intratubular Germ Cell Neoplasms of The Testis and Bilateral Testicular Tumors Clinical Significance and Management Options

The book aims to provide an overview of current knowledge regarding germ cell tumors. It deals with the clinical presentations, treatment modalities, the biology and genetics of germ cell tumors in children and adults. Most chapters are focused on testicular germ cell tumors whose incidence has been increasing in young males. Included are reviews on the pathogenesis, risk factors, diagnosis and treatment regimens applied to precursor, pre-invasive lesions as well as to seminomatous and non-seminomatous germ cell tumors of the testes. In addition, a review is included on the diagnosis and current management options for intracranial germ cell tumors in children. Authors have also contributed articles on the genetics and epigenetics of germ cell tumor development in humans and in the mouse model system. This book will be of interest to scientists, physicians and lay readers wishing to review recent developments in the field of germ cell cancers Cover......Page 1 Germ Cell Tumor......Page 2 ©......Page 3 Contents......Page 5 Preface......Page 7 Part 1 Clinical Perspectives......Page 10 1 Intratubular Germ Cell Neoplasms of the Testis and Bilateral Testicular Tumors: Clinical Significance and Management Options......Page 12 2 Management of Nonseminomatous Germ Cell Tumor of the Testis......Page 32 3 Diagnostic Imaging of Intracranial Germ Cell Tumors: A Review......Page 56 4 Testicular Germ Cell Tumours - A European and UK Perspective......Page 68 Part 2 Scientific Perspectives......Page 82 5 Mouse Models of Testicular Germ Cell Tumors......Page 84 6 Epigenetic Modifications in Testicular Germ Cell Tumors......Page 116 7 Claudins and Germ Cell Tumors......Page 144