International Manual of Oncology Practice : IMOP - Principles of Oncology

Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2 nd edition of the International Manual of Oncology Practice (iMOP) emerged after the great success of the iMOP 1 st edition as a reference for medical oncologists and medical residents in the field. In this edition, several chapters were revised and its addresses from the molecular issues of cancer sciences to the clinical practice in medical oncology. In addition, multiple choice questions and clinical cases were included in the main chapters in order to improve the reader learning. The book focuses systemic treatments in many areas of medical oncology, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. The topics herein discussed will provide the readers a step forward in the medical oncology practice understanding and give facilities for help in cancer patient treatments. Front Matter ....Pages i-xv Front Matter ....Pages 1-1 Cancer Epidemiology and Screening (Gustavo Trautman Stock, Pedro Nazareth Aguiar Jr., Hakaru Tadokoro, Ramon Andrade De Mello)....Pages 3-15 Understanding Cancer Stem Cells Biology to Get Rid of Tumours (José Bragança, Gisela Machado-Oliveira, Ivette Pacheco-Leyva, Ana Catarina Matias)....Pages 17-32 Apoptosis (Richard Hill)....Pages 33-53 Tumour Angiogenesis (Patrícia Alexandra Madureira)....Pages 55-76 Genetic Basis of Metastasis (Catherine A. Moroski-Erkul, Esin Demir, Esra Gunduz, Mehmet Gunduz)....Pages 77-93 Anti-cancer Drugs – Discovery, Development and Therapy (Wolfgang Link)....Pages 95-111 Principles of Immuno-Oncology (Ana Mafalda Saraiva, Ramon Andrade De Mello, Pedro Madureira)....Pages 113-120 Health Economics (Nelson Teich, Vanessa Teich)....Pages 121-139 Front Matter ....Pages 141-141 Non-small Cell Lung Cancer (Apichat Tantraworasin, Sarawut Kongkarnka, Nirush Lertprasertsuke, Yutthaphan Wannasopha, Juntima Euathrongchit, Thatthan Suksombooncharoen et al.)....Pages 143-192 Small Cell Lung Cancer (Thatthan Suksombooncharoen, Apichat Tantraworasin, Sarawut Kongkarnka, Nirush Lertprasertsuke, Yutthaphan Wannasopha)....Pages 193-210 Mesothelioma (Vangelis Karamitrousis, Nikolaos Tsoukalas)....Pages 211-222 Epithelial Thymic Neoplasms (Mayndra Mychelle Landgraf, Daiane Pereira Guimarães, Hakaru Tadokoro, Ramon Andrade De Mello)....Pages 223-240 Breast Cancer (Inês Monteiro, Teresa Alvarez, Jean-Yves Meuwly, Khalil Zaman)....Pages 241-269 Esophageal Cancer (Karima Oualla, Nawfel Mellas, Luis Castelo-Branco, Ramon Andrade De Mello)....Pages 271-301 Gastric Cancer (Luis Castelo-Branco, Karima Oualla, Pedro Castelo-Branco, Ramon Andrade De Mello)....Pages 303-330 Colon Cancer (Pamela Carvalho Muniz, Hakaru Tadokoro, Ramon Andrade De Mello, Nora Manoukian Forones)....Pages 331-349 Rectal Cancer (Jinhui Zhu, Kai Yu, Ramon Andrade De Mello)....Pages 351-378 Anal Cancer (Tiago Costa de Pádua, Hakaru Tadokoro, Ramon Andrade De Mello, Nora Manoukian Forones)....Pages 379-389 Small Intestine Cancer (Pedro Nazareth Aguiar Jr., Carmelia Maria Noia Barreto, Nora Manoukian Forones, Hakaru Tadokoro, Ramon Andrade De Mello)....Pages 391-404 Liver Cancer (Thayse Gardini Alvarenga, Pamela Carvalho Muniz, Hakaru Tadokoro, Ramon Andrade De Mello, Nora Manoukian Forones)....Pages 405-420 Pancreatic Cancer (Georgios Antoniou, Ioannis Koutsounas, Panteleimon Kountourakis, Christos Pontas, Ramon Andrade De Mello)....Pages 421-470 Ovarian Cancer (Renata Félix da Justa, Ramon Andrade De Mello)....Pages 471-490 Approach and Management of Cervical Cancer (Alvaro Henrique Ingles Garces, Andreia Cristina de Melo, Eduardo Paulino, Angélica Nogueira-Rodrigues, Rachele Grazziotin, Márcio Lemberg Reisner et al.)....Pages 491-549 Vaginal Cancer (Michail Nikolaou)....Pages 551-564 Diagnosis and Management of Gestational Trophoblastic Neoplasia (Donald Peter Goldstein, Ross S. Berkowitz, Neil S. Horowitz)....Pages 565-581 Prostate Cancer (Helena Luna Pais, João Ulrich, Leonor Ribeiro)....Pages 583-623 Kidney Cancer: From Basics to Immunotherapy (Audrey Cabral Ferreira de Oliveira, Fernando Nunes Galvão de Oliveira)....Pages 625-657 Predictors of Oncologic Outcomes After Treatment of Urothelial Cancer (Kyle Spradling, Ramy F. Youssef)....Pages 659-673 Germ-Cell Tumors (Giannis Mountzios)....Pages 675-685 Penile Cancer (Nikolaos Tsoukalas, Konstantinos Tsapakidis, George Kyrgias, Maria Tolia)....Pages 687-696 Squamous Cell Carcinoma of the Head and Neck (Emmanuel Seront, Jean-Pascal Machiels, Sandra Schmitz)....Pages 697-720 Thyroid Cancer (Washington Luiz de Oliveira Gois Filho, Janssen Loiola Melo Vasconcelos, José William Ferreira Junior, Eric Fernandes Souza, Ricardo Lincoln Pinto Gondim, Erick Siqueira Campos de Oliveira et al.)....Pages 721-737 Parotid Gland Tumors (José Aurillo Rocha, Ramon Andrade De Mello)....Pages 739-752 Melanoma (Antonio Maria Grimaldi, Paolo Antonio Ascierto)....Pages 753-774 Soft Tissue Sarcomas (Carlos Márcio Melo de Matos, Irapuan Teles de Araújo Filho, Marcos Vieira Fernandes, Dárcio Jânio Macedo Barbosa, Afrânio Tavares André, Geourgius Antoniou et al.)....Pages 775-799 Bone Sarcomas (Gislaine Fernandes Silva, Daiane Pereira Guimarães, Hakaru Tadokoro, Ramon Andrade De Mello)....Pages 801-816 Gastrointestinal Stromal Tumor (GIST): Diagnosis and Treatment (Attila Kollár, Pedro Nazareth Aguiar Jr., Nora Manoukian Forones, Ramon Andrade De Mello)....Pages 817-849 Clinical Approaches to the Management of Neuroendocrine Tumours (K. L. Yim, B. M. Thomas, A. Christian)....Pages 851-867 Primary Brain Tumors in Adults (Fernando Silva Picon, Adrialdo José Santos, Hakaru Tadokoro, Ramon Andrade De Mello)....Pages 869-889 Front Matter ....Pages 891-891 Acute Lymphoblastic Leukemia (Eddy Supriyadi, Pudjo Hagung Widjajanto)....Pages 893-911 Myelodysplastic Syndromes (Ronald Feitosa Pinheiro, Priscila Timbó Azevedo, Carolina Teixeira Costa)....Pages 913-942 Front Matter ....Pages 943-943 Metabolic Disturbance (Pamela Carvalho Muniz, Mayndra Mychelle Landgraf, Fernando Silva Picon, Hakaru Tadokoro, Ramon Andrade De Mello, Michelle Samora de Almeida)....Pages 945-958 Neoplasic Epidural Spinal Cord Compression (Andrea Morais Borges, Adrialdo José Santos, Hakaru Tadokoro, Ramon Andrade De Mello)....Pages 959-972 Superior Vena Cava Syndrome (Maria Tolia, Nikolaos Tsoukalas, Ioannis Zerdes, Jiannis Hajiioannou, George Kyrgias)....Pages 973-989 Current Treatment of Febrile Neutropenia (Samantha Chao, Bora Lim)....Pages 991-1006 Chemotherapy Induced Nausea and Vomiting (Rudolph M. Navari)....Pages 1007-1045 Asthenia (F. Koinis, I. Gioulbasanis)....Pages 1047-1070 Clinical Approaches to Adult Cancer Pain (Daniel Humberto Pozza, Sara Gil-Mata, Andreia Fontoura Oliveira, Alice Turner, Ramon Andrade De Mello, Newton Barros)....Pages 1071-1113 Bone Metastasis (Arlindo R. Ferreira, André N. Abrunhosa-Branquinho, Marília Jorge, Luís Costa)....Pages 1115-1137 Brain Metastases (Tiago Costa de Pádua, Adrialdo José Santos, Hakaru Tadokoro, Ramon Andrade De Mello)....Pages 1139-1145 Chapter – Palliative Care (Caroline Souza dos Anjos, Débora Souza Gaudencio Feijó)....Pages 1147-1157 Back Matter ....Pages 1159-1162 "Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2nd edition of the International Manual of Oncology Practice (iMOP) emerged after the great success of the iMOP 1st edition as a reference for medical oncologists and medical residents in the field. In this edition, several chapters were revised and its addresses from the molecular issues of cancer sciences to the clinical practice in medical oncology. In addition, multiple choice questions and clinical cases were included in the main chapters in order to improve the reader learning. The book focuses systemic treatments in many areas of medical oncology, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. The topics herein discussed will provide the readers a step forward in the medical oncology practice understanding and give facilities for help in cancer patient treatments. ." - Prové de l'editor