International Textbook of Diabetes Mellitus, 2 Volume Set

The International Textbook of Diabetes Mellitus has been a successful, well-respected medical textbook for almost 20 years, over 3 editions. Encyclopaedic and international in scope, the textbook covers all aspects of diabetes ensuring a truly multidisciplinary and global approach. Sections covered include epidemiology, diagnosis, pathogenesis, management and complications of diabetes and public health issues worldwide. It incorporates a vast amount of new data regarding the scientific understanding and clinical management of this disease, with each new edition always reflecting the substantial advances in the field. Whereas other diabetes textbooks are primarily clinical with less focus on the basic science behind diabetes, ITDM's primary philosophy has always been to comprehensively cover the basic science of metabolism, linking this closely to the pathophysiology and clinical aspects of the disease. Edited by four world-famous diabetes specialists, the book is divided into 13 sections, each section edited by a section editor of major international prominence. As well as covering all aspects of diabetes, from epidemiology and pathophysiology to the management of the condition and the complications that arise, this fourth edition also includes two new sections on NAFLD, NASH and non-traditional associations with diabetes, and clinical trial evidence in diabetes. This fourth edition of an internationally recognised textbook will once again provide all those involved in diabetes research and development, as well as diabetes specialists with the most comprehensive scientific reference book on diabetes available. The International Textbook Of Diabetes Mellitus Has Been A Successful, Well-respected Medical Textbook For Almost 20 Years, Over 3 Editions. Encyclopaedic And International In Scope, The Textbook Covers All Aspects Of Diabetes Ensuring A Truly Multidisciplinary And Global Approach. Sections Covered Include Epidemiology, Diagnosis, Pathogenesis, Management And Complications Of Diabetes And Public Health Issues Worldwide. Title Page; Section Editors; Copyright; Table Of Contents; Contributors; Preface; Section I: Epidemiology; Chapter 1: Classification Of Diabetes Mellitus And Other Categories Of Glucose Intolerance; Introduction; Historical Perspective And Current Classifications; Type 1 Process; Type 2 Process; Other Specific Types; Classification Of Genetic Disorders; Diabetes In Children And Youth; Diagnosis Of Diabetes Using Hba1c; Diagnosis Of Gestational Diabetes Mellitus Impaired Glucose Regulation (impaired Glucose Tolerance And Impaired Fasting Glycemia)normoglycemia; Summary; References; Chapter 2: Epidemiology And Risk Factors For Type 1 Diabetes Mellitus; Introduction; Prevalence And Incidence; Î2-cell Autoimmunity And Risk Factors; Established Type 1 Diabetes; References; Chapter 3: Epidemiology And Geography Of Type 2 Diabetes Mellitus; Age- And Sex-specific Prevalence Of Type 2 Diabetes In Different Ethnic Groups Prevalence Of Impaired Glucose Tolerance And Impaired Fasting Glycemia In Different Ethnic Groupssex Differences In Prevalence Of Diabetes, Igt, And Ifg; The Ratio Of Igt To Diabetes; Secular Trends In Prevalence Of Type 2 Diabetes; Type 2 Diabetes In Children; Modifiable Risk Factors For Type 2 Diabetes; Nontraditional Modifiable Risk Factors For Type 2 Diabetes; References; Section Ii: Physiology Of Pancreatic Function; Chapter 4: Development And Maintenance Of The Islet Î2 Cell; Introduction; Pancreas Development Cytodifferentiation In The Developing Pancreaspostnatal Î2-cell Growth And Maintenance; Conclusions And Areas Of Future Study; References; Chapter 5: Pancreatic Morphology In Normal And Diabetic States; Pancreatic Anatomy And Morphology; Islet Composition And Morphology; Islet Î2 Cell Regenerative Potential; Disturbances In Pancreas/islet Morphology In Diabetes; Mechanisms Of Î2-cell Loss In Type 2 Diabetes; Summary And Future Directions; Acknowledgments; References; Chapter 6: Insulin Gene Expression And Biosynthesis; Introduction Insulin Gene Expressioninsulin Biosynthesis; Acknowledgments; References; Chapter 7: Î2-cell Biology Of Insulin Secretion; Introduction; Î2-cell Metabolism; Metabolism-secretion Coupling; Dynamics Of Insulin Secretion; Modulation Of Insulin Secretion By Various Intracellular Signals; Pathophysiology Of Pancreatic Î2 Cells; Conclusions; References; Chapter 8: Normal Î2-cell Function; Introduction; Methods For The Assessment Of Insulin Secretion; Î2-cell Response To Intravenous Glucose; Î2-cell Response To Oral Glucose Edited By Ralph A. Defronzo, Ele Ferrannini, K. George M.m. Alberti, Paul Zimmet. Includes Bibliographical References And Index.