International Review of Experimental Pathology: Cytokine-Induced Pathology, Part B: Inflammatory Cytokines, Receptors, and Disease (International Review of Experimental Pathology)

This two-volume set is a comprehensive review of the ''in vivo'' effects in experimental animals induced by several members of the cytokine family. The volumes explain the pharmacological and toxico-pathological effect of such hematopoietic growth factors as colony stimulating factor, the novel factors IL-11 and stem cell factors. Then it summarizes the broad spectrum of activity of several immunostimulatory assays (interleukins IL-1-IL-9) in conventional toxicological assays as well as results from transgenic models. The set also features the inflammatory cytokines (IL-1, TNFa and beta, interfereon-g and TGF-beta) competently reviewed by experts in the field. The set reviews the structure and distribution of the membrane receptors for these growth factors. It addresses the role of various cytokines in disease processes (malaria, sepsis, and meningitis). Volumes 34A and 34B also cover the clinical experience with two growth factors (interferons and GM-CSF), which clearly show that the preclinical data were predictive and valuable for the clinician. Each volume of ''International Review of Experimental Pathology'' contains an index, and each chapter includes references Content: Part 1 Pathology induced by inflammatory cytokines: introduction, B. Ryffel pathophysiologic alterations induced by tumour necrosis factor, D.F. Remick and S.L. Kunkel "in vitro" and "in vivo" activity and pathophysiology of human interleukin-8 and related peptides, R. Zwahlen, et al pathology of recombinant human transforming growth factor-B1 (rhTGF-B1) in rats and rabbits, T.G. Terrell, et al pathology of recombinant murine interferon-g in mice and recombinant human interferon-g in cynomolgus monkeys, T.G. Terrell and J.D. Green. Part 2 Cytokine receptors: introduction, B. Ryffel pharmacokinetic parameters and biodistribution of soluble cytokine receptors, C.A. Jacobs, et al immunomodulation with soluble IFNG receptor - preliminary study, L. Ozmen, et al TNF receptors distribution in human tissues, B. Ryffel, et al. Part 3 Role of cytokines in disease: tumour necrosis factor/cachectin (TNF) as an effector of T-cell depedendent immunopathology, D.E. Grau, et al cytokines involved in pulmonary fibrosis, P.F. Piquet immune-mediated injury in bacterial meningitis, K. Frei, et al clinical experiences with alpha- and gamma- interferons, G.G. Steinmann, et al clinical experience with escherichia coli rhGM-CSF, A.C. Stern and T.C. Jones. International Review of Experimental Pathology, Volume 34: Cytokine-Induced Pathology Part B: Inflammatory Cytokines, Receptors, and Disease presents experimental findings obtained from the most recently studied cytokines and growth factors. The book is organized into three sections. Section I contains studies on pathology induced by inflammatory cytokines. Topics covered include the biological effects of interferon-?, tumor necrosis factor- a (TNF), interleukin-8, transforming growth factor-ß, and leukemia inhibitory factor on experimental animals; TNF-induced pathophysiologic alterations; and the biological activity of leukemia inhibitory factor (LIF). The papers in Section II examine cytokine receptors, including their structure and signal transduction; interferon-? (IFN-?) activity; and immunoregulatory role of TNF-a. Section III is devoted to cytokine receptors, including studies on TNF properties relevant to tissue injury and its role in T cell-mediated immunopathological reactions in vivo; the role of cytokines in experimental pulmonary fibrosis induced in mice; and the role of cytokines in bacterial meningitis. International Review of Experimental Pathology, Volume 34: Cytokine-Induced Pathology Part B: Inflammatory Cytokines, Receptors, and Disease presents experimental findings obtained from the most recently studied cytokines and growth factors. The book is organized into three sections. Section I contains studies on pathology induced by inflammatory cytokines. Topics covered include the biological effects of interferon-y, tumor necrosis factor- a (TNF), interleukin-8, transforming growth factor-ß, and leukemia inhibitory factor on experimental animals; TNF-induced pathophysiologic alterations; a .. One of a two-volume set which reviews the "in vivo" effects in experimental animals induced by several members of the cytokine family. Together, the volumes explain the pharmacological and toxicopathological effect of such haematopoietic growth factors as colony stimulating factors.