INTRODUCTION TO THE CELLULAR AND MOLECULAR BIOLOGY OF CANCER; ED. BY MARGARET KNOWLES

This new edition o Introduction and Molecular Biology of Cancer provides a concise yet comprehensive overview of cancer biology, covering the current status of both research and treatment. For the student or new researcher the breadth of cancer research can appear daunting, yet a broad understanding is essential for translation of laboratory findings into the clinic. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field, and the accompanying bibliographies allow rapid access to the relevant current literature. The book covers topics extending from the molecular alterations found in cancer cells and their causes to the current range of approaches to treatment. Since the publication of the previous edition in 1997 there has been unprecedented progress in cancer research: this is reflected by an extensive revision of all the material, and the addition of eight new chapters, covering DNA repair, epigenetic events, the cell cycle, cell immortalization, apoptosis, angiogenesis, animal models, the genome, transcriptome and proteome, radiotherapy and molecular radiotherapy, immunotherapy, and gene therapy. The fourth edition of the popular book will serve as a text for both undergraduate and postgraduate use and also as an introduction for clinicians and scientists new to the field. Ruth O'Regan This book is truly what its title says it is -- a highly comprehensive, up-to-date guide to the molecular basis of carcinogenesis. It is divided into concise chapters that direct the reader through the world of cancer, from the very basics to up-to-date descriptions of signal transduction pathways. Additionally, a number of chapters describe treatments for cancer, including current immunological and monoclonal antibody-based therapies. The book was written for students, clinicians, and scientists new to the field of molecular carcinogenesis. I feel that this book truly meets these expectations and in many cases provides extra knowledge. Each chapter is written by experts in the field. The book is well illustrated with many helpful, easy to follow figures and tables. The references are appropriate and up-to-date. Additionally, this book has a very extensive glossary of terms commonly used in cancer and molecular carcinogenesis. I feel the third edition of this book is entirely necessary (the previous edition was published in 1990) as the fields of molecular biology of cancer and cancer treatments are continuously evolving and it is essential that anyone new to these fields has access to the most current concepts. I would definitely recommend this book to anyone starting out in the fields of oncology and cancer research. Contents......Page 13 Contributors......Page 17 1 What is cancer?......Page 21 2 The causes of cancer......Page 45 3 Inherited susceptibility to cancer......Page 65 4 DNA repair and cancer......Page 81 5 Epigenetic events in cancer......Page 98 6 Molecular cytogenetics of cancer......Page 115 7 Oncogenes......Page 137 8 Tumour suppressor genes......Page 155 9 The cancer cell cycle......Page 176 10 Cellular immortalization and telomerase activation in cancer......Page 190 11 Growth factors and their signalling pathways in cancer......Page 206 12 Apoptosis: molecular physiology and significance for cancer therapeutics......Page 230 13 Mechanisms of viral carcinogenesis......Page 249 14 Cytokines and cancer......Page 262 15 Hormones and cancer......Page 277 16 The spread of tumours......Page 298 17 Tumour angiogenesis......Page 309 18 Stem cells, haemopoiesis, and leukaemia......Page 325 19 Animal models of cancer......Page 337 20 The immunology of cancer......Page 357 21 The molecular pathology of cancer......Page 376 22 From transcriptome to proteome......Page 389 23 Local treatment of cancer......Page 410 24 Chemotherapy......Page 419 25 Radiotherapy and molecular radiotherapy......Page 434 26 Monoclonal antibodies and therapy......Page 448 27 Immunotherapy of cancer......Page 463 28 Cancer gene therapy......Page 478 29 Screening......Page 500 30 Conclusions and prospects......Page 523 A......Page 526 B......Page 528 C......Page 529 D......Page 532 E......Page 534 G......Page 535 H......Page 536 I......Page 538 L......Page 539 M......Page 541 O......Page 543 P......Page 544 R......Page 546 S......Page 548 T......Page 549 V......Page 551 Z......Page 552 This new edition of Introduction to the Cellular and Molecular Biology of Cancer provides a comprehensive overview of cancer biology, covering the current status of both research and treatment. For the student or new researcher the breadth of cancer research can appear daunting, yet a broad understanding is essential for translation of laboratory findings into the clinic. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field, and the accompanying bibliographies allow rapid access to the relevant current literature. The book covers topics extending from the molecular alterations found in cancer cells and their causes to the current range of approaches to treatment. Since the publication of the previous edition in 1997 there has been unprecedented progress in cancer research: this is reflected by an extensive revision of all the material, and the addition of eight new chapters, covering DNA repair, epigenetic events, the cell cycle, cell immortalisation, apoptosis, angiogenesis, animal models, the genome, transcriptome and proteome, radiotherapy and molecular radiotherapy, immunotherapy, and gene therapy. The fourth edition of this popular book will serve as a text for both undergraduate and postgraduate use and also as an introduction for clinicians and scientists new to the field. . What is cancer?, L.M. Franks and Margaret A. Knowles. 2. The causes of cancer, Naomi Allen, Robert Newton, Amy Berrington de Gonzalez, Jane Green, Emily Banks, and Timothy J. Key. 3. Inherited Susceptibility to Cancer, D. Timothy Bishop. 4. DNA Repair and Cancer, Beate Koberle, John P. Wittschieben, and Richard D. Wood. 5. Epigenetic Events in Cancer, Jonathan C. Cheng and Peter A. Jones. 6. Molecular Cytogenetics of Cancer, Denise. Sheer and Janet Shipley. 7. Oncogenes, Margaret A. Knowles. 8. Tumour suppressor genes, Sonia Lain and David P. Lane. 9. The cancer cell cycle, Chris J. Norbury. Aimed at both students and new researchers, the fourth edition of this text provides a concise yet comprehensive overview of cancer biology, covering the current status of both research and treatment