Interventions for Persisting Ductus Arteriosus in the Preterm Infant: Edited by Michael Obladen, Petra Koehne

Over the past few years a remarkably rapid evolution in the professional level of neonatology and in the survival of immature infants has been witnessed. Persisting ductus arteriosus is common in this population and is associated with impaired longterm outcome. Many uncertainties exist concerning indication, approach, best time, and side effects of necessary measurements and interventions to avoid later neurodevelopmental handicaps of the survivors. Experts in neonatology and pediatric cardiology give their opinion in this book. We are sure it will help to define the level of evidence and to develop standards of intervention for persisting ductus arteriosus in Europe. Adequate dealing with the ductus will become a challenge for every perinatal center. Cover ......Page 1 Preface......Page 5 Table of Contents......Page 6 1 Developmental Anatomy of the Ductus Arteriosus......Page 12 2 Regulation of Smooth Muscle Contraction......Page 16 3 Prostaglandin Metabolism and Effects of Inhibitors......Page 22 4 Postnatal Circulatory Adaptation......Page 25 5 Epidemiology of Persisting Ductus in Preterm Infants......Page 29 6 Persisting Ductus Arteriosus and Respiratory Problems......Page 35 7 Influence on Mesenteric Perfusion and Necrotizing Enterocolitis......Page 40 8 Persisting Ductus Arteriosus and Intraventricular Hemorrhage......Page 44 9 Echocardiographic Assessment......Page 49 10 Cerebral Doppler Sonographic Measurements......Page 54 11 Therapeutic Options......Page 60 12 Surgical Closure......Page 65 13 Comparison of Indomethacin and Ibuprofen......Page 73 14 Indomethacin Effects and Side Effects......Page 77 15 Complications of Cyclooxygenase Inhibition in Preterm Infants......Page 82 16 Ibuprofen in Infants Below 28 Gestational Weeks......Page 92 17 Intravenous Ibuprofen - State of Registration......Page 100 18 Summary and Perspectives......Page 102 Subject Index......Page 106 Adequate dealing with the ductus arteriosus will become a challenge for every perinatal center. This book helps to define the level of evidence and to develop standards of intervention for persisting ductus arteriosus in Europe. The ductus arteriosus is a unique, dynamic vascular structure functioning as a prenatal bypass between pulmonary artery and aorta. M. Obladen (editor), P. Koehne (editor). Includes Bibliographical References And Index.