Ion Channels and Transporters of Epithelia in Health and Disease (Physiology in Health and Disease)

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside.℗ℓ The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels Front Matter....Pages i-xiv Front Matter....Pages 1-1 Fundamentals of Epithelial Cl− Transport....Pages 3-47 Fundamentals of Epithelial Na+ Absorption....Pages 49-94 Physiologic Influences of Transepithelial K+ Secretion....Pages 95-130 Volume Regulation in Epithelia....Pages 131-185 Fundamentals of Bicarbonate Secretion in Epithelia....Pages 187-263 Mathematical Modeling of Epithelial Ion Transport....Pages 265-278 Molecular Mechanisms of Apical and Basolateral Sorting in Polarized Epithelial Cells....Pages 279-302 Membrane Protein Folding and Structure....Pages 303-331 Front Matter....Pages 333-333 P2X Receptors in Epithelia....Pages 335-350 Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells....Pages 351-374 Na+-K+-2Cl− Cotransporter....Pages 375-400 Thiazide-Sensitive NaCl Cotransporter....Pages 401-435 NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia....Pages 437-463 Properties and Function of the Solute Carrier 26 Family of Anion Transporters....Pages 465-489 ClC-2 Chloride Channels....Pages 491-518 CFTR and Cystic Fibrosis....Pages 519-552 TMEM16 Proteins (Anoctamins) in Epithelia....Pages 553-567 Epithelial Sodium Channels (ENaCs)....Pages 569-641 ROMK and Bartter Syndrome Type 2....Pages 643-658 KCa3.1 in Epithelia....Pages 659-705 Front Matter....Pages 333-333 BK Channels in Epithelia....Pages 707-723 Orai Channels....Pages 725-745 ADPKD Channels: The Polycystins....Pages 747-771 CFTR and Cystic Fibrosis: A Need for Personalized Medicine....Pages 773-802 Renal Aquaporins in Health and Disease....Pages 803-854 Front Matter....Pages 855-855 Recent Developments in the Pharmacology of Epithelial Ca2+-Activated K+ Channels....Pages 857-899 Small-Molecule Pharmacology of Epithelial Inward Rectifier Potassium Channels....Pages 901-928 Front Matter....Pages 929-929 Diseases of the Pancreas Involving Channels/Transporters....Pages 931-955 Secretory Diarrhea....Pages 957-990 Back Matter....Pages 991-1019 This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside.℗l The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels