Ion Transport Across Epithelial Tissues and Disease: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 2 (Physiology in Health and Disease)

This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians. Front Matter ....Pages i-xix Organoids as a Model for Intestinal Ion Transport Physiology (Hugo R. de Jonge, Marcel J. C. Bijvelds, Ashlee M. Strubberg, Jinghua Liu, Lane L. Clarke)....Pages 1-39 Secretory Diarrhea (Nadia Ameen, Sascha Kopic, Kaimul Ahsan, Leandra K. Figueroa-Hall)....Pages 41-76 Role of the Epithelium in Diseases of the Intestine (Jörg D. Schulzke, Michael Fromm)....Pages 77-109 Diseases of the Pancreas Involving Channels/Transporters (Brandon M. Blobner, David C. Whitcomb)....Pages 111-141 Fundamentals of Ion Transport Across Human Sweat Gland in Health and Disease (M. M. Reddy)....Pages 143-175 Transporters in the Lactating Mammary Epithelium (Margaret C. Neville, Akihiro Kamikawa, Patricia Webb, Palaniappian Ramanathan)....Pages 177-239 Lipid Transport Across the Mammary Gland (James L. McManaman)....Pages 241-277 Ion Transport Across Inner Ear Epithelia (Daniel C. Marcus)....Pages 279-305 Regulation of Ion Transport Through Retinal Pigment Epithelium: Impact in Retinal Degeneration (Nadine Reichhart, Olaf Strauß)....Pages 307-331 Ion Transport in the Choroid Plexus Epithelium (Laura Øllegaard Johnsen, Helle Hasager Damkier, Jeppe Praetorius)....Pages 333-361 Transport Functions of Ectoderm Epithelial Cells Forming Dental Enamel (Michael L. Paine, Alan Boyde, Rodrigo S. Lacruz)....Pages 363-382