Interleukin-10 in Health and Disease (Current Topics in Microbiology and Immunology Book 380)

"This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date."--Publisher's website Front Matter....Pages i-viii IL-10 in Humans: Lessons from the Gut, IL-10/IL-10 Receptor Deficiencies, and IL-10 Polymorphisms....Pages 1-18 Control of Intestinal Inflammation by Interleukin-10....Pages 19-38 Tr1 Cells and the Counter-Regulation of Immunity: Natural Mechanisms and Therapeutic Applications....Pages 39-68 Interleukin-10-Producing B Cells and the Regulation of Immunity....Pages 69-92 Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?....Pages 93-128 IL-10: Achieving Balance During Persistent Viral Infection....Pages 129-144 The Role of microRNAs in the Control and Mechanism of Action of IL-10....Pages 145-155 The Regulation of IL-10 Expression....Pages 157-190 The Molecular Basis of IL-10 Function: from Receptor Structure to the Onset of Signaling....Pages 191-212 Role of IL-22 in Microbial Host Defense....Pages 213-236 Back Matter....Pages 237-238 Simon Fillatreau, Anne O'garra, Editors. Includes Bibliographical References And Index.