Introduction to biological and small molecule drug research and development [recurso electrónico] : Theory and case studies

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry. For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development Content: Front Matter , Page iii Copyright , Page iv Biographies , Pages xiii-xvii Preface , Pages xix-xx , C. Robin Ganellin, Roy Jefferis, Stanley M. Roberts Chapter 1 - Introduction to enzymes, receptors and the action of small molecule drugs , Pages 1-55 , Stanley M. Roberts, Alasdair J. Gibb Chapter 2 - Protein structure and function , Pages 57-79 , Jennifer Ann Littlechild Chapter 3 - The small molecule drug discovery process – from target selection to candidate selection , Pages 81-126 , Michael Stocks Chapter 4 - Protein therapeutics (introduction to biopharmaceuticals) , Pages 127-159 , Jill M. Carton, William R. Strohl Chapter 5 - Similarities and differences in the discovery and use of biopharmaceuticals and small-molecule chemotherapeutics , Pages 161-203 , James Samanen Chapter 6 - Therapies for type 2 diabetes: modulating the incretin pathway using small molecule peptidase inhibitors or peptide mimetics , Pages 205-223 , Matthew P. Coghlan, David Fairman Chapter 7 - The structure and business of biopharmaceutical companies including the management of risks and resources , Pages 225-253 , James Samanen Chapter 8 - Discovery and development of the anticancer agent gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase , Pages 255-281 , Andy Barker, David Andrews Chapter 9 - Targeting HER2 by monoclonal antibodies for cancer therapy , Pages 283-305 , Hasmann Chapter 10 - Recombinant human erythropoietin and its analogues , Pages 307-326 , Wolfgang Jelkmann Chapter 11 - Lysosomal storage disorders: current treatments and future directions , Pages 327-341 , Charles W. Richard III Chapter 12 - Hormone replacement therapy , Pages 343-353 , Stanley M. Roberts Chapter 13 - Design of the anti-HIV protease inhibitor darunavir , Pages 355-384 , Arun K. Ghosh, Bruno D. Chapsal Chapter 14 - The case of anti-TNF agents , Pages 385-397 , Denis Mulleman, Marc Ohresser, Hervé Watier Chapter 15 - Discovery of the cholesterol absorption inhibitor, ezetimibe , Pages 399-416 , C. Robin Ganellin Colour Plate , Pages 1-21 Index , Pages 417-425

Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more.

Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry.

• For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level
• Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs
• Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

The fundamental concept of the book is to provide, for the first time, an introduction to understand the science behind successful pharmaceutical research and development programs. As well as explaining the basic principles, the book compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs and presents an overview of the business and management issues for these approaches. The second part of the book provides 9 carefully selected real life case studies to illustrate how the theory presented in the first part of the book is actually being put into practice. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine or allied subjects. The book would be used as part of the reading matter for a wide variety of science degree courses, in post-graduate taught material (Masters and PhD) and as basic background reading for scientists in the pharmaceutical industry. . For the first time the fundamental principles of the science of biopharmaceutics and small molecule chemotherapeutics are discussed side-by-side at a basic level . Edited by three senior scientists with over 100 years experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs . The book will be of broad interest to students of medicine, pharmacy, biochemistry and chemistry who wish to learn about drug discovery . Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development Provides an introduction to understand the science behind successful pharmaceutical research and development programs. Explaining the basic principles, this book compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs and presents an overview of the business and management issues for these approaches.