International Symposium on Nicotine: The Effects of Nicotine on Biological Systems II : Satellite Symposium of the XIIth International Congress of Pharmacology, Montreal, Canada, July 21–24, 1994. The Abstracts

The publisher and editors cannot assume any legal responsibility for information on drug dosage and administration contained in this publication. The respective user must check its accuracy by consulting other sources of reference in each individual case. The use of registered names, trademarks, etc. in this publication, even if not identified as such, does not imply that they are exempt from the relevant protective laws and regulations or free for general use. Alcohol In Human History / B.l. Vallee -- Reward And Its Control By Dynorphin Peptides / L. Terenius -- Adaptation Of Signal Transduction In Brain / C. Alling, L. Gustavsson, C. Larsson, C. Lundqvist, D. Rodriguez And P. Simonsson -- Protein Kinase C And Adaptation To Ethanol / R. Roivainen, B. Hundle And R.o. Messing -- Molecular Control Of Neuronal Survival In The Chick Embryo / S. Biffo, G. Dechant, H. Okazawa And Y.-a. Barde -- Effects Of Alcohol On Gene Expression In Neural Cells / N. Wilke, M. Sganga, S. Barhite And M.f. Miles -- The Role Of The Nmda Receptor In Ethanol Withdrawal / P.l. Hoffman And B. Tabakoff -- Molecular Diversity Of Glutamate Receptors And Their Physiological Functions / S. Nakanishi, M. Masu, Y. Bessho, Y. Nakajima, Y. Hayashi And R. Shigemoto -- Multiple Dopamine Receptors: The D[subscript 3] Receptor And Actions Of Substances Of Abuse / J.-c. Schwartz, J. Diaz, N. Griffon, D. Levesque, M.-p. Martres And P. Sokoloff. Molecular Pharmacology Of Serotonin Receptors / P.r. Hartig -- Alcohol, The Reward System And Dependence / G.f. Koob, S. Rassnick, S. Heinrichs And F. Weiss -- Clinical Aspects On Molecular Probes, Markers And Metabolism / U. Rydberg -- Familial Alcoholism: Family, Twin Adoption And High Risk Studies / J. Knop -- Association Strategies In Substance Abuse / G.r. Uhl -- Pet-determination Of Benzodiazepine Receptor Binding In Studies On Alcoholism / L. Farde, S. Pauli, J.-e. Litton, C. Halldin, J. Neiman And G. Sedvall -- Serotonin, Violent Behavior And Alcohol / M. Linnoila, M. Virkkunen, T. George, M. Eckardt, J.d. Higley, D. Nielsen And D. Goldman -- Neuropeptides And Alcohol Addiction In Monkeys / J.m. Van Ree, M. Kornet And C. Goosen -- The Role Of Adenosine In Mediating Cellular And Molecular Responses To Ethanol / I. Diamond And A.s. Gordon -- Helicobacter Pylori Alcohol Dehydrogenase / M. Salaspuro. Genetic Polymorphism Of Cytochrome P450. Functional Consequences And Possible Relationship To Disease And Alcohol Toxicity / M. Ingelman-sundberg, I. Johansson, I. Persson, M. Oscarson, Y. Hu, L. Bertilsson, M.-l. Dahl And F. Sjoqvist -- Serotonin-altering Medications And Desire, Consumption And Effects Of Alcohol-treatment Implications / C.a. Naranjo And K.e. Bremner -- The Alcohol Dehydrogenase System / H. Jornvall -- Drug Metabolism And Signal Transduction: Possible Role Of Ah Receptor And Arachidonic Acid Cascade In Protection From Ethanol Toxicity / D.w. Nebert -- Recruitment Of Enzymes And Stress Proteins As Lens Crystallins / J. Piatigorsky, M. Kantorow, R. Gopal-srivastava And S.i. Tomarev -- X-ray Structure Of Pqq-dependent Methanol Dehydrogenase / M. Ghosh, A. Avezoux, C. Anthony, K. Harlos And C.c.f. Blake -- Nmr, Alcohols, Protein Solvation And Protein Denaturation / K. Wuthrich. Crystallographic Investigations Of Alcohol Dehydrogenases / H. Eklund, S. Ramaswamy, B.v. Plapp, M. El-ahmad, O. Danielsson, J.-o. Hoog And H. Jornvall -- Retinoids And The Alcohol Dehydrogenase Gene Family / G. Duester -- Alcohol And Acetaldehyde Dehydrogenase Gene Polymorphism And Alcoholism / D.i.n. Sherman, R.j. Ward, A. Yoshida And T.j. Peters -- Site-directed Mutagenesis And Enzyme Properties Of Mammalian Alcohol Dehydrogenases Correlated With Their Tissue Distribution / J.-o. Hoog, M. Estonius And O. Danielsson -- Control Of Alcohol Metabolism / B.v. Plapp -- Angiotensin Converting Enzyme Inhibitors And Alcohol Abuse / J.f. Riordan -- Treatment Of Alcoholism / B. Jansson -- Alcohol Sensitivity And Dependence / M.a. Schuckit -- Treatment Of Alcoholism As A Chronic Disorder / C.p. O'brien -- Addiction And The Potential For Therapeutic Drug Development / P.a.j. Janssen. Therapeutic Lessons From Traditional Oriental Medicine To Contemporary Occidental Pharmacology / W.-m. Keung And B.l. Vallee -- Potential Gene Therapy For Alcoholism / R.o. Brady -- Outlook: Prospects For Alcoholism Treatment / E. Gordis. Edited By B. Jansson ... [et Al.]. Includes Bibliographical References And Index. Front Matter....Pages N2-iii Front Matter....Pages 1-1 Overview....Pages 3-3 Structure and function of nicotinic receptors....Pages 4-5 Nicotinic receptor regulation and tolerance....Pages 6-7 Neuronal, trophic and endocrine effects of nicotine....Pages 8-10 Nicotine and smoking: Current controversies....Pages 11-15 Nicotine and human diseases....Pages 16-18 Front Matter....Pages 19-19 Receptor localization....Pages 21-22 Receptor subtypes — Molecular biology and pharmacology....Pages 23-26 Novel nicotinic receptor ligands....Pages 27-28 ABT — 418, a Novel Nicotinic Agonist....Pages 29-31 Epibatidine, a novel nicotinic receptor agonist....Pages 32-33 Receptor regulation....Pages 34-39 Effects on gene expression....Pages 39-41 Effects on transmitter release and ion fluxes....Pages 42-45 Electrophysiological effects....Pages 46-48 Cardiovascular, autonomic and immune effects....Pages 48-53 Cognitive effects in animals and man....Pages 53-57 Nicotine psychopharmacology in animals....Pages 57-60 Nicotine psychopharmacology in man....Pages 61-65 Pharmacokinetics and pharmacology of metabolites....Pages 66-70 Back Matter....Pages 71-79 The chapters in this volume consider subjects ranging from genetics, markers, and molecular biology of alcoholism, to clinical observations and treatment. The aim is to integrate pertinent information from the fields of molecular and cell biology with clinical and pharmacological knowledge in the attempt to establish molecular bases of alcohol use and abuse. An introductory section summarizes historical aspects of alcohol use, and subsequent chapters concern novel drugs, pharmacological aspects, gene structures, cloning, and enzymatic properties. Several "non-traditional" alcohol scientists number among the authors; their contributions highlight parallels and the possibility of interaction between different fields. Novel results of particular interest include up-dated summaries on receptors, enzymes, and other proteins, as well as corresponding gene structures and regulation, setting the basis for distinguishing markers and pinpointing further possible pharmacological treatments The 39 chapters in this volume consider subjects ranging from genetics, markers, and molecular biology of alcoholism, to clinical observations and treatment. The aim is to integrate pertinent information from the fields of molecular and cell biology with view to establishing a molecular basis of alcohol use and abuse. An initial preview summarizes historical aspects of alcohol use, and subsequent chapters concern novel drugs, pharmacological aspects, gene structures, cloning, and enzymatic properties. Also contributions by'non-traditional'alcohol scientists have been included in this collection, in order to highlight possible interaction and parallels between different fields. Novel results of particular interest include up-dated summaries on receptors, enzymes, and other proteins, as well as corresponding gene structures and regulation, setting the basis for distinguishing markers and pinpointing further possible pharmacological treatments. This collection of abstractions contains, in condensed form, research results in the field of nicotine research presented at the satellite symposium of the 12th International Congress of Pharmacology held in Montreal in July 1994.