Integrins: Molecular and Biological Responses to the Extracellular Matrix (Biology of Extracellular Matrix)

Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer. Key Features* Describes key aspects of integrin structure, function. Read more... Content: Biology of Extracellular Matrix Series , Page ii , ROBERT P. MECHAM Front Matter , Page iii Copyright , Page iv Contributors , Pages ix-x Preface , Pages xi-xiv , David A. Cheresh, Robert P. Mecham The Structural Basis of Integrin—Ligand (RGD) Interaction , Pages 1-32 , Jeffrey W. Smith Integrins as Signal Transducing Receptors , Pages 33-47 , Martin A. Schwartz Interactions between Integrins and the Cytoskeleton: Structure and Regulation , Pages 49-78 , Keiko O. Simon, Keith Burridge Integrins, Signaling, and the Remodeling of the Extracellular Matrix , Pages 79-109 , John Ashkenas, Caroline H. Damsky, Mina J. Bissell, Zena Werb Integrins in Development , Pages 111-140 , Thomas Lallier, Mark D. Hens, Douglas W. DeSimone Distinctive Functions of α6β4 and Other Integrins in Epithelial Cells , Pages 141-161 , Vito Quaranta, Richard N. Tamura, Ginetta Collo, Helen M. Cooper, Marketta Hormia, Carla Rozzo, Guido Gaietta, Lisa Starr Leukocyte Integrins , Pages 163-194 , Mariano J. Elices Molecular Properties of Human Platelet Integrin α IIb β 3 , Pages 195-235 , Thomas J. Kunicki, Zaverio M. Ruggeri Therapeutic Potential of Integrin Antagonists , Pages 237-271 , Jeffrey M. Stadel, Andrew J. Nichols, Donald R. Bertolini, James M. Samanen Index , Pages 273-278 Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer.

Key Features
* Describes key aspects of integrin structure, function, and biology
* Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists
* Investigates the expression and role of integrins during development and in the cytoskeleton
* Includes the actions and influences of integrins in inflammation, thrombosis, and osteoporosis Intended for basic, applied, and clinical researchers, this volume addresses some areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer.