Interactions of transmembrane peptides and proteins with lipid membranes studied by mass spectrometry

Jeroen Adrianus Antonius Demmers......Page 3 Prof. dr. J. A. Killian......Page 4 Aan mijn ouders......Page 5 Dw.pdf......Page 0 Dankwoord134......Page 7 General introduction......Page 9 Building blocks of membranes......Page 11 Integral membrane proteins......Page 13 Three-dimensional structures of integral membrane proteins in detail......Page 15 Structural characteristics of membrane-spanning (-helices......Page 16 Structural characteristics of membrane spanning domains in the membrane-water interfacial region......Page 18 In Chapter 4, I shall move from biophysical chemistry towards a physical chemistry related subject, which is about possible complications in H/D exchange studies that might result from gas-phase migration of deuterium atoms incorporated in the peptides......Page 30 In Chapter 6, the results presented in this thesis are summarized and discussed in the context of the present literature.......Page 31 Introduction......Page 43 Introduction......Page 59 Introduction......Page 79 Summarizing discussion......Page 109 Global hydrogen/deuterium exchange kinetics and mass spectrometry in studying peptide-membrane interactions......Page 111 General remarks on H/D exchange combined with nano-flow ESI-MS......Page 114 Dependence of exchange kinetics in membrane-associated peptides on the lipid environment......Page 119 Non-covalent interactions in a membrane environment......Page 120 Nederlandse samenvatting......Page 127 Curriculum vitae......Page 132 List of publications......Page 133 Dankwoord......Page 134