schwartz, Alan N. Schechter, David H. Sachs INHIBITORY EFFECT OF ANTI-Ia SERA ON PROLIFERATIVE RESPONSES TO (H,G)-A--L and (Phe,G)-A--L , Pages 433-444 , Peter Lonai, Donal B. Murphy, Hugh O. McDevitt THE PRESENCE OF IA ANTIGENS ON THE SURFACE OF LEUKEMIC CELLS IS ASSOCIATED WITH THE IMMUNOGENICITY OF A TUMOR SPECIFIC TRANSPLANTATION ANTIGEN , Pages 445-454 , Ira Green, Guido Forni, Theodore Konen, Helen Hu, Benjamin D. Schwartz, Anne Kask, Ethan M. H-2 LINKED REGULATION OF CELL-MEDIATED RESPONSIVENESS TO AN AKR TUMOR ASSOCIATED ANTIGEN , Pages 455-467 , Daniel Meruelo, Beverly Deak, Hugh O. McDevitt CHAIRMAN'S SUMMARY: T CELL FACTORS BEARING Ia DETERMINANTS , Pages 471-473 , Jonathan Uhr SOME PROPERTIES AND FUNCTIONS OF ANTIGEN SPECIFIC T CELL FACTORS , Pages 475-485 , Edna Mozes I-REGION PRODUCTS AND CELL INTERACTIONS: CONTRIBUTION OF NON H-2 GENES TO ACCEPTOR AND FACTOR FOR (T,G)-A--L , Pages 487-491 , A. Munro, M. Taussig, J. Archer MAPPING IMMUNE RESPONSE GENES IN MAN USING THE ANTIGEN-SPECIFIC T CELL FACTOR , Pages 493-501 , Michael J. Taussig ROLE OF AN Ia - POSITIVE ALLOGENEIC EFFECT FACTOR IN B CELL ACTIVATION , Pages 503-516 , Terry L. Delovitch SUPPRESSIVE T CELL FACTOR AND ITS ACCEPTOR EXPRESSED ON DIFFERENT SUBSETS OF T CELLS: A POSSIBLE AMPLIFICATION LOOP IN THE SUPPRESSOR SYSTEM , Pages 517-527 , Tomio Tada, Masaru Taniguchi, Takeshi Tokuhisa EXPRESSION OF IR GENES IN T CELLS , Pages 529-537 , Judith A. Kapp, Carl W. Pierce, Jacques Thèze, Baruj Benacerraf PROPERTIES OF THE PURIFIED IMMUNOSUPPRESSIVE FACTOR(S) SPECIFIC FOR L-GLUTAMIC ACID 60 -L-ALANINE 30 -L-TYROSINE 10 , Pages 539-548 , Jacques Thèze, Judith Kapp, Baruj Benacerraf SPECIFIC SUPPRESSOR EXTRACT STIMULATES THE PRODUCTION OF SUPPRESSOR T CELLS , Pages 549-557 , Carl Waltenbaugh, Baruj Benacerraf H-2 AND NON H-2 GENE CONTROL OF T CELL SUPPRESSION OF MLR , Pages 559-565 , SUSAN SOLLIDAY RICH, FRANK M. ORSON, ROBERT R. RICH THE NATURE OF RECEPTORS FOR ANTIGENS ON T-CELLS , Pages 569-570 ATTEMPTS TO EVALUATE THE MOLECULAR BASIS OF THE GENETIC CONTROL OF THE IMMUNE RESPONSE BY ANTISERA DIRECTED AGAINST LYMPHOID CELL MEMBRANE COMPONENTS , Pages 571-582 , A.F. Geczy, Carolyn L. Geczy, A.L. de Weck ANTIGEN RECEPTORS ON MOUSE T LYMPHOCYTES , Pages 583-595 , M. Cramer, U. Krawinkel, G. Hämmerling, S.J. Black, C. Berek, K. Eichmann, K. Rajewsky IDIOTYPIC RECEPTORS ON T LYMPHOCYTES WITH SPECIFICITY FOR FOREIGN MHC ALLOANTIGENS , Pages 597-606 , LEIF ANDERSSON, HANS HINZ, HANS WIGZELL REPORT ON Ia NOMENCLATURE WORKSHOP , Pages 609-613 , D.C. Shreffler, D.B. Murphy